Detalhe da pesquisa
1.
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature
; 614(7948): 572-579, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36697823
2.
A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Nature
; 585(7826): 597-602, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612235
3.
Current methods to analyze lysosome morphology, positioning, motility and function.
Traffic
; 23(5): 238-269, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35343629
4.
TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex.
Nat Commun
; 15(1): 406, 2024 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38195686
5.
MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils.
J Biol Chem
; 287(53): 44603-18, 2012 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23115246
6.
Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency.
EMBO Mol Med
; 15(3): e14837, 2023 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36789546
7.
RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome.
Nat Commun
; 14(1): 2775, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37188688
8.
Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation.
Nat Commun
; 14(1): 3911, 2023 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37400440
9.
Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils.
J Biol Chem
; 286(7): 5647-56, 2011 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21148308
10.
Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation.
Nat Commun
; 13(1): 5529, 2022 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36130971
11.
Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin.
J Biol Chem
; 285(22): 16951-7, 2010 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20308062
12.
Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.
Infect Immun
; 79(9): 3607-18, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21746860
13.
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders.
Nat Commun
; 12(1): 3495, 2021 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34108486
14.
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype.
EMBO Mol Med
; 13(10): e13742, 2021 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34411438
15.
NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein.
J Cell Physiol
; 220(2): 410-7, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19365808
16.
mTOR-dependent phosphorylation controls TFEB nuclear export.
Nat Commun
; 9(1): 3312, 2018 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30120233
17.
Functional characterization of the TMLH gene: promoter analysis, in situ hybridization, identification and mapping of alternative splicing variants.
Gene
; 395(1-2): 86-97, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17408883
18.
MRX87 family with Aristaless X dup24bp mutation and implication for polyAlanine expansions.
BMC Med Genet
; 8: 25, 2007 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17480217
19.
mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy.
J Clin Invest
; 127(10): 3717-3729, 2017 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28872463
20.
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.
Science
; 356(6343): 1188-1192, 2017 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28619945