RESUMO
Vaccines offer an effective strategy to prevent infectious diseases with minimal adverse effects. On rare occasions, vaccination can disrupt the immune response leading to induction of autoimmune diseases. We describe a case of new-onset lupus nephritis following COVID-19 vaccination with the first dose of the Pfizer vaccine. Her symptoms and lab values improved with steroids, hydroxychloroquine, and mycophenolate mofetil.
Assuntos
COVID-19 , Lúpus Eritematoso Sistêmico , Nefrite Lúpica , Vacinas , Humanos , Feminino , Imunossupressores/uso terapêutico , Nefrite Lúpica/tratamento farmacológico , Vacinas contra COVID-19 , Quimioterapia Combinada , Lúpus Eritematoso Sistêmico/induzido quimicamente , Ácido Micofenólico/uso terapêuticoRESUMO
A dysregulated immune response plays a critical role in systemic lupus erythematosus (SLE) pathogenesis. Environmental factors such as viruses, including coronavirus 2 (COVID-19), have been described to play a role in SLE presentation and exacerbation. These viruses trigger a host's humoral and cellular immunities typically essential in elimination of the viral infection. We present a case of a Hispanic male who developed new-onset lupus nephritis class II after a COVID-19 infection.