Detalhe da pesquisa
1.
Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents.
Bioorg Med Chem Lett
; 72: 128858, 2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35718104
2.
Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators.
Bioorg Med Chem Lett
; 73: 128904, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35868496
3.
Personalized Metabolic Profile by Synergic Use of NMR and HRMS.
Molecules
; 26(14)2021 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34299442
4.
Comparison of different protein precipitation and solid-phase extraction protocols for the study of the catabolism of peptide drugs by LC-HRMS.
J Pept Sci
; 26(9): e3272, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32633064
5.
Application of an in Vitro Blood-Brain Barrier Model in the Selection of Experimental Drug Candidates for the Treatment of Huntington's Disease.
Mol Pharm
; 16(5): 2069-2082, 2019 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30916978
6.
An efficient liquid chromatography-high resolution mass spectrometry approach for the optimization of the metabolic stability of therapeutic peptides.
Anal Bioanal Chem
; 409(10): 2685-2696, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28138743
7.
Development of a neuromedin U-human serum albumin conjugate as a long-acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide.
J Pept Sci
; 20(1): 7-19, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24222478
8.
The Urine Metabolome of R6/2 and zQ175DN Huntington's Disease Mouse Models.
Metabolites
; 13(8)2023 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37623904
9.
Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species.
J Pharm Biomed Anal
; 227: 115256, 2023 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36764268
10.
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates.
J Med Chem
; 66(1): 641-656, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36548390
11.
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.
J Med Chem
; 66(18): 13205-13246, 2023 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37712656
12.
MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
Antimicrob Agents Chemother
; 56(8): 4161-7, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22615282
13.
Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase.
Bioorg Med Chem
; 20(15): 4801-11, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22770556
14.
PEGylation of Neuromedin U yields a promising candidate for the treatment of obesity and diabetes.
Bioorg Med Chem
; 20(15): 4751-9, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22771182
15.
Oligomerization, albumin binding and catabolism of therapeutic peptides in the subcutaneous compartment: An investigation on lipidated GLP-1 analogs.
J Pharm Biomed Anal
; 210: 114566, 2022 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35042144
16.
Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.
Sci Rep
; 12(1): 20435, 2022 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36443381
17.
N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.
Bioorg Med Chem Lett
; 21(18): 5283-8, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21802943
18.
Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2.
Bioorg Med Chem Lett
; 21(15): 4429-35, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21737263
19.
DPP-IV-resistant, long-acting oxyntomodulin derivatives.
J Pept Sci
; 17(4): 270-80, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21294225
20.
Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease.
Cell Rep Med
; 2(10): 100409, 2021 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34755129