Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.

Dosenovic, Pia; von Boehmer, Lotta; Escolano, Amelia; Jardine, Joseph; Freund, Natalia T; Gitlin, Alexander D; McGuire, Andrew T; Kulp, Daniel W; Oliveira, Thiago; Scharf, Louise; Pietzsch, John; Gray, Matthew D; Cupo, Albert; van Gils, Marit J; Yao, Kai-Hui; Liu, Cassie; Gazumyan, Anna; Seaman, Michael S; Björkman, Pamela J; Sanders, Rogier W; Moore, John P; Stamatatos, Leonidas; Schief, William R; Nussenzweig, Michel C.

Cell ; 161(7): 1505-15, 2015 Jun 18.

Artigo em Inglês | MEDLINE | ID: mdl-26091035

2.

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.

de Taeye, Steven W; Ozorowski, Gabriel; Torrents de la Peña, Alba; Guttman, Miklos; Julien, Jean-Philippe; van den Kerkhof, Tom L G M; Burger, Judith A; Pritchard, Laura K; Pugach, Pavel; Yasmeen, Anila; Crampton, Jordan; Hu, Joyce; Bontjer, Ilja; Torres, Jonathan L; Arendt, Heather; DeStefano, Joanne; Koff, Wayne C; Schuitemaker, Hanneke; Eggink, Dirk; Berkhout, Ben; Dean, Hansi; LaBranche, Celia; Crotty, Shane; Crispin, Max; Montefiori, David C; Klasse, P J; Lee, Kelly K; Moore, John P; Wilson, Ian A; Ward, Andrew B; Sanders, Rogier W.

Cell ; 163(7): 1702-15, 2015 Dec 17.

Artigo em Inglês | MEDLINE | ID: mdl-26687358

3.

Structural evolution of glycan recognition by a family of potent HIV antibodies.

Garces, Fernando; Sok, Devin; Kong, Leopold; McBride, Ryan; Kim, Helen J; Saye-Francisco, Karen F; Julien, Jean-Philippe; Hua, Yuanzi; Cupo, Albert; Moore, John P; Paulson, James C; Ward, Andrew B; Burton, Dennis R; Wilson, Ian A.

Cell ; 159(1): 69-79, 2014 Sep 25.

Artigo em Inglês | MEDLINE | ID: mdl-25259921

4.

Beta testing the monkey model.

Moore, John P; Gounder, Celine R.

Nat Immunol ; 22(10): 1201-1203, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34531563

5.

Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization.

Ringe, Rajesh P; Colin, Philippe; Ozorowski, Gabriel; Allen, Joel D; Yasmeen, Anila; Seabright, Gemma E; Lee, Jeong Hyun; Antanasijevic, Aleksandar; Rantalainen, Kimmo; Ketas, Thomas; Moore, John P; Ward, Andrew B; Crispin, Max; Klasse, P J.

PLoS Pathog ; 19(10): e1011601, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37903160

6.

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

Garces, Fernando; Lee, Jeong Hyun; de Val, Natalia; de la Pena, Alba Torrents; Kong, Leopold; Puchades, Cristina; Hua, Yuanzi; Stanfield, Robyn L; Burton, Dennis R; Moore, John P; Sanders, Rogier W; Ward, Andrew B; Wilson, Ian A.

Immunity ; 43(6): 1053-63, 2015 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-26682982

7.

Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization.

Colin, Philippe; Ringe, Rajesh P; Yasmeen, Anila; Ozorowski, Gabriel; Ketas, Thomas J; Lee, Wen-Hsin; Ward, Andrew B; Moore, John P; Klasse, P J.

Retrovirology ; 20(1): 9, 2023 05 27.

Artigo em Inglês | MEDLINE | ID: mdl-37244989

8.

Reappraising the Value of HIV-1 Vaccine Correlates of Protection Analyses.

Klasse, P J; Moore, John P.

J Virol ; 96(8): e0003422, 2022 04 27.

Artigo em Inglês | MEDLINE | ID: mdl-35384694

9.

The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization.

Schorcht, Anna; Cottrell, Christopher A; Pugach, Pavel; Ringe, Rajesh P; Han, Alvin X; Allen, Joel D; van den Kerkhof, Tom L G M; Seabright, Gemma E; Schermer, Edith E; Ketas, Thomas J; Burger, Judith A; van Schooten, Jelle; LaBranche, Celia C; Ozorowski, Gabriel; de Val, Natalia; Bader, Daniel L V; Schuitemaker, Hanneke; Russell, Colin A; Montefiori, David C; van Gils, Marit J; Crispin, Max; Klasse, P J; Ward, Andrew B; Moore, John P; Sanders, Rogier W.

J Virol ; 96(1): e0155221, 2022 01 12.

Artigo em Inglês | MEDLINE | ID: mdl-34669426

10.

Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates.

van Schooten, Jelle; van Haaren, Marlies M; Li, Hui; McCoy, Laura E; Havenar-Daughton, Colin; Cottrell, Christopher A; Burger, Judith A; van der Woude, Patricia; Helgers, Leanne C; Tomris, Ilhan; Labranche, Celia C; Montefiori, David C; Ward, Andrew B; Burton, Dennis R; Moore, John P; Sanders, Rogier W; Crotty, Shane; Shaw, George M; van Gils, Marit J.

PLoS Pathog ; 17(8): e1009736, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34432859

11.

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.

Blattner, Claudia; Lee, Jeong Hyun; Sliepen, Kwinten; Derking, Ronald; Falkowska, Emilia; de la Peña, Alba Torrents; Cupo, Albert; Julien, Jean-Philippe; van Gils, Marit; Lee, Peter S; Peng, Wenjie; Paulson, James C; Poignard, Pascal; Burton, Dennis R; Moore, John P; Sanders, Rogier W; Wilson, Ian A; Ward, Andrew B.

Immunity ; 40(5): 669-80, 2014 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-24768348

12.

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers.

Falkowska, Emilia; Le, Khoa M; Ramos, Alejandra; Doores, Katie J; Lee, Jeong Hyun; Blattner, Claudia; Ramirez, Alejandro; Derking, Ronald; van Gils, Marit J; Liang, Chi-Hui; Mcbride, Ryan; von Bredow, Benjamin; Shivatare, Sachin S; Wu, Chung-Yi; Chan-Hui, Po-Ying; Liu, Yan; Feizi, Ten; Zwick, Michael B; Koff, Wayne C; Seaman, Michael S; Swiderek, Kristine; Moore, John P; Evans, David; Paulson, James C; Wong, Chi-Huey; Ward, Andrew B; Wilson, Ian A; Sanders, Rogier W; Poignard, Pascal; Burton, Dennis R.

Immunity ; 40(5): 657-68, 2014 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-24768347

13.

Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike.

Ozorowski, Gabriel; Pallesen, Jesper; de Val, Natalia; Lyumkis, Dmitry; Cottrell, Christopher A; Torres, Jonathan L; Copps, Jeffrey; Stanfield, Robyn L; Cupo, Albert; Pugach, Pavel; Moore, John P; Wilson, Ian A; Ward, Andrew B.

Nature ; 547(7663): 360-363, 2017 07 20.

Artigo em Inglês | MEDLINE | ID: mdl-28700571

14.

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens.

Antanasijevic, Aleksandar; Ueda, George; Brouwer, Philip J M; Copps, Jeffrey; Huang, Deli; Allen, Joel D; Cottrell, Christopher A; Yasmeen, Anila; Sewall, Leigh M; Bontjer, Ilja; Ketas, Thomas J; Turner, Hannah L; Berndsen, Zachary T; Montefiori, David C; Klasse, Per Johan; Crispin, Max; Nemazee, David; Moore, John P; Sanders, Rogier W; King, Neil P; Baker, David; Ward, Andrew B.

PLoS Pathog ; 16(8): e1008665, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32780770

15.

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.

Cottrell, Christopher A; van Schooten, Jelle; Bowman, Charles A; Yuan, Meng; Oyen, David; Shin, Mia; Morpurgo, Robert; van der Woude, Patricia; van Breemen, Mariëlle; Torres, Jonathan L; Patel, Raj; Gross, Justin; Sewall, Leigh M; Copps, Jeffrey; Ozorowski, Gabriel; Nogal, Bartek; Sok, Devin; Rakasz, Eva G; Labranche, Celia; Vigdorovich, Vladimir; Christley, Scott; Carnathan, Diane G; Sather, D Noah; Montefiori, David; Silvestri, Guido; Burton, Dennis R; Moore, John P; Wilson, Ian A; Sanders, Rogier W; Ward, Andrew B; van Gils, Marit J.

PLoS Pathog ; 16(8): e1008753, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32866207

16.

Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.

Moore, John P R; Shehabi, Yahya; Reade, Michael C; Bailey, Michael; Fraser, John F; Murray, Lauren; Anstey, Christopher; Singer, Mervyn.

Crit Care ; 26(1): 359, 2022 11 22.

Artigo em Inglês | MEDLINE | ID: mdl-36419197

17.

Predictors of Nonseroconversion after SARS-CoV-2 Infection.

Liu, Weimin; Russell, Ronnie M; Bibollet-Ruche, Frederic; Skelly, Ashwin N; Sherrill-Mix, Scott; Freeman, Drew A; Stoltz, Regina; Lindemuth, Emily; Lee, Fang-Hua; Sterrett, Sarah; Bar, Katharine J; Erdmann, Nathaniel; Gouma, Sigrid; Hensley, Scott E; Ketas, Thomas; Cupo, Albert; Cruz Portillo, Victor M; Moore, John P; Bieniasz, Paul D; Hatziioannou, Theodora; Massey, Greer; Minyard, Mary-Beth; Saag, Michael S; Davis, Randall S; Shaw, George M; Britt, William J; Leal, Sixto M; Goepfert, Paul; Hahn, Beatrice H.

Emerg Infect Dis ; 27(9): 2454-2458, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34193339

18.

COVID-19 Vaccines: "Warp Speed" Needs Mind Melds, Not Warped Minds.

Moore, John P; Klasse, P J.

J Virol ; 94(17)2020 08 17.

Artigo em Inglês | MEDLINE | ID: mdl-32591466

19.

Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin.

Ringe, Rajesh P; Cruz Portillo, Victor M; Dosenovic, Pia; Ketas, Thomas J; Ozorowski, Gabriel; Nogal, Bartek; Perez, Lautaro; LaBranche, Celia C; Lim, Jillian; Francomano, Erik; Wilson, Ian A; Sanders, Rogier W; Ward, Andrew B; Montefiori, David C; Nussenzweig, Michel C; Klasse, P J; Cupo, Albert; Moore, John P.

J Virol ; 94(6)2020 02 28.

Artigo em Inglês | MEDLINE | ID: mdl-31852794

20.

Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers.

Schorcht, Anna; van den Kerkhof, Tom L G M; Cottrell, Christopher A; Allen, Joel D; Torres, Jonathan L; Behrens, Anna-Janina; Schermer, Edith E; Burger, Judith A; de Taeye, Steven W; Torrents de la Peña, Alba; Bontjer, Ilja; Gumbs, Stephanie; Ozorowski, Gabriel; LaBranche, Celia C; de Val, Natalia; Yasmeen, Anila; Klasse, Per Johan; Montefiori, David C; Moore, John P; Schuitemaker, Hanneke; Crispin, Max; van Gils, Marit J; Ward, Andrew B; Sanders, Rogier W.

J Virol ; 94(24)2020 11 23.

Artigo em Inglês | MEDLINE | ID: mdl-32999024

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