Concentraciones de Vitamina D en niños y adolescentes con enfermedad celíaca / Vitamin D concentrations in children and adolescents with celiac disease

INTRODUCCIÓN: En celíacos la ingesta de gluten provoca una lesión inflamatoria de origen autoinmune que causa un daño progresivo de las vellosidades del intestino delgado, comprometiendo la absorción de nutrientes y posible daño a otros órganos. OBJETIVO: Determinar las concentraciones plasmáticas de 25-hidroxivitamina D (25OHD) en niños y adolescentes chilenos con enfermedad celíaca. PACIENTES Y MÉTODO: Estudio descriptivo de corte transversal. Participaron 16 pacientes pediátricos de ambos sexos, diagnosticados con enfermedad celíaca. Se determinó antecedentes ge nerales, estado nutricional y parámetros bioquímicos. Las concentraciones plasmáticas de 25OHD se clasificaron como suficientes cuando estaban entre 30-100 ng/ml, insuficiente (20-29 ng/ml) y deficiente (< 20 ng/ml). RESULTADOS: La edad de los pacientes estaba comprendida entre 5 y 18 edad (edad: 11 ± 4 años). De los participantes 4 de 16 presentaron concentraciones normales de 25OHD, 8 insuficiente y 1 deficiente. Según IMC, 11 tenían estado nutricional normal, 4 sobrepeso y 1 obesidad. El diagnóstico de la talla mostró 7 de 16 casos de talla baja y normal baja. Al relacionar las concentraciones de 25OHD con estado nutricional, los parámetros deficientes e insuficientes se concentraron en 9 pacientes con estado nutricional normal, 2 con sobrepeso y 1 con obesidad. Se realizaron asociaciones entre las concentraciones de 25OHD y todas las variables estudiadas y no se encontró ninguna asociación significativa. CONCLUSIÓN: Se encontró una alta frecuencia de insuficiencia y deficiencia de 25OHD en el grupo de niños y adolescentes chilenos con enfermedad celíaca.

INTRODUCTION: In children with celiac disease, gluten intake causes an autoimmune, inflammatory and progressive lesion of the small intestine villi, compromising the absorption of nutrients and pos sible damage to others organs. OBJECTIVE: To determine plasma 25-hydroxyvitamin D [25(OH)D] concentrations in Chilean child and adolescents with celiac disease. PATIENTS AND METHOD: A descriptive cross-sectional study was carried out in which 16 pediatric patients of both genders diagnosed with celiac disease participated. General background, nutritional status and biochemical parameters were determined. Plasma 25(OH)D concentrations were classified as sufficient between 30-100 ng/ ml, insufficient between 20-30 ng/ml and deficient as <20 ng/ml. RESULTS: The age of the patients was between 5 and 18 years (age: 11 ± 4 years). Four out of 16 participants had normal 25(OH)D concentrations, eight had insufficient concentrations and one had deficient concentrations. Accor ding to BMI, 11 patients had normal nutritional status, four were overweight and one was obese. In relation to height, seven out of 16 cases presented short stature and normal-low height. Associating 25(OH)D concentrations to nutritional status, nine patients with normal nutritional status, two with overweight and one with obesity presented deficient and insufficient parameters. No significant asso ciations were found between 25(OH)D concentrations and all studied variables. CONCLUSION: A high frequency of insufficiency and deficiency of 25(OH)D was found in the group of Chilean children and adolescents with celiac disease.

Riesgo de trastorno de la conducta alimentaria en adolescentes chilenos de diferentes tipos de establecimientos educacionales / Risk of eating disorders in Chilean adolescents of different types educational establishments

Los trastornos de la conducta alimentaria (TCA) son patologías de salud mental complejas, caracterizados por una alteración persistente del comer o del comportamiento relacionado con la alimentación. El objetivo de este estudio fue determinar el riesgo de TCA en adolescentes de diferentes tipos de establecimientos educacionales de la ciudad de Concepción, Chile. La muestra fue constituida por estudiantes de 7mo año básico a 4to año de enseñanza media, cuyo rango de edad fue de 13 a 18 años, pertenecientes a establecimientos educacionales municipalizados, particular subvencionados y particular, de la ciudad de Concepción. Para determinar riesgo de TCA, se empleó el instrumento de Test de Actitudes Alimentarias (EAT-40), junto a ello se realizaron mediciones de peso y talla para calcular el Índice de Masa Corporal. La muestra final comprendió 1056 estudiantes, de los cuales 37,5% eran hombres y 62,5% eran mujeres. El riesgo de desarrollar un TAC fue de 16,1%, siendo mayor en mujeres (21,8%) en relación con los hombres (6,6%) (p<0.001). Se evidenció mayor riesgo de TCA en mujeres con estado nutricional con sobrepeso (27,7%) y en hombres con estado nutricional de obesidad (14,7%). Al evaluar riesgo de TCA por tipo de establecimientos educacionales, se observan diferencias, pero sin resultados significativos (p 0,2008). Es relevante contar con políticas públicas que permitan abordar y acompañar a los adolescentes en riesgo de desarrollar un TCA(AU)

Eating disorders are complex mental health illnesses, characterized by irregular eating habits or behavior related to food. The purpose of this study was to determine the risk of eating disorders in adolescents from different educational establishments in the city of Concepción. The sample was constituted by students of seventh grade of basic education to fourth year of secondary, whose age range was from 13 to 18, belonging to public, subsidized and private educational establishments in the city of Concepción. To determine the risk of eating disorder, the Eating Attitudes (EAT-40) was used, and weight and height were measured to calculate body mass index. The final sample was composed of 1056 students, of which 37,5% were men and 62,5% women. The risk of developing an eating disorder was 16,1%, being higher in women (21,8%) in relation to men (6,6%) (p <0,001). It was demonstrated a higher risk of TCA in overweight women (27, 7%) and men with obesity (14, 7%). In assessing risks of TCA per type of educational establishments there were some differences but without significant results (p 0, 2008). It is essential to have public policies that allow the approach and accompany adolescents at risk of developing a disorder of eating behavior(AU)

Evaluación nutricional y adherencia a la dieta mediterránea de adolescentes chilenos que residen en hogares de familias hospedadoras / Nutritional assessment and adherence to the mediterranean diet of chilean adolescents residing in host families

El estilo de vida de los adolescentes puede conducir a hábitos y preferencias alimentarias poco saludables que promueven al sobrepeso y la obesidad, siendo un factor de riesgo presente y futuro para el desarrollo de enfermedades crónicas. La dieta mediterránea es uno de los modelos más saludables de alimentación por su asociación a una mayor esperanza de vida y a su efecto protector de las enfermedades crónicas. El objetivo de este estudio fue determinar el estado nutricional y la adherencia a una dieta mediterránea de un grupo de adolescentes chilenos que residen en hogares de familias hospedadoras. El diseño del estudio fue descriptivo y de corte transversal. Participaron 40 adolescentes de ambos sexos y de edad entre 14 y 22 años, que por motivos de estudio se trasladan a la ciudad para vivir en hogares de familias hospedadoras. Para la evaluación del estado nutricional se realizaron mediciones antropométricas y se aplicó el test KIDMED para evaluar el grado de adherencia a la dieta mediterránea. Los resultados indicaron que 50% de los adolescentes estudiados presentaban malnutrición por exceso y una baja adherencia a la dieta mediterránea. Se concluye que la mayoría de los adolescentes estudiados presentan malnutrición por exceso; y su alimentación se aleja de las recomendaciones de una alimentación saludable y protectora como lo es la dieta mediterránea.

The lifestyle of adolescents can lead to eating habits and preferences least healthy that can cause overweight and obesity, making this a present and future risk factor for the develop-ment of chronic diseases. The Mediterranean diet is one of the healthiest eating models for its association to a greater hope of life and protection of chronic diseases. The objective of this study was to determine the nutritional status and adherence to the Mediterranean diet of a group of Chilean adolescents that reside in homes of housing families. The design of the study was descriptive crossectional. Participants were 40 adolescents of both sexes between 14 and 22 years of age, who for study moved to the city to live in homes of host families. For the evaluation of the nutritional status, anthropometric measurements were made and the KIDMED test was applied to evaluate the grade of adherence to the mediterranean diet. The results indicate that 50% of the adolescents in the study present ed malnutrition due to excess and low adherence to the Mediterranean diet. In conclusion most adolescents present malnutrition for excess; and their feeding stride far from the recommendations of a healthy and protective diet as the Mediterranean diet.

Sources of contamination and modelled pollutant trajectories in a Mediterranean harbour (Tarragona, Spain).

The proximity of commercial harbours to residential areas and the growing environmental awareness of society have led most port authorities to include environmental management within their administration plan. Regarding water quality, it is necessary to have the capacity and tools to deal with contamination episodes that may damage marine ecosystems and human health, but also affect the normal functioning of harbours. This paper presents a description of the main pollutant sources in Tarragona Harbour (Spain), and a numerical analysis of several pollution episodes based on the Port Authority's actual environmental concerns. The results show that pollution generated inside the harbour tends to remain confined within the port, whereas it is very likely that oil spills from a nearby monobuoy may affect the neighbouring beaches. The present combination of numerical models proves itself a useful tool to assess the environmental risk associated to harbour activities and potential pollution spills.

Enfermedad granulomatosa crónica en paciente pediátrico y trasplante de médula ósea como tratamiento curativo / Chronic granulomatous disease in pediatric patients and bone marrow transplantation as a curative treatment

INTRODUCCIÓN: La enfermedad granulomatosa crónica (EGC) es una inmunodeficiencia primaria, caracterizada por la incapacidad de células fagocíticas para producir sustancias necesarias para destruir microorganismos. Actualmente, el trasplante de médula ósea como tratamiento curativo de la EGC ha demostrado ser una prometedora alternativa terapéutica. PRESENTACIÓN DEL CASO: Lactante menor de 8 meses, ingresa a Unidad de Cuidados Especiales Pediátricos por cuadro de nueve días de evolución caracterizado por fiebre de 39ºC, calofríos, meteorismo y distensión abdominal, sin foco clínico evidente. EXÁMENES: hemograma con leucocitosis y desviación izquierda, PCR 103 mg/L, urocultivo positivo para bacilos gram negativos e inmunoglobulinas en rango bajo. Cintigrama óseo normal. Ecografía abdominal; hepatomegalia, linfonodos mesentéricos reactivos y líquido ascítico. Gram ganglionar mesentérico; Cándida lusitaniae positiva y dudoso Mycobacterium tuberculosis. Se efectúa estudio con estallido respiratorio, evidenciándose alteración severa compatible con diagnóstico de EGC. Se inicia tratamiento antifúngico, antituberculoso y administración de gammaglobulina endovenosa. Considerando diagnóstico se agrega interferón gamma 50 ug/m2 tres veces por semana. Al controlarse la infección, se realiza Trasplante Alogénico de Precursores Hematopoyéticos (TPH) con sangre de cordón umbilical de donante no emparentado, evidenciándose tres meses posterior al procedimiento remisión de la EGC por un estallido respiratorio normal. Actualmente estable con manejo ambulatorio, cursando anemia hemolítica autoinmune como complicación leve y tardía del TPH. DISCUSIÓN: El diagnóstico precoz e inicio adecuado del tratamiento antimicrobiano e interferón gamma ha modificado favorablemente la morbimortalidad de pacientes con EGC. No obstante, el tratamiento curativo con TPH es una alternativa terapéutica eficaz y prometedora en estos pacientes

INTRODUCTION: Chronic granulomatous disease (CGD) is a primary immunodeficiency, characterized by the inability of phagocytic cells to produce substances needed to destroy certain microorganisms. In recent years, marrow transplantation has been effective for patients with CGD. CASE REPORT: Breastfed infant of eight months was admitted to the Pediatric Special Care Unit for nine days, exhibiting the following symptoms despite no clinical source of infection: a 39°C fever, chills, bloating, and abdominal distension. EXAMS: hemogram showed leukocytosis with left shift, PCR 103 mg/L, positive urine culture for gram-negative bacilli, immunoglobulin in low range. Normal bone scintigraphy. Abdominal ultrasound; hepatomely, reactive mesenteric lymph nodes and ascites fluid. Mesenteric lymph nodes gram: positive for Candida lusitaniae and inconclusive evidence for Mycobacterium tuberculosis. Later, a respiratory burst revealed the absence of an immune response, consistent with a diagnosis of CGD. Antifungal, anti-tuberculosis, and intravenous gamma globulin were administered, as well as 50ug/m2 of interferon gamma delivered three times per week. Once the infection had been controlled, the patient received an Allogeneic Hematopoietic Stem Cell Transplant (HSCT) with cord blood from an unrelated donor. Over the following three months, respiratory burst was normal, evidencing CGD's remission. The patient is currently stable with ambulatory management and a mild case of autoimmune hemolytic anemia, a common delayed-onset complication of an Allogenic HSCT. DISCUSSION: Early diagnosis and appropriate initiation of antimicrobial and interferon gamma treatment favorably impacts the morbidity and mortality of CGD patients. However, an Allogenic HSCT has proven to be an even more effective curative treatment

Mobilization and collection of peripheral blood stem cells: guidelines for blood volume to process, based on CD34-positive blood cell count in adults and children.

We report 189 mobilizations and 489 collections of peripheral blood stem cells (PBSC) performed in 139 autologous transplantation patients and in 28 donors for allogeneic transplantations whose ages ranged from 2-68 years. We observed a correlation (P < .001; Pearson's coefficient 0.64) between CD34-positive cells and granulocyte-macrophage colony-forming units examined to estimate PBSC. In a subset of 287 collections (97 adults and 49 children) we obtained peripheral blood (PB) CD34-positive cell counts at 2 to 4 hours before leukapheresis. We noted a correlation between PB CD34-positive cell counts before leukapheresis and the number of CD34-positive cells per kilogram of body weight collected in the whole apheresis of the day (P < .001; Pearson's coefficient 0.82). An even better correlation was obtained between PB CD34-positive cells preapheresis and the yield of each individual blood volume (BV) processed (P < .001; Pearson's coefficient 0.87). Healthy donors and patients in each age group behaved similarly. In addition, the collection yield was greater among children than adults. These findings allowed us to develop a simple predictive model to estimate the BV to process for a target dose of CD34-positive cells per kilogram, based on the level of PBSC before apheresis in children and adults.

Evaluación de una intervención en actividad física en niños con síndrome de Down / Evaluation of a physical activity intervention among children with Down's syndrome

Introduction: In Chile there are no studies regarding the effects of physical activity on nutritional status of children with Down Syndrome. Objective: To evaluate the impact of a 12 week physical education program on the nutritional status, aerobic capacity and muscle strength in children with Down Syndrome. Subjects and Methods: Between August and November of 2006, a group of 18 children (10 males and 8 females) with Down Syndrome, aged between 5-9 years, underwent to a physical activity program over a 12 week period. A diagnostic and final evaluation of muscle strength variables (dorsal, abdominal and quadriceps) and aerobic capacity was done. Nutritional status was assessed by P/E and T/E (Fundación Catalana), IMC, IP/T and percentage of body fat. Results: Significant differences in muscle strength, aerobic capacity, IP/T and waist circumference were observed between the pre-test and post-test (p < 0.05). At the beginning of the intervention, 53 percent were overweight according to IMC, 26 percent to P/E and 68 percent according to IP/T; with an average percentage of body fat of 22.6 percent. Conclusion: Although the period of intervention was brief, a significant improvement was noted in muscle strength, aerobic capacity, IP/T and waist circumference. According to our results, there is a high prevalence of overweight status and obesity in this population of children with DS in which intervention with adequate physical activity is vital.

Introducción: En Chile no existen estudios acerca del efecto de la actividad física sobre el estado nutricional en niños con síndrome de Down. Objetivo: Conocer el estado nutricional en niños con síndrome de Down y la capacidad aeróbica y resistencia al esfuerzo muscular antes y después de una intervención en actividad física. Material y Método: Entre agosto y noviembre del año 2006, en un grupo de 18 niños (10 hombres y 8 mujeres) con síndrome de Down, con edades comprendidas entre 5 - 9 años, se desarrolló un estudio de intervención en actividad física de 12 semanas, realizándose una evaluación diagnóstica y una evaluación final de resistencia muscular (dorsal, abdominal y cuadriceps) y capacidad aeróbica. Se evaluó el estado nutricional a través de P/E y T/E (Fundación Catalana), IMC, IP/T y porcentaje de masa grasa. Resultados: Se observaron diferencias significativas en resistencia muscular, capacidad aeróbica, IP/T y circunferencia de cintura entre el pre-test y post-test (p < 0,05). AlI inicio de la intervención un 53 por ciento presentaba exceso de peso según IMC, un 26 por ciento según P/E y un 68 por ciento según IP/T; con un porcentaje masa grasa fue de 22,6 por ciento. Conclusión: Aunque el tiempo de intervención fue breve, se observó una mejora significativa en la resistencia muscular, capacidad aeróbica, IP/T y circunferencia de cintura. De acuerdo a nuestros resultados, existe una alta prevalencia de malnutrición por exceso en esta población de niños con SD en la que se hace vital intervenir con una actividad física adecuada.

[Spreading of Listeria monocytogenes in cheese dairy products]. / Indagine sulla diffusione di Listeria monocytogenes in prodotti lattiero caseari.

The increasingly more frequent occurrences of epidemic nidus of Listeria monocytogenes induced the E.E.C. Health Organisation to research into the diffusion of such microorganism. During the first six months of 1988 the "Istituto Superiore di Sanità" began a research into the presence of Listeria monocytogenes in milk and dairy products. The biological section of the "Laboratorio di Sanità Pubblica" of Grugliasco (Torino) participated in this study and in this work methods and results are reported. Changing the F.D.A. methods, incubation time was reduced. The percentage of positive samples was 4.6%, especially in dairy products with cheese mould. These results confirm an environmental diffusion of Listeria monocytogenes, nevertheless non illness caused by Listeria monocytogenes was recorded in the population who ate these products. Therefore the problem of Listeria monocytogenes pathogenicity and its diffusion by food remains to be clarified.