Application of Oxygen-Group-Based Amorphous Nanomaterials in Electrocatalytic Water Splitting.

Environmentally friendly energy sources (e.g., hydrogen) require an urgent development targeting to address the problem of energy scarcity. Electrocatalytic water splitting is being explored as a convenient catalytic reaction in this context, and promising amorphous nanomaterials (ANMs) are receiving increasing attention due to their excellent catalytic properties.Oxygen group-based amorphous nanomaterials (O-ANMs) are an important component of the broad family of ANMs due to their unique amorphous structure, large number of defects, and abundant randomly oriented bonds, O-ANMs induce the generation of a larger number of active sites, which favors a better catalytic activity. Meanwhile, amorphous materials can disrupt the inherent features of conventional crystalline materials regarding electron transfer paths, resulting in higher flexibility. O-ANMs mainly include VIA elements such as oxygen, sulfur, selenium, tellurium, and other transition metals, most of which are reported to be free of noble metals and have comparable performance to commercial catalysts Pt/C or IrO2 and RuO2 in electrocatalysis. This review covers the features and reaction mechanism of O-ANMs, the synthesis strategies to prepare O-ANMs, as well as the application of O-ANMs in electrocatalytic water splitting. Last, the challenges and prospective remarks for future development in O-ANMs for electrocatalytic water splitting are concluded.

Simple Bottom-Up Synthesis of Bismuthene Nanostructures with a Suitable Morphology for Competitive Performance in the Electrocatalytic Nitrogen Reduction Reaction.

Nitrogen reduction to ammonia under ambient conditions has received important attention, in which high-performing catalysts are sought. A new, facile, and seedless solvothermal method based on a high-temperature reduction route has been developed in this work for the production of bismuthene nanostructures with excellent performance in the electrocatalytic nitrogen reduction reaction (NRR). Different reaction conditions were tested, such as the type of solvent, surfactant, reducing agent, reaction temperature, and time, as well as bismuth precursor source, resulting in distinct particle morphologies. Two-dimensional sheet-like structures and small particles displayed very high electrocatalytic activity, attributed to the abundance of tips, edges, and high surface area. NRR experiments resulted in an ammonia yield of 571 ± 0.1 µg h-1 cm-2 with a respective Faradaic efficiency of 7.94 ± 0.2% vs Ag/AgCl. The easy implementation of the synthetic reaction to produce Bi nanostructures facilitates its potential scale up to larger production yields.

Magnetic Nanocomposites of Coated Ferrites/MOF as Pesticide Adsorbents.

Magnetic metal-organic frameworks (MMOFs) are gaining increased attention as emerging adsorbents/water remediation agents. Herein, a facile development of novel MMOFs comprised of coated ferrite nanoparticles (MNPs) and UiO-66 metal-organic framework is reported. In specific, coated Co- and Zn-doped ferrite magnetic nanoparticles were synthesized as building block while the metal-organic framework was grown in the presence of MNPs via a semi-self-assembly approach. The utilization of coated MNPs facilitated the conjugation and stands as a novel strategy for fabricating MMOFs with increased stability and an explicit structure. MMOFs were isolated with 13-25 nm crystallites sizes, 244-332 m2/g specific surface area (SSA) and 22-42 emu/g saturation magnetization values. Establishing the UiO-66 framework via the reported semi-self-assembly resulted in roughly 70% reduction in both magnetic properties and SSA, compared with the initial MNPs building blocks and UiO-66 framework, respectively. Nonetheless, the remaining 30% of the magnetization and SSA was adequate for successful and sufficient adsorption of two different pesticides, 2,4-Dichlorophenoxyacetic acid (2,4-D) and 2,4,5-Trichlorophenoxyacetic acid (2,4,5-T), while the recovery with a commercial magnet and reuse were also found to be effective. Adsorption and kinetic studies for all three MMOFs and both pesticides were performed, and data were fitted to Langmuir-Freundlich isotherm models.

Development and Characterization of Curcumin-Silver Nanoparticles as a Promising Formulation to Test on Human Pterygium-Derived Keratinocytes.

Pterygium is a progressive disease of the human eye arising from sub-conjunctival tissue and extending onto the cornea. Due to its invasive growth, pterygium can reach the pupil compromising visual function. Currently available medical treatments have limited success in suppressing efficiently the disease. Previous studies have demonstrated that curcumin, polyphenol isolated from the rhizome of Curcuma longa, induces apoptosis of human pterygium fibroblasts in a dose- and time-dependent manner showing promising activity in the treatment of this ophthalmic disease. However, this molecule is not very soluble in water in either neutral or acidic pH and is only slightly more soluble in alkaline conditions, while its dissolving in organic solvents drastically reduces its potential use for biomedical applications. A nanoformulation of curcumin stabilized silver nanoparticles (Cur-AgNPs) seems an effective strategy to increase the bioavailability of curcumin without inducing toxic effects. In fact, silver nitrates have been used safely for the treatment of many ophthalmic conditions and diseases for a long time and the concentration of AgNPs in this formulation is quite low. The synthesis of this new compound was achieved through a modified Bettini's method adapted to improve the quality of the product intended for human use. Indeed, the pH of the reaction was changed to 9, the temperature of the reaction was increased from 90 °C to 100 °C and after the synthesis the Cur-AgNPs were dispersed in Borax buffer using a dialysis step to improve the biocompatibility of the formulation. This new compound will be able to deliver both components (curcumin and silver) at the same time to the affected tissue, representing an alternative and a more sophisticated strategy for the treatment of human pterygium. Further in vitro and in vivo assays will be required to validate this formulation.

Plasmonic Metallic Heteromeric Nanostructures.

Binary, ternary, and other high-order plasmonic heteromers possess remarkable physical and chemical properties, enabling them to be used in numerous applications. The seed-mediated approach is one of the most promising and versatile routes to produce plasmonic heteromers. Selective growth of one or multiple domains on desired sites of noble metal, semiconductor, or magnetic seeds would form desired heteromeric nanostructures with multiple functionalities and synergistic effects. In this work, the challenges for the synthetic approaches are discussed with respect to tuning the thermodynamics, as well as the kinetic properties (e.g., pH, temperature, injection rate, among others). Then, plasmonic heteromers with their structure advantages displaying unique activities compared to other hybrid nanostructures (e.g., core-shell, alloy) are highlighted. Some of the main most recent applications of plasmonic heteromers are also presented. Finally, perspectives for further exploitation of plasmonic heteromers are demonstrated. The goal of this work is to provide the current know-how on the synthesis routes of plasmonic heteromers in a summarized manner, so as to achieve a better understanding of the resulting properties and to gain an improved control of their performances and extend their breadth of applications.

Magnetic nanoemulsions as candidates for Alzheimer's disease dual imaging theranostics.

Alzheimer's disease (AD) is the most prevalent cause of dementia linked to the accumulation of amyloid-beta (Aß) plaques-fibrils that impair cognitive functions. Magnetic nanoparticles (MNPs) are emerging as promising tools for the crusade against AD owning to appropriate biocompatibility and facile functionalization that can lead to theranostic agents. Herein, the fabrication of a multimodal (magnetic resonance imaging (MRI), fluorescence imaging, and drug carrier) magnetic nanoemulsion (MNE) is reported as an AD theranostic candidate. Initially zinc ferrite MNPs of high saturation magnetization (129 emu g-1) were synthesized through a modified microwave-assisted polyol process. Memantine (a registered AD drug) was labeled with fluorescein (Mem-Flu) and encapsulated with the MNPs in sodium dodecyl sulfate micelles to form the MNE. Small hydrodynamic size (107), high encapsulation (77.5%) and loading efficiencies (86.1%) and sufficient transverse relaxivity (48.7 mM-1 s-1) were achieved through the design while sustained release of Mem-Flu was unveiled by in zero-order, first-order, Higuchi and Korsmeyer-Peppas pharmacokinetic models. Moreover, the MNE acquired fluorescence imaging ability of Aß1-42 peptide monomers and/or plaques-fibrils via the fluorescein labeling of Memantine. A novel inorganic-organic hybrid multimodal AD theranostic candidate is presented.

Air-Stable Anisotropic Monocrystalline Nickel Nanowires Characterized Using Electron Holography.

Nickel is capable of discharging electric and magnetic shocks in aerospace materials thanks to its conductivity and magnetism. Nickel nanowires are especially desirable for such an application as electronic percolation can be achieved without significantly increasing the weight of the composite material. In this work, single-crystal nickel nanowires possessing a homogeneous magnetic field are produced via a metal-organic precursor decomposition synthesis in solution. The nickel wires are 20 nm in width and 1-2 µm in length. The high anisotropy is attained through a combination of preferential crystal growth in the ⟨100⟩ direction and surfactant templating using hexadecylamine and stearic acid. The organic template ligands protect the nickel from oxidation, even after months of exposure to ambient conditions. These materials were studied using electron holography to characterize their magnetic properties. These thin nanowires display homogeneous ferromagnetism with a magnetic saturation (517 ± 80 emu cm-3), which is nearly equivalent to that of bulk nickel (557 emu cm-3). Nickel nanowires were incorporated into carbon composite test pieces and were shown to dramatically improve the electric discharge properties of the composite material.

Hydrophilic Pt nanoflowers: synthesis, crystallographic analysis and catalytic performance.

Water-soluble Pt nanoflowers (NFs) were prepared by diethylene glycol-mediated reduction of Pt acetylacetonate (Pt(acac)2) in the presence of polyethylenimine. Advanced electron microscopy analysis showed that the NFs consist of multiple branches with a truncated cubic morphology and different crystallographic orientations. We demonstrate that the nature of the solvent strongly influences the resulting morphology. The catalytic performance of the Pt NFs in 4-nitrophenol reduction was found to be superior to that of other nanoparticle-based catalysts. Additionally, the Pt NFs display good catalytic reusability with no loss of activity after five consecutive cycles.

Colloidal Chiral Carbon Dots: An Emerging System for Chiroptical Applications.

Chiral CDots (c-CDots) not only inherit those merits from CDots but also exhibit chiral effects in optical, electric, and bio-properties. Therefore, c-CDots have received significant interest from a wide range of research communities including chemistry, physics, biology, and device engineers. They have already made decent progress in terms of synthesis, together with the exploration of their optical properties and applications. In this review, the chiroptical properties and chirality origin in extinction circular dichroism (ECD) and circularly polarized luminescence (CPL) of c-CDots is briefly discussed. Then, the synthetic strategies of c-CDots is summarized, including one-pot synthesis, post-functionalization of CDots with chiral ligands, and assembly of CDots into chiral architectures with soft chiral templates. Afterward, the chiral effects on the applications of c-CDots are elaborated. Research domains such as drug delivery, bio- or chemical sensing, regulation of enzyme-like catalysis, and others are covered. Finally, the perspective on the challenges associated with the synthetic strategies, understanding the origin of chirality, and potential applications is provided. This review not only discusses the latest developments of c-CDots but also helps toward a better understanding of the structure-property relationship along with their respective applications.

Disentangling the "tip-effects" enhanced antibacterial mechanism of Ag nanoparticles.

Silver nanoparticles (Ag NPs) exhibit strong antibacterial activity and are widely used in industries such as medical, food and cosmetics. In this study, Ag nanospheres and Ag nanotriangles are selected as antibacterial agents to reveal the distinct mechanism of tip effects towards their antibacterial performance. A series of antibacterial experiments were implemented, including in situ monitoring as well as studying and determining the evolution of the inhibition zone, minimum inhibitory concentration (MIC)/minimum bactericidal concentration (MBC) values, growth kinetics, bactericidal curve, bacterial morphologies and intracellular reactive oxygen species (ROS). Ag nanotriangles can eradicate E. coli and S. aureus at extremely low concentrations in comparison to Ag nanospheres, in particular under sunlight irradiation. The destroyed bacterial cell walls were examined by scanning electron microscopy. Through the investigation of ROS production, the generation efficiency of ROS is improved by the merit of sunlight irradiation thanks to the localized surface plasmon resonance (LSPR) properties of Ag NPs. However, a more significant improvement in ROS generation efficiency occurred in the presence of Ag nanotriangles contributed by the pronounced "tip effects". This study sheds light on the structure-performance relationship for the rational design of antibacterial agents.

Reaction Mechanism and Performance of Innovative 2D Germanane-Silicane Alloys: SixGe1- xH Electrodes in Lithium-Ion Batteries.

The adjustable structures and remarkable physicochemical properties of 2D monoelemental materials, such as silicene and germanene, have attracted significant attention in recent years. They can be transformed into silicane (SiH) and germanane (GeH) through covalent functionalization via hydrogen atom termination. However, synthesizing these materials with a scalable and low-cost fabrication process to achieve high-quality 2D SiH and GeH poses challenges. Herein, groundbreaking 2D SiH and GeH materials with varying compositions, specifically Si0.25Ge0.75H, Si0.50Ge0.50H, and Si0.75Ge0.25H, are prepared through a simple and efficient chemical exfoliation of their Zintl phases. These 2D materials offer significant advantages, including their large surface area, high mechanical flexibility, rapid electron mobility, and defect-rich loose-layered structures. Among these compositions, the Si0.50Ge0.50H electrode demonstrates the highest discharge capacity, reaching up to 1059 mAh g-1 after 60 cycles at a current density of 75 mA g-1. A comprehensive ex-situ electrochemical analysis is conducted to investigate the reaction mechanisms of lithiation/delithiation in Si0.50Ge0.50H. Subsequently, an initial assessment of the c-Li15(SixGe1- x)4 phase after lithiation and the a-Si0.50Ge0.50 phase after delithiation is presented. Hence, this study contributes crucial insights into the (de)lithiation reaction mechanisms within germanane-silicane alloys. Such understanding is pivotal for mastering promising materials that amalgamate the finest properties of silicon and germanium.

Metal-organic pathways for anisotropic growth of a highly symmetrical crystal structure: example of the fcc Ni.

The control of the metallic nanocrystal shape is of prime importance for a wide variety of applications. We report a detailed research work on metal-organic chemical routes for the synthesis of a highly symmetrical crystal structure. In particular, this study shows the key parameters ensuring the anisotropic growth of nickel nanostructures (fcc crystal). Numerous reaction conditions are investigated (precursors, solvents, temperature, reducing agents, reaction time, and types and ratios of surfactants, such as alkyl amines, carboxylic acids, and phosphine oxides), and their effects on the size and shape of the final product are reported. The role of the growth modifiers and the structuring of the reaction media on the anisotropic growth are demonstrated. This metal-organic approach generates several novel anisotropic nanostructures in a wide size range depending on the reaction conditions. In this way, nanomaterials with reproducible size, shape, and composition are obtained with good yield. Transmission electron microscopy techniques (TEM and HRTEM) are the principal methods for monitoring the morphology.

Impact of Coated Zinc Oxide Nanoparticles on Photosystem II of Tomato Plants.

Zinc oxide nanoparticles (ZnO NPs) have emerged as a prominent tool in agriculture. Since photosynthetic function is a significant measurement of phytotoxicity and an assessment tool prior to large-scale agricultural applications, the impact of engineered irregular-shaped ZnO NPs coated with oleylamine (ZnO@OAm NPs) were tested. The ZnO@OAm NPs (crystalline size 19 nm) were solvothermally prepared in the sole presence of oleylamine (OAm) and evaluated on tomato (Lycopersicon esculentum Mill.) photosystem II (PSII) photochemistry. Foliar-sprayed 15 mg L-1 ZnO@OAm NPs on tomato leaflets increased chlorophyll content that initiated a higher amount of light energy capture, which resulted in about a 20% increased electron transport rate (ETR) and a quantum yield of PSII photochemistry (ΦPSII) at the growth light (GL, 600 µmol photons m-2 s-1). However, the ZnO@OAm NPs caused a malfunction in the oxygen-evolving complex (OEC) of PSII, which resulted in photoinhibition and increased ROS accumulation. The ROS accumulation was due to the decreased photoprotective mechanism of non-photochemical quenching (NPQ) and to the donor-side photoinhibition. Despite ROS accumulation, ZnO@OAm NPs decreased the excess excitation energy of the PSII, indicating improved PSII efficiency. Therefore, synthesized ZnO@OAm NPs can potentially be used as photosynthetic biostimulants for enhancing crop yields after being tested on other plant species.

Modification of Tomato Photosystem II Photochemistry with Engineered Zinc Oxide Nanorods.

We recently proposed the use of engineered irregularly shaped zinc oxide nanoparticles (ZnO NPs) coated with oleylamine (OAm), as photosynthetic biostimulants, to enhance crop yield. In the current research, we tested newly engineered rod-shaped ZnO nanorods (NRs) coated with oleylamine (ZnO@OAm NRs) regarding their in vivo behavior related to photosynthetic function and reactive oxygen species (ROS) generation in tomato (Lycopersicon esculentum Mill.) plants. ZnO@OAm NRs were produced via solvothermal synthesis. Their physicochemical assessment revealed a crystallite size of 15 nm, an organic coating of 8.7% w/w, a hydrodynamic diameter of 122 nm, and a ζ-potential of -4.8 mV. The chlorophyll content of tomato leaflets after a foliar spray with 15 mg L-1 ZnO@OAm NRs presented a hormetic response, with an increased content 30 min after the spray, which dropped to control levels 90 min after the spray. Simultaneously, 90 min after the spray, the efficiency of the oxygen-evolving complex (OEC) decreased significantly (p < 0.05) compared to control values, with a concomitant increase in ROS generation, a decrease in the maximum efficiency of PSII photochemistry (Fv/Fm), a decrease in the electron transport rate (ETR), and a decrease in the effective quantum yield of PSII photochemistry (ΦPSII), indicating reduced PSII efficiency. The decreased ETR and ΦPSII were due to the reduced efficiency of PSII reaction centers (Fv'/Fm'). There were no alterations in the excess excitation energy at PSII or the fraction of open PSII reaction centers (qp). We discovered that rod-shaped ZnO@OAm NRs reduced PSII photochemistry, in contrast to irregularly shaped ZnO@OAm NPs, which enhanced PSII efficiency. Thus, the shape and organic coating of the nanoparticles play a critical role in the mechanism of their action and their impact on crop yield when they are used in agriculture.

Nanocapsules of ZnO Nanorods and Geraniol as a Novel Mean for the Effective Control of Botrytis cinerea in Tomato and Cucumber Plants.

Inorganic-based nanoparticle formulations of bioactive compounds are a promising nanoscale application that allow agrochemicals to be entrapped and/or encapsulated, enabling gradual and targeted delivery of their active ingredients. In this context, hydrophobic ZnO@OAm nanorods (NRs) were firstly synthesized and characterized via physicochemical techniques and then encapsulated within the biodegradable and biocompatible sodium dodecyl sulfate (SDS), either separately (ZnO NCs) or in combination with geraniol in the effective ratios of 1:1 (ZnOGer1 NCs), 1:2 (ZnOGer2 NCs), and 1:3 (ZnOGer2 NCs), respectively. The mean hydrodynamic size, polydispersity index (PDI), and ζ-potential of the nanocapsules were determined at different pH values. The efficiency of encapsulation (EE, %) and loading capacity (LC, %) of NCs were also determined. Pharmacokinetics of ZnOGer1 NCs and ZnOGer2 NCs showed a sustainable release profile of geraniol over 96 h and a higher stability at 25 ± 0.5 °C rather than at 35 ± 0.5 °C. ZnOGer1 NCs, ZnOGer2 NCs and ZnO NCs were evaluated in vitro against B. cinerea, and EC50 values were calculated at 176 µg/mL, 150 µg/mL, and > 500 µg/mL, respectively. Subsequently, ZnOGer1 NCs and ZnOGer2 NCs were tested by foliar application on B. cinerea-inoculated tomato and cucumber plants, showing a significant reduction of disease severity. The foliar application of both NCs resulted in more effective inhibition of the pathogen in the infected cucumber plants as compared to the treatment with the chemical fungicide Luna Sensation SC. In contrast, tomato plants treated with ZnOGer2 NCs demonstrated a better inhibition of the disease as compared to the treatment with ZnOGer1 NCs and Luna. None of the treatments caused phytotoxic effects. These results support the potential for the use of the specific NCs as plant protection agents against B. cinerea in agriculture as an effective alternative to synthetic fungicides.

Enhanced detoxification of Cr6+ by Shewanella oneidensis via adsorption on spherical and flower-like manganese ferrite nanostructures.

Maximizing the safe removal of hexavalent chromium (Cr6+) from waste streams is an increasing demand due to the environmental, economic and health benefits. The integrated adsorption and bio-reduction method can be applied for the elimination of the highly toxic Cr6+ and its detoxification. This work describes a synthetic method for achieving the best chemical composition of spherical and flower-like manganese ferrite (MnxFe3-xO4) nanostructures (NS) for Cr6+ adsorption. We selected NS with the highest adsorption performance to study its efficiency in the extracellular reduction of Cr6+ into a trivalent state (Cr3+) by Shewanella oneidensis (S. oneidensis) MR-1. MnxFe3-xO4 NS were prepared by a polyol solvothermal synthesis process. They were characterised by powder X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectrometry (XPS), dynamic light scattering (DLS) and Fourier transform-infrared (FTIR) spectroscopy. The elemental composition of MnxFe3-xO4 was evaluated by inductively coupled plasma atomic emission spectroscopy. Our results reveal that the oxidation state of the manganese precursor significantly affects the Cr6+ adsorption efficiency of MnxFe3-xO4 NS. The best adsorption capacity for Cr6+ is 16.8 ± 1.6 mg Cr6+/g by the spherical Mn0.22+Fe2.83+O4 nanoparticles at pH 7, which is 1.4 times higher than that of Mn0.8Fe2.2O4 nanoflowers. This was attributed to the relative excess of divalent manganese in Mn0.22+Fe2.83+O4 based on our XPS analysis. The lethal concentration of Cr6+ for S. oneidensis MR-1 was 60 mg L-1 (determined by flow cytometry). The addition of Mn0.22+Fe2.83+O4 nanoparticles to S. oneidensis MR-1 enhanced the bio-reduction of Cr6+ 2.66 times compared to the presence of the bacteria alone. This work provides a cost-effective method for the removal of Cr6+ with a minimum amount of sludge production.

Correction: Enhanced detoxification of Cr6+ by Shewanella oneidensis via adsorption on spherical and flower-like manganese ferrite nanostructures.

[This corrects the article DOI: 10.1039/D2NA00691J.].

Chiral Au Nanorods: Synthesis, Chirality Origin, and Applications.

Chiral Au nanorods (c-Au NRs) with diverse architectures constitute an interesting nanospecies in the field of chiral nanophotonics. The numerous possible plasmonic behaviors of Au NRs can be coupled with chirality to initiate, tune, and amplify their chiroptical response. Interdisciplinary technologies have boosted the development of fabrication and applications of c-Au NRs. Herein, we have focused on the role of chirality in c-Au NRs which helps to manipulate the light-matter interaction in nontraditional ways. A broad overview on the chirality origin, chirality transfer, chiroptical activities, artificially synthetic methodologies, and circularly polarized applications of c-Au NRs will be summarized and discussed. A deeper understanding of light-matter interaction in c-Au NRs will help to manipulate the chirality at the nanoscale, reveal the natural evolution process taking place, and set up a series of circularly polarized applications.

Improved Electrochemical Performance of NTs-WS2@C Nanocomposites for Lithium-Ion and Sodium-Ion Batteries.

Even though WS2 nanotubes (NTs-WS2) have great potential as anode materials for lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs) thanks to their unusual layered structure, their conductivity and cycling stability are far from satisfactory. To tackle these issues, carbon-coated WS2 (NTs-WS2@C) nanocomposites were prepared through a facile synthesis method that involved precipitating a carbon precursor (20% sucrose) on WS2 nanotubes, followed by annealing treatment under an argon environment. Thanks to the presence of highly conductive and mechanically robust carbon on the outer surface, NTs-WS2@C nanocomposites show improved electrochemical performance compared with bare NTs-WS2. After 60 cycles at 80 mA g-1 current density, the cells display high capacities of 305 mAh g-1 in LIBs and 152 mAh g-1 in SIBs, respectively. As the current density increases to 600 mA g-1, it provides specific capacities of 209 and 115 mAh g-1, correspondingly. The enhanced electrochemical performance in LIBs and SIBs is primarily attributed to the synergistic effects of the tubular architecture of WS2, carbon network and stable nanocomposite structure, which can effectively constrain volume variation during the metal ions intercalation/deintercalation processes.

Coated Cu-doped ZnO and Cu nanoparticles as control agents against plant pathogenic fungi and nematodes.

In the current study, coated copper nanoparticles with polyethylene glycol 8000 (Cu@PEG NPs) and copper-doped zinc oxide nanoparticles with diethylene glycol (Cu-doped ZnO@DEG NPs) have been synthesized via solvothermal and microwave-assisted process, physicochemical characterized, and studied as nano-fungicides and nano-nematicides. Spheroidal Cu-doped ZnO@DEG NPs and urchin-like Cu@PEG NPs have been isolated with average crystallite sizes of 12 and 21 nm, respectively. The Cu doping (11.3 wt%) in ZnO lattice (88.7 wt%) was investigated by Rietveld refinement analysis and confirmed by X-ray Diffraction (XRD) and X-ray Photoelectron Spectroscopy (XPS). The Cu-doped ZnO@DEG and Cu@PEG NPs revealed a growth inhibition of fungi Botrytis cinerea (B. cinerea) and Sclerotinia sclerotiorum (S. sclerotiorum) and nematode paralysis of Meloidogyne javanica in a dose-dependent manner. Cu-doped ZnO@DEG NPs were more effective against M. javanica (EC50 = 2.60 µg/mL) than the Cu@PEG NPs (EC50 = 25 µg/mL). In contrast, the antifungal activity was approximately similar for both NPs, with EC50 values at 310 and 327 µg/mL against B. cinerea, respectively, and 260 and 278 µg/mL against S. sclerotiorum, respectively. Lettuce (Lactuca sativa) plants were inoculated with S. sclerotiorum or M. javanica and sprayed with either Cu-doped ZnO@DEG NPs or Cu@PEG NPs. The antifungal effect was evaluated based on a disease index (DI), and nematicidal activity was assessed based on the total number of galls and nematode females per root gram. NPs successfully inhibited the growth of both pathogens without causing phytotoxicity on lettuce. The DI were significantly decreased as compared to the positive control (DI = 5.2), estimated equal to 1.7, 2.9 and 2.5 for Cu@PEG NPs, Cu-doped ZnO@DEG NPs and the chemical control (KOCIDE 2000), respectively. The reduction in galling and population of M. javanica ranged from 39.32% to 32.29%, statistically like chemical control. The treatment of lettuce plants with Cu-doped ZnO@DEG NPs increased the leaf net photosynthetic value at 4.60 and 6.66 µmol CO2-2 s-1 in plants inoculated with S. sclerotiorum and M. javanica, respectively, as compared to the control (3.00 µmol CO2-2 s-1). The antioxidant capacity of NPs treated lettuce plants was evaluated as 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity in leaf extracts. Plants inoculated with S. sclerotiorum and sprayed with Cu-doped ZnO@DEG and Cu@PEG NPs, exhibited a 34.22% and 32.70% increase in antioxidant capacity, respectively, higher than the control. Similarly, an increase in antioxidant capacity was measured (39.49 and 37.36%) in lettuce inoculated with M. javanica and treated with Cu-doped ZnO@DEG and Cu@PEG NPs, respectively. Moreover, an increase of phenolic compounds in lettuce leaf tissue treated with NPs was measured as compared to the control. Overall, foliar applied Cu and Cu-doped ZnO NPs could be a promising tool to control phytopathogenic fungi and nematodes contributing to sustainability of agri-food sector.