RESUMO
Twenty patients with a variety of serious or difficult infections and 5 additional orthopaedic patients with clinical evidence of post-operative wound infection were treated with netilmicin. The results indicate that twice daily dosage with 150 mg intramuscularly, either alone or in combination with other antibiotic therapy, was highly effective. Overall, 25 (96%) infections responded clinically and 19 (73%) were improved bacteriologically. There was no evidence of ototoxicity: a number of patients had impaired renal function which developed during therapy, but all returned to normal or pre-treatment levels by the time that treatment was completed, despite the fact that 15 patients were receiving diuretics. It is suggested in view of its effectiveness, more predictable serum levels after standard dosage and apparent lack of toxicity, that netilmicin should be considered as the first choice aminoglycoside antibiotic instead of gentamicin.
Assuntos
Infecções Bacterianas/tratamento farmacológico , Gentamicinas/uso terapêutico , Netilmicina/uso terapêutico , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Netilmicina/sangue , Infecções Respiratórias/tratamento farmacológico , Infecções Urinárias/tratamento farmacológico , Infecção dos Ferimentos/tratamento farmacológicoRESUMO
Despite occasional reports of local success, the steadily increasing prevalence of strains of Staphylococcus aureus resistant to methicillin (MRSA) shows that attempts to limit their spread do not work. In this commentary we suggest that efforts to control the spread of methicillin-resistance are counterproductive, and that energies should instead be directed towards the control of outbreaks of disease and preventing the emergence of antibiotic resistance.
Assuntos
Infecção Hospitalar/prevenção & controle , Controle de Infecções/normas , Resistência a Meticilina , Infecções Estafilocócicas/prevenção & controle , Staphylococcus aureus/efeitos dos fármacos , Infecção Hospitalar/tratamento farmacológico , Guias como Assunto , Hospitais , Humanos , Infecções Estafilocócicas/tratamento farmacológico , Reino UnidoRESUMO
A total of thirty cases of sacral ana leg uleration, burns, and infected sinuses were treated with Debrisan in glycerine (4/1 v/v), after removal of adherent necrotic tissue surgically. The preparation was effective in cleansing the wound, in most cases reducing the bacterial colonization, and lessening the local inflammation and oedema. Production of healthy granulation tissue resulted and the lesions healed faster than expected. One-third of the lesions failed to respond to treatment, and the reasons for this are discussed. With some patient selection, this preparation proved to be valuable in the treatment of superficial ulcers and surgical wounds, in those lesions with sufficient exudate to enable Debrisan to act.
Assuntos
Bandagens , Dextranos/administração & dosagem , Úlcera Cutânea/terapia , Adulto , Idoso , Infecções Bacterianas/prevenção & controle , Queimaduras/terapia , Ensaios Clínicos como Assunto , Dextranos/uso terapêutico , Epicloroidrina/administração & dosagem , Epicloroidrina/uso terapêutico , Feminino , Glicerol , Humanos , Úlcera da Perna/microbiologia , Úlcera da Perna/terapia , Masculino , Pessoa de Meia-Idade , Úlcera por Pressão/terapia , Região Sacrococcígea , Úlcera Cutânea/microbiologia , Infecção dos Ferimentos/terapiaAssuntos
Fluoretação , Fluoretos/metabolismo , Dieta , Europa (Continente) , Humanos , Chá , Reino Unido , Estados Unidos , Água/metabolismoRESUMO
A total of 120 patients, including 53 pregnant women with significant bacteriuria, received 163 7-day courses of oral antimicrobial agents allocated in a randomised manner. The cure rates after 6 weeks' follow-up ranged from 73% to 86%, and there was no statistical difference between preparations of ampicillin, carbenicillin indanyl easter, and 2 different formulations of nifuratel. Side-effects occurred in 30% to 40% of the courses of penicillin drugs, but in under 15% of the course of nifuratel. It is concluded that the new oral preparation of carbenicillin is a useful addition to the list of antimicrobial agents which are effective in the treatment of urinary infections in domiciliary patients. Furthermore, nifuratel has been confirmed as a highly active non-toxic drug which is valuable in the treatment of urinary infections.
Assuntos
Ampicilina/uso terapêutico , Infecções Bacterianas/tratamento farmacológico , Carbenicilina , Carbenicilina/análogos & derivados , Nitrofuranos/uso terapêutico , Infecções Urinárias/tratamento farmacológico , Administração Oral , Ampicilina/administração & dosagem , Ampicilina/efeitos adversos , Bacteriúria/tratamento farmacológico , Carbenicilina/administração & dosagem , Carbenicilina/efeitos adversos , Carbenicilina/uso terapêutico , Ensaios Clínicos como Assunto , Infecções por Escherichia coli/tratamento farmacológico , Feminino , Humanos , Infecções por Klebsiella/tratamento farmacológico , Masculino , Nitrofuranos/administração & dosagem , Nitrofuranos/efeitos adversos , Gravidez , Infecções por Proteus/tratamento farmacológico , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estreptocócicas/tratamento farmacológico , Fatores de TempoRESUMO
The efficacy, tolerability and side effects of a 3-day treatment for acute urinary infection in general practice with norfloxacin (400 mg 12 hourly) or nalidixic acid/citrate (1 sachet 8 hourly) were compared in a randomized study. Patient groups had similar demography, symptomatology and initial infecting bacteria. Of the evaluable 55 patients in each treatment group with initial bacteriuria, 53 (96%) had no bacteriuria at immediate follow-up after treatment with norfloxacin and 45 (82%) with nalidixic acid/citrate. The corresponding rates at late follow-up were 40/45 (89%) and 29/43 (67%) (P less than 0.05). Among the bacteriuric patients a significantly greater proportion were recorded as having cured and improved symptoms. The tolerability of norfloxacin seemed to be better than that of nalidixic acid/citrate.