Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Phase variation as a major mechanism of adaptation in Mycobacterium tuberculosis complex.

Vargas, Roger; Luna, Michael J; Freschi, Luca; Marin, Maximillian; Froom, Ruby; Murphy, Kenan C; Campbell, Elizabeth A; Ioerger, Thomas R; Sassetti, Christopher M; Farhat, Maha Reda.

Proc Natl Acad Sci U S A ; 120(28): e2301394120, 2023 07 11.

Artigo em Inglês | MEDLINE | ID: mdl-37399390

2.

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.

Johnson, Eachan O; LaVerriere, Emily; Office, Emma; Stanley, Mary; Meyer, Elisabeth; Kawate, Tomohiko; Gomez, James E; Audette, Rebecca E; Bandyopadhyay, Nirmalya; Betancourt, Natalia; Delano, Kayla; Da Silva, Israel; Davis, Joshua; Gallo, Christina; Gardner, Michelle; Golas, Aaron J; Guinn, Kristine M; Kennedy, Sofia; Korn, Rebecca; McConnell, Jennifer A; Moss, Caitlin E; Murphy, Kenan C; Nietupski, Raymond M; Papavinasasundaram, Kadamba G; Pinkham, Jessica T; Pino, Paula A; Proulx, Megan K; Ruecker, Nadine; Song, Naomi; Thompson, Matthew; Trujillo, Carolina; Wakabayashi, Shoko; Wallach, Joshua B; Watson, Christopher; Ioerger, Thomas R; Lander, Eric S; Hubbard, Brian K; Serrano-Wu, Michael H; Ehrt, Sabine; Fitzgerald, Michael; Rubin, Eric J; Sassetti, Christopher M; Schnappinger, Dirk; Hung, Deborah T.

Nature ; 571(7763): 72-78, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31217586

3.

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.

Koh, Eun-Ik; Oluoch, Peter O; Ruecker, Nadine; Proulx, Megan K; Soni, Vijay; Murphy, Kenan C; Papavinasasundaram, Kadamba; Reames, Charlotte J; Trujillo, Carolina; Zaveri, Anisha; Zimmerman, Matthew D; Aslebagh, Roshanak; Baker, Richard E; Shaffer, Scott A; Guinn, Kristine M; Fitzgerald, Michael; Dartois, Véronique; Ehrt, Sabine; Hung, Deborah T; Ioerger, Thomas R; Rubin, Eric J; Rhee, Kyu Y; Schnappinger, Dirk; Sassetti, Christopher M.

Proc Natl Acad Sci U S A ; 119(15): e2201632119, 2022 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-35380903

4.

A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.

Sutiwisesak, Rujapak; Hicks, Nathan D; Boyce, Shayla; Murphy, Kenan C; Papavinasasundaram, Kadamba; Carpenter, Stephen M; Boucau, Julie; Joshi, Neelambari; Le Gall, Sylvie; Fortune, Sarah M; Sassetti, Christopher M; Behar, Samuel M.

PLoS Pathog ; 16(10): e1009000, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-33075106

5.

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.

Warrier, Thulasi; Kapilashrami, Kanishk; Argyrou, Argyrides; Ioerger, Thomas R; Little, David; Murphy, Kenan C; Nandakumar, Madhumitha; Park, Suna; Gold, Ben; Mi, Jianjie; Zhang, Tuo; Meiler, Eugenia; Rees, Mike; Somersan-Karakaya, Selin; Porras-De Francisco, Esther; Martinez-Hoyos, Maria; Burns-Huang, Kristin; Roberts, Julia; Ling, Yan; Rhee, Kyu Y; Mendoza-Losana, Alfonso; Luo, Minkui; Nathan, Carl F.

Proc Natl Acad Sci U S A ; 113(31): E4523-30, 2016 08 02.

Artigo em Inglês | MEDLINE | ID: mdl-27432954

6.

Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.

Prigozhin, Daniil M; Papavinasasundaram, Kadamba G; Baer, Christina E; Murphy, Kenan C; Moskaleva, Alisa; Chen, Tony Y; Alber, Tom; Sassetti, Christopher M.

J Biol Chem ; 291(44): 22961-22969, 2016 10 28.

Artigo em Inglês | MEDLINE | ID: mdl-27601474

7.

Subpolar addition of new cell wall is directed by DivIVA in mycobacteria.

Meniche, Xavier; Otten, Renee; Siegrist, M Sloan; Baer, Christina E; Murphy, Kenan C; Bertozzi, Carolyn R; Sassetti, Christopher M.

Proc Natl Acad Sci U S A ; 111(31): E3243-51, 2014 Aug 05.

Artigo em Inglês | MEDLINE | ID: mdl-25049412

8.

High incidence of multiple antibiotic resistant cells in cultures of in enterohemorrhagic Escherichia coli O157:H7.

Carone, Benjamin R; Xu, Tao; Murphy, Kenan C; Marinus, Martin G.

Mutat Res ; 759: 1-8, 2014 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24361397

9.

Identification of a novel prophage regulator in Escherichia coli controlling the expression of type III secretion.

Flockhart, Allen F; Tree, Jai J; Xu, Xuefang; Karpiyevich, Maryia; McAteer, Sean P; Rosenblum, Ronen; Shaw, Darren J; Low, Christopher J; Best, Angus; Gannon, Victor; Laing, Chad; Murphy, Kenan C; Leong, John M; Schneiders, Thamarai; La Ragione, Roberto; Gally, David L.

Mol Microbiol ; 83(1): 208-23, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22111928

10.

Structural/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function.

Murphy, Kenan C; Volkert, Michael R.

BMC Mol Biol ; 13: 26, 2012 Aug 08.

Artigo em Inglês | MEDLINE | ID: mdl-22873401

11.

Transcriptional regulators of the GAD acid stress island are carried by effector protein-encoding prophages and indirectly control type III secretion in enterohemorrhagic Escherichia coli O157:H7.

Tree, Jai J; Roe, Andrew J; Flockhart, Allen; McAteer, Sean P; Xu, Xuefang; Shaw, Darren; Mahajan, Arvind; Beatson, Scott A; Best, Angus; Lotz, Sabrina; Woodward, Martin J; La Ragione, Roberto; Murphy, Kenan C; Leong, John M; Gally, David L.

Mol Microbiol ; 80(5): 1349-65, 2011 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21492263

12.

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.

Smith, Clare M; Baker, Richard E; Proulx, Megan K; Mishra, Bibhuti B; Long, Jarukit E; Park, Sae Woong; Lee, Ha-Na; Kiritsy, Michael C; Bellerose, Michelle M; Olive, Andrew J; Murphy, Kenan C; Papavinasasundaram, Kadamba; Boehm, Frederick J; Reames, Charlotte J; Meade, Rachel K; Hampton, Brea K; Linnertz, Colton L; Shaw, Ginger D; Hock, Pablo; Bell, Timothy A; Ehrt, Sabine; Schnappinger, Dirk; Pardo-Manuel de Villena, Fernando; Ferris, Martin T; Ioerger, Thomas R; Sassetti, Christopher M.

Elife ; 112022 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-35112666

13.

Oligo-Mediated Recombineering and its Use for Making SNPs, Knockouts, Insertions, and Fusions in Mycobacterium tuberculosis.

Murphy, Kenan C.

Methods Mol Biol ; 2314: 301-321, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34235660

14.

The structure of the endogenous ESX-3 secretion system.

Poweleit, Nicole; Czudnochowski, Nadine; Nakagawa, Rachel; Trinidad, Donovan D; Murphy, Kenan C; Sassetti, Christopher M; Rosenberg, Oren S.

Elife ; 82019 12 30.

Artigo em Inglês | MEDLINE | ID: mdl-31886769

15.

Dam methyltransferase is required for stable lysogeny of the Shiga toxin (Stx2)-encoding bacteriophage 933W of enterohemorrhagic Escherichia coli O157:H7.

Murphy, Kenan C; Ritchie, Jennifer M; Waldor, Matthew K; Løbner-Olesen, Anders; Marinus, M G.

J Bacteriol ; 190(1): 438-41, 2008 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-17981979

16.

The lambda Gam protein inhibits RecBCD binding to dsDNA ends.

Murphy, Kenan C.

J Mol Biol ; 371(1): 19-24, 2007 Aug 03.

Artigo em Inglês | MEDLINE | ID: mdl-17583735

17.

ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes.

Murphy, Kenan C; Nelson, Samantha J; Nambi, Subhalaxmi; Papavinasasundaram, Kadamba; Baer, Christina E; Sassetti, Christopher M.

mBio ; 9(6)2018 12 11.

Artigo em Inglês | MEDLINE | ID: mdl-30538179

18.

λ Recombination and Recombineering.

Murphy, Kenan C.

EcoSal Plus ; 7(1)2016 05.

Artigo em Inglês | MEDLINE | ID: mdl-27223821

19.

Mycobacterial recombineering.

Murphy, Kenan C; Papavinasasundaram, Kadamba; Sassetti, Christopher M.

Methods Mol Biol ; 1285: 177-99, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25779316

20.

The Oxidative Stress Network of Mycobacterium tuberculosis Reveals Coordination between Radical Detoxification Systems.

Nambi, Subhalaxmi; Long, Jarukit E; Mishra, Bibhuti B; Baker, Richard; Murphy, Kenan C; Olive, Andrew J; Nguyen, Hien P; Shaffer, Scott A; Sassetti, Christopher M.

Cell Host Microbe ; 17(6): 829-37, 2015 Jun 10.

Artigo em Inglês | MEDLINE | ID: mdl-26067605

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Phase variation as a major mechanism of adaptation in Mycobacterium tuberculosis complex.

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.

A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.

Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.

Subpolar addition of new cell wall is directed by DivIVA in mycobacteria.

High incidence of multiple antibiotic resistant cells in cultures of in enterohemorrhagic Escherichia coli O157:H7.

Identification of a novel prophage regulator in Escherichia coli controlling the expression of type III secretion.

Structural/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function.

Transcriptional regulators of the GAD acid stress island are carried by effector protein-encoding prophages and indirectly control type III secretion in enterohemorrhagic Escherichia coli O157:H7.

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.

Oligo-Mediated Recombineering and its Use for Making SNPs, Knockouts, Insertions, and Fusions in Mycobacterium tuberculosis.

The structure of the endogenous ESX-3 secretion system.

Dam methyltransferase is required for stable lysogeny of the Shiga toxin (Stx2)-encoding bacteriophage 933W of enterohemorrhagic Escherichia coli O157:H7.

The lambda Gam protein inhibits RecBCD binding to dsDNA ends.

ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes.

λ Recombination and Recombineering.

Mycobacterial recombineering.

The Oxidative Stress Network of Mycobacterium tuberculosis Reveals Coordination between Radical Detoxification Systems.