Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Genomic analyses identify molecular subtypes of pancreatic cancer.

Bailey, Peter; Chang, David K; Nones, Katia; Johns, Amber L; Patch, Ann-Marie; Gingras, Marie-Claude; Miller, David K; Christ, Angelika N; Bruxner, Tim J C; Quinn, Michael C; Nourse, Craig; Murtaugh, L Charles; Harliwong, Ivon; Idrisoglu, Senel; Manning, Suzanne; Nourbakhsh, Ehsan; Wani, Shivangi; Fink, Lynn; Holmes, Oliver; Chin, Venessa; Anderson, Matthew J; Kazakoff, Stephen; Leonard, Conrad; Newell, Felicity; Waddell, Nick; Wood, Scott; Xu, Qinying; Wilson, Peter J; Cloonan, Nicole; Kassahn, Karin S; Taylor, Darrin; Quek, Kelly; Robertson, Alan; Pantano, Lorena; Mincarelli, Laura; Sanchez, Luis N; Evers, Lisa; Wu, Jianmin; Pinese, Mark; Cowley, Mark J; Jones, Marc D; Colvin, Emily K; Nagrial, Adnan M; Humphrey, Emily S; Chantrill, Lorraine A; Mawson, Amanda; Humphris, Jeremy; Chou, Angela; Pajic, Marina; Scarlett, Christopher J.

Nature ; 531(7592): 47-52, 2016 Mar 03.

Artigo em Inglês | MEDLINE | ID: mdl-26909576

2.

An inflammatory transcriptional switch.

Murtaugh, L Charles; MacDonald, Raymond J.

Nature ; 554(7693): 470-472, 2018 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-32094929

3.

An inflammatory transcriptional switch.

Murtaugh, L Charles; MacDonald, Raymond J.

Nature ; 554(7693): 470-472, 2018 02 22.

Artigo em Inglês | MEDLINE | ID: mdl-29469130

4.

Regeneration and repair of the exocrine pancreas.

Murtaugh, L Charles; Keefe, Matthew D.

Annu Rev Physiol ; 77: 229-49, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25386992

5.

Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.

Veniaminova, Natalia A; Vagnozzi, Alicia N; Kopinke, Daniel; Do, Thy Thy; Murtaugh, L Charles; Maillard, Ivan; Dlugosz, Andrzej A; Reiter, Jeremy F; Wong, Sunny Y.

Development ; 140(24): 4870-80, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-24198274

6.

Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis.

Bankhead, Elizabeth J; Colasanto, Mary P; Dyorich, Kayla M; Jamrich, Milan; Murtaugh, L Charles; Fuhrmann, Sabine.

Am J Pathol ; 185(1): 197-213, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25451153

7.

Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning.

Baumgartner, Brett K; Cash, Gabriela; Hansen, Hillary; Ostler, Shawn; Murtaugh, L Charles.

Dev Biol ; 391(1): 89-98, 2014 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-24721715

8.

A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers.

Murtaugh, L Charles; Leach, Steven D.

Cancer Cell ; 11(3): 211-3, 2007 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-17349578

9.

Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina.

Gordon, Patrick J; Yun, Sanghee; Clark, Anna M; Monuki, Edwin S; Murtaugh, L Charles; Levine, Edward M.

J Neurosci ; 33(30): 12197-207, 2013 Jul 24.

Artigo em Inglês | MEDLINE | ID: mdl-23884928

10.

Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas.

Kopinke, Daniel; Brailsford, Marisa; Shea, Jill E; Leavitt, Rebecca; Scaife, Courtney L; Murtaugh, L Charles.

Development ; 138(3): 431-41, 2011 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-21205788

11.

Pathogenesis of pancreatic cancer: lessons from animal models.

Murtaugh, L Charles.

Toxicol Pathol ; 42(1): 217-28, 2014 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24178582

12.

Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome.

Barrott, Jared J; Cash, Gabriela M; Smith, Aaron P; Barrow, Jeffery R; Murtaugh, L Charles.

Proc Natl Acad Sci U S A ; 108(31): 12752-7, 2011 Aug 02.

Artigo em Inglês | MEDLINE | ID: mdl-21768372

13.

Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.

Kopinke, Daniel; Brailsford, Marisa; Pan, Fong Cheng; Magnuson, Mark A; Wright, Christopher V E; Murtaugh, L Charles.

Dev Biol ; 362(1): 57-64, 2012 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-22146645

14.

Matters arising: Insufficient evidence that pancreatic ß cells are derived from adult ductal Neurog3-expressing progenitors.

Magenheim, Judith; Maestro, Miguel Angel; Sharon, Nadav; Herrera, Pedro L; Murtaugh, L Charles; Kopp, Janel; Sander, Maike; Gu, Guoqiang; Melton, Douglas A; Ferrer, Jorge; Dor, Yuval.

Cell Stem Cell ; 30(4): 488-497.e3, 2023 04 06.

Artigo em Inglês | MEDLINE | ID: mdl-37028408

15.

Key transcriptional effectors of the pancreatic acinar phenotype and oncogenic transformation.

Azevedo-Pouly, Ana; Hale, Michael A; Swift, Galvin H; Hoang, Chinh Q; Deering, Tye G; Xue, Jumin; Wilkie, Thomas M; Murtaugh, L Charles; MacDonald, Raymond J.

PLoS One ; 18(10): e0291512, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37796967

16.

Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.

Yun, Sanghee; Saijoh, Yukio; Hirokawa, Karla E; Kopinke, Daniel; Murtaugh, L Charles; Monuki, Edwin S; Levine, Edward M.

Development ; 136(23): 3895-906, 2009 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-19906857

17.

BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases ß cell mass.

Hill, Jennifer Hampton; Massaquoi, Michelle Sconce; Sweeney, Emily Goers; Wall, Elena S; Jahl, Philip; Bell, Rickesha; Kallio, Karen; Derrick, Daniel; Murtaugh, L Charles; Parthasarathy, Raghuveer; Remington, S James; Round, June L; Guillemin, Karen.

Cell Metab ; 34(11): 1779-1791.e9, 2022 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-36240759

18.

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia.

De La O, Jean-Paul; Emerson, Lyska L; Goodman, Jessica L; Froebe, Scott C; Illum, Benjamin E; Curtis, Andrew B; Murtaugh, L Charles.

Proc Natl Acad Sci U S A ; 105(48): 18907-12, 2008 Dec 02.

Artigo em Inglês | MEDLINE | ID: mdl-19028876

19.

Pathogenic effect of TP73 Gene Variants in People With Amyotrophic Lateral Sclerosis.

Russell, Kristi L; Downie, Jonathan M; Gibson, Summer B; Tsetsou, Spyridoula; Keefe, Matthew D; Duran, Jerry A; Figueroa, Karla P; Bromberg, Mark B; Murtaugh, L Charles; Bonkowsky, Joshua L; Pulst, Stefan M; Jorde, Lynn B.

Neurology ; 2021 Jun 16.

Artigo em Inglês | MEDLINE | ID: mdl-34135078

20.

Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas.

Kopinke, Daniel; Murtaugh, L Charles.

BMC Dev Biol ; 10: 38, 2010 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-20377894

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Genomic analyses identify molecular subtypes of pancreatic cancer.

An inflammatory transcriptional switch.

An inflammatory transcriptional switch.

Regeneration and repair of the exocrine pancreas.

Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.

Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis.

Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning.

A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers.

Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina.

Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas.

Pathogenesis of pancreatic cancer: lessons from animal models.

Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome.

Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.

Matters arising: Insufficient evidence that pancreatic ß cells are derived from adult ductal Neurog3-expressing progenitors.

Key transcriptional effectors of the pancreatic acinar phenotype and oncogenic transformation.

Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.

BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases ß cell mass.

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia.

Pathogenic effect of TP73 Gene Variants in People With Amyotrophic Lateral Sclerosis.

Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas.