Detalhe da pesquisa
1.
First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G-protein-biased sphingosine-1 phosphate receptor-1 agonist for endothelial protection.
Br J Clin Pharmacol
; 87(2): 598-611, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32520410
2.
Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled patient trial.
Br J Clin Pharmacol
; 87(5): 2303-2320, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33125753
3.
RGS4 inhibits angiotensin II signaling and macrophage localization during renal reperfusion injury independent of vasospasm.
Kidney Int
; 87(4): 771-83, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25469849
4.
RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation.
Am J Physiol Lung Cell Mol Physiol
; 305(10): L693-701, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24077945
5.
TRB3 function in cardiac endoplasmic reticulum stress.
Circ Res
; 106(9): 1516-23, 2010 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20360254
6.
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.
Cell Metab
; 4(5): 377-89, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17084711
7.
RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury.
Kidney Int
; 80(3): 263-71, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21412219
8.
Attenuation of CHOP-mediated myocardial apoptosis in pressure-overloaded dominant negative p38α mitogen-activated protein kinase mice.
Cell Physiol Biochem
; 27(5): 487-96, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21691066
9.
An unbiased chemical biology screen identifies agents that modulate uptake of oxidized LDL by macrophages.
Circ Res
; 105(2): 148-57, 2009 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19542016
10.
Akt2: a critical regulator of cardiomyocyte survival and metabolism.
Pediatr Cardiol
; 32(3): 317-22, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21279637
11.
Akt2 deficiency promotes cardiac induction of Rab4a and myocardial ß-adrenergic hypersensitivity.
J Mol Cell Cardiol
; 49(6): 931-40, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20728450
12.
Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels.
J Biol Chem
; 284(47): 32434-43, 2009 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19767393
13.
Partial inactivation of cardiac 14-3-3 protein in vivo elicits endoplasmic reticulum stress (ERS) and activates ERS-initiated apoptosis in ERS-induced mice.
Cell Physiol Biochem
; 26(2): 167-78, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20798500
14.
The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival.
Mol Cell Biol
; 27(4): 1455-66, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17145769
15.
14-3-3 protein protects against cardiac endoplasmic reticulum stress (ERS) and ERS-initiated apoptosis in experimental diabetes.
J Pharmacol Sci
; 113(4): 325-34, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20644335
16.
A G protein-biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers.
Sci Signal
; 13(634)2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32487716
17.
Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy.
Cardiovasc Res
; 116(2): 329-338, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31038167
18.
Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury.
Circulation
; 118(6): 658-66, 2008 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18645058
19.
Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling.
Dev Cell
; 2(5): 567-78, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12015965
20.
Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure.
Kidney Int
; 75(8): 800-8, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19165175