Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site.

Kanekiyo, Masaru; Bu, Wei; Joyce, M Gordon; Meng, Geng; Whittle, James R R; Baxa, Ulrich; Yamamoto, Takuya; Narpala, Sandeep; Todd, John-Paul; Rao, Srinivas S; McDermott, Adrian B; Koup, Richard A; Rossmann, Michael G; Mascola, John R; Graham, Barney S; Cohen, Jeffrey I; Nabel, Gary J.

Cell ; 162(5): 1090-100, 2015 Aug 27.

Artigo em Inglês | MEDLINE | ID: mdl-26279189

2.

Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells.

Bu, Wei; Joyce, M Gordon; Nguyen, Hanh; Banh, Dalton V; Aguilar, Fiona; Tariq, Zeshan; Yap, Moh Lan; Tsujimura, Yusuke; Gillespie, Rebecca A; Tsybovsky, Yaroslav; Andrews, Sarah F; Narpala, Sandeep R; McDermott, Adrian B; Rossmann, Michael G; Yasutomi, Yasuhiro; Nabel, Gary J; Kanekiyo, Masaru; Cohen, Jeffrey I.

Immunity ; 50(5): 1305-1316.e6, 2019 05 21.

Artigo em Inglês | MEDLINE | ID: mdl-30979688

3.

A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells.

Seung, Edward; Xing, Zhen; Wu, Lan; Rao, Ercole; Cortez-Retamozo, Virna; Ospina, Beatriz; Chen, Liqing; Beil, Christian; Song, Zhili; Zhang, Bailin; Levit, Mikhail; Deng, Gejing; Hebert, Andrew; Kirby, Patrick; Li, Aiqun; Poulton, Emma-Jane; Vicente, Rita; Garrigou, Audrey; Piepenhagen, Peter; Ulinski, Greg; Sanicola-Nadel, Michele; Bangari, Dinesh S; Qiu, Huawei; Pao, Lily; Wiederschain, Dmitri; Wei, Ronnie; Yang, Zhi-Yong; Nabel, Gary J.

Nature ; 603(7900): 328-334, 2022 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-35197632

4.

Publisher Correction: A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells.

Seung, Edward; Xing, Zhen; Wu, Lan; Rao, Ercole; Cortez-Retamozo, Virna; Ospina, Beatriz; Chen, Liqing; Beil, Christian; Song, Zhili; Zhang, Bailin; Levit, Mikhail; Deng, Gejing; Hebert, Andrew; Kirby, Patrick; Li, Aiqun; Poulton, Emma-Jane; Vicente, Rita; Garrigou, Audrey; Piepenhagen, Peter; Ulinski, Greg; Sanicola-Nadel, Michele; Bangari, Dinesh S; Qiu, Huawei; Pao, Lily; Wiederschain, Dmitri; Wei, Ronnie; Yang, Zhi-Yong; Nabel, Gary J.

Nature ; 604(7905): E13, 2022 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-35332336

5.

Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.

Zhou, Tongqing; Zhu, Jiang; Wu, Xueling; Moquin, Stephanie; Zhang, Baoshan; Acharya, Priyamvada; Georgiev, Ivelin S; Altae-Tran, Han R; Chuang, Gwo-Yu; Joyce, M Gordon; Kwon, Young Do; Longo, Nancy S; Louder, Mark K; Luongo, Timothy; McKee, Krisha; Schramm, Chaim A; Skinner, Jeff; Yang, Yongping; Yang, Zhongjia; Zhang, Zhenhai; Zheng, Anqi; Bonsignori, Mattia; Haynes, Barton F; Scheid, Johannes F; Nussenzweig, Michel C; Simek, Melissa; Burton, Dennis R; Koff, Wayne C; Mullikin, James C; Connors, Mark; Shapiro, Lawrence; Nabel, Gary J; Mascola, John R; Kwong, Peter D.

Immunity ; 39(2): 245-58, 2013 Aug 22.

Artigo em Inglês | MEDLINE | ID: mdl-23911655

6.

Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.

Liao, Hua-Xin; Bonsignori, Mattia; Alam, S Munir; McLellan, Jason S; Tomaras, Georgia D; Moody, M Anthony; Kozink, Daniel M; Hwang, Kwan-Ki; Chen, Xi; Tsao, Chun-Yen; Liu, Pinghuang; Lu, Xiaozhi; Parks, Robert J; Montefiori, David C; Ferrari, Guido; Pollara, Justin; Rao, Mangala; Peachman, Kristina K; Santra, Sampa; Letvin, Norman L; Karasavvas, Nicos; Yang, Zhi-Yong; Dai, Kaifan; Pancera, Marie; Gorman, Jason; Wiehe, Kevin; Nicely, Nathan I; Rerks-Ngarm, Supachai; Nitayaphan, Sorachai; Kaewkungwal, Jaranit; Pitisuttithum, Punnee; Tartaglia, James; Sinangil, Faruk; Kim, Jerome H; Michael, Nelson L; Kepler, Thomas B; Kwong, Peter D; Mascola, John R; Nabel, Gary J; Pinter, Abraham; Zolla-Pazner, Susan; Haynes, Barton F.

Immunity ; 38(1): 176-86, 2013 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-23313589

7.

All for one and one for all to fight flu.

Nabel, Gary J; Shiver, John W.

Nature ; 565(7737): 29-31, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30573785

8.

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection.

Ko, Sung-Youl; Pegu, Amarendra; Rudicell, Rebecca S; Yang, Zhi-yong; Joyce, M Gordon; Chen, Xuejun; Wang, Keyun; Bao, Saran; Kraemer, Thomas D; Rath, Timo; Zeng, Ming; Schmidt, Stephen D; Todd, John-Paul; Penzak, Scott R; Saunders, Kevin O; Nason, Martha C; Haase, Ashley T; Rao, Srinivas S; Blumberg, Richard S; Mascola, John R; Nabel, Gary J.

Nature ; 514(7524): 642-5, 2014 Oct 30.

Artigo em Inglês | MEDLINE | ID: mdl-25119033

9.

Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.

Roederer, Mario; Keele, Brandon F; Schmidt, Stephen D; Mason, Rosemarie D; Welles, Hugh C; Fischer, Will; Labranche, Celia; Foulds, Kathryn E; Louder, Mark K; Yang, Zhi-Yong; Todd, John-Paul M; Buzby, Adam P; Mach, Linh V; Shen, Ling; Seaton, Kelly E; Ward, Brandy M; Bailer, Robert T; Gottardo, Raphael; Gu, Wenjuan; Ferrari, Guido; Alam, S Munir; Denny, Thomas N; Montefiori, David C; Tomaras, Georgia D; Korber, Bette T; Nason, Martha C; Seder, Robert A; Koup, Richard A; Letvin, Norman L; Rao, Srinivas S; Nabel, Gary J; Mascola, John R.

Nature ; 505(7484): 502-8, 2014 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-24352234

10.

Development of a Pan-H1 Influenza Vaccine.

Darricarrère, Nicole; Pougatcheva, Svetlana; Duan, Xiaochu; Rudicell, Rebecca S; Chou, Te-Hui; DiNapoli, Joshua; Ross, Ted M; Alefantis, Tim; Vogel, Thorsten U; Kleanthous, Harry; Wei, Chih-Jen; Nabel, Gary J.

J Virol ; 92(22)2018 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-30185594

11.

HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration.

Cooper, Arik; García, Mayra; Petrovas, Constantinos; Yamamoto, Takuya; Koup, Richard A; Nabel, Gary J.

Nature ; 498(7454): 376-9, 2013 Jun 20.

Artigo em Inglês | MEDLINE | ID: mdl-23739328

12.

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies.

Kanekiyo, Masaru; Wei, Chih-Jen; Yassine, Hadi M; McTamney, Patrick M; Boyington, Jeffrey C; Whittle, James R R; Rao, Srinivas S; Kong, Wing-Pui; Wang, Lingshu; Nabel, Gary J.

Nature ; 499(7456): 102-6, 2013 Jul 04.

Artigo em Inglês | MEDLINE | ID: mdl-23698367

13.

Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-ß burden in several amyloid transgenic mouse models.

Latta-Mahieu, Martine; Elmer, Bradford; Bretteville, Alexis; Wang, Yaming; Lopez-Grancha, Mati; Goniot, Philippe; Moindrot, Nicolas; Ferrari, Paul; Blanc, Véronique; Schussler, Nathalie; Brault, Emmanuel; Roudières, Valérie; Blanchard, Véronique; Yang, Zhi-Yong; Barneoud, Pascal; Bertrand, Philippe; Roucourt, Bart; Carmans, Sofie; Bottelbergs, Astrid; Mertens, Liesbeth; Wintmolders, Cindy; Larsen, Peter; Hersley, Caroline; McGathey, Tyler; Racke, Margaret M; Liu, Ling; Lu, Jirong; O'Neill, Michael J; Riddell, David R; Ebneth, Andreas; Nabel, Gary J; Pradier, Laurent.

Glia ; 66(3): 492-504, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29134678

14.

Structural and genetic basis for development of broadly neutralizing influenza antibodies.

Lingwood, Daniel; McTamney, Patrick M; Yassine, Hadi M; Whittle, James R R; Guo, Xiaoti; Boyington, Jeffrey C; Wei, Chih-Jen; Nabel, Gary J.

Nature ; 489(7417): 566-70, 2012 Sep 27.

Artigo em Inglês | MEDLINE | ID: mdl-22932267

15.

H5N1 Vaccine-Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin Stem.

Wheatley, Adam K; Whittle, James R R; Lingwood, Daniel; Kanekiyo, Masaru; Yassine, Hadi M; Ma, Steven S; Narpala, Sandeep R; Prabhakaran, Madhu S; Matus-Nicodemos, Rodrigo A; Bailer, Robert T; Nabel, Gary J; Graham, Barney S; Ledgerwood, Julie E; Koup, Richard A; McDermott, Adrian B.

J Immunol ; 195(2): 602-10, 2015 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-26078272

16.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.

McLellan, Jason S; Pancera, Marie; Carrico, Chris; Gorman, Jason; Julien, Jean-Philippe; Khayat, Reza; Louder, Robert; Pejchal, Robert; Sastry, Mallika; Dai, Kaifan; O'Dell, Sijy; Patel, Nikita; Shahzad-ul-Hussan, Syed; Yang, Yongping; Zhang, Baoshan; Zhou, Tongqing; Zhu, Jiang; Boyington, Jeffrey C; Chuang, Gwo-Yu; Diwanji, Devan; Georgiev, Ivelin; Kwon, Young Do; Lee, Doyung; Louder, Mark K; Moquin, Stephanie; Schmidt, Stephen D; Yang, Zhi-Yong; Bonsignori, Mattia; Crump, John A; Kapiga, Saidi H; Sam, Noel E; Haynes, Barton F; Burton, Dennis R; Koff, Wayne C; Walker, Laura M; Phogat, Sanjay; Wyatt, Richard; Orwenyo, Jared; Wang, Lai-Xi; Arthos, James; Bewley, Carole A; Mascola, John R; Nabel, Gary J; Schief, William R; Ward, Andrew B; Wilson, Ian A; Kwong, Peter D.

Nature ; 480(7377): 336-43, 2011 Nov 23.

Artigo em Inglês | MEDLINE | ID: mdl-22113616

17.

Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial.

Kibuuka, Hannah; Berkowitz, Nina M; Millard, Monica; Enama, Mary E; Tindikahwa, Allan; Sekiziyivu, Arthur B; Costner, Pamela; Sitar, Sandra; Glover, Deline; Hu, Zonghui; Joshi, Gyan; Stanley, Daphne; Kunchai, Meghan; Eller, Leigh Anne; Bailer, Robert T; Koup, Richard A; Nabel, Gary J; Mascola, John R; Sullivan, Nancy J; Graham, Barney S; Roederer, Mario; Michael, Nelson L; Robb, Merlin L; Ledgerwood, Julie E.

Lancet ; 385(9977): 1545-54, 2015 Apr 18.

Artigo em Inglês | MEDLINE | ID: mdl-25540891

18.

Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine.

Hammer, Scott M; Sobieszczyk, Magdalena E; Janes, Holly; Karuna, Shelly T; Mulligan, Mark J; Grove, Doug; Koblin, Beryl A; Buchbinder, Susan P; Keefer, Michael C; Tomaras, Georgia D; Frahm, Nicole; Hural, John; Anude, Chuka; Graham, Barney S; Enama, Mary E; Adams, Elizabeth; DeJesus, Edwin; Novak, Richard M; Frank, Ian; Bentley, Carter; Ramirez, Shelly; Fu, Rong; Koup, Richard A; Mascola, John R; Nabel, Gary J; Montefiori, David C; Kublin, James; McElrath, M Juliana; Corey, Lawrence; Gilbert, Peter B.

N Engl J Med ; 369(22): 2083-92, 2013 Nov 28.

Artigo em Inglês | MEDLINE | ID: mdl-24099601

19.

Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection.

Saunders, Kevin O; Pegu, Amarendra; Georgiev, Ivelin S; Zeng, Ming; Joyce, M Gordon; Yang, Zhi-Yong; Ko, Sung-Youl; Chen, Xuejun; Schmidt, Stephen D; Haase, Ashley T; Todd, John-Paul; Bao, Saran; Kwong, Peter D; Rao, Srinivas S; Mascola, John R; Nabel, Gary J.

J Virol ; 89(11): 5895-903, 2015 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-25787288

20.

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection.

Saunders, Kevin O; Wang, Lingshu; Joyce, M Gordon; Yang, Zhi-Yong; Balazs, Alejandro B; Cheng, Cheng; Ko, Sung-Youl; Kong, Wing-Pui; Rudicell, Rebecca S; Georgiev, Ivelin S; Duan, Lijie; Foulds, Kathryn E; Donaldson, Mitzi; Xu, Ling; Schmidt, Stephen D; Todd, John-Paul; Baltimore, David; Roederer, Mario; Haase, Ashley T; Kwong, Peter D; Rao, Srinivas S; Mascola, John R; Nabel, Gary J.

J Virol ; 89(16): 8334-45, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-26041300

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