Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS.

Factor, Daniel C; Barbeau, Anna M; Allan, Kevin C; Hu, Lucille R; Madhavan, Mayur; Hoang, An T; Hazel, Kathryn E A; Hall, Parker A; Nisraiyya, Sagar; Najm, Fadi J; Miller, Tyler E; Nevin, Zachary S; Karl, Robert T; Lima, Bruna R; Song, Yanwei; Sibert, Alexandra G; Dhillon, Gursimran K; Volsko, Christina; Bartels, Cynthia F; Adams, Drew J; Dutta, Ranjan; Gallagher, Michael D; Phu, William; Kozlenkov, Alexey; Dracheva, Stella; Scacheri, Peter C; Tesar, Paul J; Corradin, Olivia.

Cell ; 181(2): 382-395.e21, 2020 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-32246942

2.

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.

Najm, Fadi J; Madhavan, Mayur; Zaremba, Anita; Shick, Elizabeth; Karl, Robert T; Factor, Daniel C; Miller, Tyler E; Nevin, Zachary S; Kantor, Christopher; Sargent, Alex; Quick, Kevin L; Schlatzer, Daniela M; Tang, Hong; Papoian, Ruben; Brimacombe, Kyle R; Shen, Min; Boxer, Matthew B; Jadhav, Ajit; Robinson, Andrew P; Podojil, Joseph R; Miller, Stephen D; Miller, Robert H; Tesar, Paul J.

Nature ; 522(7555): 216-20, 2015 Jun 11.

Artigo em Inglês | MEDLINE | ID: mdl-25896324

3.

Renewing your HBO1 subscription.

Najm, Fadi J; van Galen, Peter.

Blood ; 139(6): 802-804, 2022 02 10.

Artigo em Inglês | MEDLINE | ID: mdl-35142852

4.

Depletion of Olig2 in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus.

Benner, Bayleigh; Martorell, Anthony J; Mahadevan, Padmanabhan; Najm, Fadi J; Tesar, Paul J; Freundt, Eric C.

J Neurovirol ; 22(3): 336-48, 2016 06.

Artigo em Inglês | MEDLINE | ID: mdl-26631080

5.

Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells.

Najm, Fadi J; Zaremba, Anita; Caprariello, Andrew V; Nayak, Shreya; Freundt, Eric C; Scacheri, Peter C; Miller, Robert H; Tesar, Paul J.

Nat Methods ; 8(11): 957-62, 2011 Sep 25.

Artigo em Inglês | MEDLINE | ID: mdl-21946668

6.

Integrative dissection of gene regulatory elements at base resolution.

Chen, Zeyu; Javed, Nauman; Moore, Molly; Wu, Jingyi; Sun, Gary; Vinyard, Michael; Collins, Alejandro; Pinello, Luca; Najm, Fadi J; Bernstein, Bradley E.

Cell Genom ; 3(6): 100318, 2023 Jun 14.

Artigo em Inglês | MEDLINE | ID: mdl-37388913

7.

Chromatin complex dependencies reveal targeting opportunities in leukemia.

Najm, Fadi J; DeWeirdt, Peter; Moore, Molly M; Bevill, Samantha M; El Farran, Chadi A; Macias, Kevin A; Hegde, Mudra; Waterbury, Amanda L; Liau, Brian B; van Galen, Peter; Doench, John G; Bernstein, Bradley E.

Nat Commun ; 14(1): 448, 2023 01 27.

Artigo em Inglês | MEDLINE | ID: mdl-36707513

8.

Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcoma.

Bevill, Samantha M; Casaní-Galdón, Salvador; El Farran, Chadi A; Cytrynbaum, Eli G; Macias, Kevin A; Oldeman, Sylvie E; Oliveira, Kayla J; Moore, Molly M; Hegazi, Esmat; Adriaens, Carmen; Najm, Fadi J; Demetri, George D; Cohen, Sonia; Mullen, John T; Riggi, Nicolò; Johnstone, Sarah E; Bernstein, Bradley E.

Cell Genom ; 3(7): 100321, 2023 Jul 12.

Artigo em Inglês | MEDLINE | ID: mdl-37492096

9.

Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements.

Battaglia, Sofia; Dong, Kevin; Wu, Jingyi; Chen, Zeyu; Najm, Fadi J; Zhang, Yuanyuan; Moore, Molly M; Hecht, Vivian; Shoresh, Noam; Bernstein, Bradley E.

Nat Genet ; 54(10): 1504-1513, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-36195755

10.

Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP.

Allimuthu, Dharmaraja; Hubler, Zita; Najm, Fadi J; Tang, Hong; Bederman, Ilya; Seibel, William; Tesar, Paul J; Adams, Drew J.

Cell Chem Biol ; 26(4): 593-599.e4, 2019 04 18.

Artigo em Inglês | MEDLINE | ID: mdl-30773481

11.

Retraction Notice to: NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells.

Boles, Nathan C; Hirsch, Sarah E; Le, Sheila; Corneo, Barbara; Najm, Fadi; Minotti, Andrew P; Wang, Qingjie; Lotz, Steven; Tesar, Paul J; Fasano, Christopher A.

Cell Rep ; 43(1): 113625, 2024 01 23.

Artigo em Inglês | MEDLINE | ID: mdl-38127623

12.

Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens.

Najm, Fadi J; Strand, Christine; Donovan, Katherine F; Hegde, Mudra; Sanson, Kendall R; Vaimberg, Emma W; Sullender, Meagan E; Hartenian, Ella; Kalani, Zohra; Fusi, Nicolo; Listgarten, Jennifer; Younger, Scott T; Bernstein, Bradley E; Root, David E; Doench, John G.

Nat Biotechnol ; 36(2): 179-189, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-29251726

13.

Nucleolar asymmetry and the importance of septin integrity upon cell cycle arrest.

Rai, Urvashi; Najm, Fadi; Tartakoff, Alan M.

PLoS One ; 12(3): e0174306, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-28339487

14.

Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.

Liau, Brian B; Sievers, Cem; Donohue, Laura K; Gillespie, Shawn M; Flavahan, William A; Miller, Tyler E; Venteicher, Andrew S; Hebert, Christine H; Carey, Christopher D; Rodig, Scott J; Shareef, Sarah J; Najm, Fadi J; van Galen, Peter; Wakimoto, Hiroaki; Cahill, Daniel P; Rich, Jeremy N; Aster, Jon C; Suvà, Mario L; Patel, Anoop P; Bernstein, Bradley E.

Cell Stem Cell ; 20(2): 233-246.e7, 2017 02 02.

Artigo em Inglês | MEDLINE | ID: mdl-27989769

15.

NPTX1 regulates neural lineage specification from human pluripotent stem cells.

Boles, Nathan C; Hirsch, Sarah E; Le, Sheila; Corneo, Barbara; Najm, Fadi; Minotti, Andrew P; Wang, Qingjie; Lotz, Steven; Tesar, Paul J; Fasano, Christopher A.

Cell Rep ; 6(4): 724-36, 2014 Feb 27.

Artigo em Inglês | MEDLINE | ID: mdl-24529709

16.

Generation and characterization of epiblast stem cells from blastocyst-stage mouse embryos.

Factor, Daniel C; Najm, Fadi J; Tesar, Paul J.

Methods Mol Biol ; 1074: 1-13, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23975801

17.

Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.

Najm, Fadi J; Lager, Angela M; Zaremba, Anita; Wyatt, Krysta; Caprariello, Andrew V; Factor, Daniel C; Karl, Robert T; Maeda, Tadao; Miller, Robert H; Tesar, Paul J.

Nat Biotechnol ; 31(5): 426-33, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23584611

18.

Isolation of epiblast stem cells from preimplantation mouse embryos.

Najm, Fadi J; Chenoweth, Josh G; Anderson, Philip D; Nadeau, Joseph H; Redline, Raymond W; McKay, Ronald D G; Tesar, Paul J.

Cell Stem Cell ; 8(3): 318-25, 2011 Mar 04.

Artigo em Inglês | MEDLINE | ID: mdl-21362571

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