Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Beta-hairpin hydrogels as scaffolds for high-throughput drug discovery in three-dimensional cell culture.

Worthington, Peter; Drake, Katherine M; Li, Zhiqin; Napper, Andrew D; Pochan, Darrin J; Langhans, Sigrid A.

Anal Biochem ; 535: 25-34, 2017 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-28757092

2.

Perspectives on phenotypic screening-Screen Design and Assay Technology Special Interest Group.

Pak, Chorom; Simpson, Kaylene J; Weston, Andrea D; Cvijic, Mary Ellen; Evans, Kenda; Napper, Andrew D.

SLAS Discov ; 29(2): 100146, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38311110

3.

Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms.

LaFleur, Michael D; Lucumi, Edinson; Napper, Andrew D; Diamond, Scott L; Lewis, Kim.

J Antimicrob Chemother ; 66(4): 820-6, 2011 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-21393183

4.

Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.

Lucumi, Edinson; Darling, Claire; Jo, Hyunil; Napper, Andrew D; Chandramohanadas, Rajesh; Fisher, Nicholas; Shone, Alison E; Jing, Huiyan; Ward, Stephen A; Biagini, Giancarlo A; DeGrado, William F; Diamond, Scott L; Greenbaum, Doron C.

Antimicrob Agents Chemother ; 54(9): 3597-604, 2010 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-20547797

5.

Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC).

Sivendran, Sharmila; Jones, Victoria; Sun, Dianqing; Wang, Yi; Grzegorzewicz, Anna E; Scherman, Michael S; Napper, Andrew D; McCammon, J Andrew; Lee, Richard E; Diamond, Scott L; McNeil, Michael.

Bioorg Med Chem ; 18(2): 896-908, 2010 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-19969466

6.

Implementation of a High-Throughput Pilot Screen in Peptide Hydrogel-Based Three-Dimensional Cell Cultures.

Worthington, Peter; Drake, Katherine M; Li, Zhiqin; Napper, Andrew D; Pochan, Darrin J; Langhans, Sigrid A.

SLAS Discov ; 24(7): 714-723, 2019 08.

Artigo em Inglês | MEDLINE | ID: mdl-31039326

7.

Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L.

Shah, Parag P; Myers, Michael C; Beavers, Mary Pat; Purvis, Jeremy E; Jing, Huiyan; Grieser, Heather J; Sharlow, Elizabeth R; Napper, Andrew D; Huryn, Donna M; Cooperman, Barry S; Smith, Amos B; Diamond, Scott L.

Mol Pharmacol ; 74(1): 34-41, 2008 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-18403718

8.

Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases.

Motlekar, Nuzhat; Diamond, Scott L; Napper, Andrew D.

Assay Drug Dev Technol ; 6(3): 395-405, 2008 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-18593377

9.

Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype.

Myers, Michael C; Shah, Parag P; Beavers, Mary Pat; Napper, Andrew D; Diamond, Scott L; Smith, Amos B; Huryn, Donna M.

Bioorg Med Chem Lett ; 18(12): 3646-51, 2008 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-18499453

10.

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.

Coussens, Nathan P; Sittampalam, G Sitta; Guha, Rajarshi; Brimacombe, Kyle; Grossman, Abigail; Chung, Thomas D Y; Weidner, Jeffrey R; Riss, Terry; Trask, O Joseph; Auld, Douglas; Dahlin, Jayme L; Devanaryan, Viswanath; Foley, Timothy L; McGee, James; Kahl, Steven D; Kales, Stephen C; Arkin, Michelle; Baell, Jonathan; Bejcek, Bruce; Gal-Edd, Neely; Glicksman, Marcie; Haas, Joseph V; Iversen, Philip W; Hoeppner, Marilu; Lathrop, Stacy; Sayers, Eric; Liu, Hanguan; Trawick, Bart; McVey, Julie; Lemmon, Vance P; Li, Zhuyin; McManus, Owen; Minor, Lisa; Napper, Andrew; Wildey, Mary Jo; Pacifici, Robert; Chin, William W; Xia, Menghang; Xu, Xin; Lal-Nag, Madhu; Hall, Matthew D; Michael, Sam; Inglese, James; Simeonov, Anton; Austin, Christopher P.

Clin Transl Sci ; 11(5): 461-470, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-29877628

11.

Cytotoxicity of Zardaverine in Embryonal Rhabdomyosarcoma from a Costello Syndrome Patient.

Cartledge, Donna M; Robbins, Katherine M; Drake, Katherine M; Sternberg, Rachel; Stabley, Deborah L; Gripp, Karen W; Kolb, E Anders; Sol-Church, Katia; Napper, Andrew D.

Front Oncol ; 7: 42, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-28421158

12.

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

Napper, Andrew D; Hixon, Jeffrey; McDonagh, Thomas; Keavey, Kenneth; Pons, Jean-Francois; Barker, Jonathan; Yau, Wei Tsung; Amouzegh, Patricia; Flegg, Adam; Hamelin, Estelle; Thomas, Russell J; Kates, Michael; Jones, Stephen; Navia, Manuel A; Saunders, Jeffrey O; DiStefano, Peter S; Curtis, Rory.

J Med Chem ; 48(25): 8045-54, 2005 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-16335928

13.

Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy.

Gopalakrishnapillai, Anilkumar; Kolb, E Anders; Dhanan, Priyanka; Mason, Robert W; Napper, Andrew; Barwe, Sonali P.

PLoS One ; 10(10): e0140564, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-26465153

14.

A sensitive luminescent assay for the histone methyltransferase NSD1 and other SAM-dependent enzymes.

Drake, Katherine M; Watson, Venita G; Kisielewski, Anne; Glynn, Rebecca; Napper, Andrew D.

Assay Drug Dev Technol ; 12(5): 258-71, 2014 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-24927133

15.

Controversies in ASSAY and drug development technologies: a focus on assessing irreproducibility.

Glickman, J Fraser; Lundbäck, Thomas; Napper, Andrew D; Niles, Walter D; Simeonov, Anton; Weaver, C David; Yin, Hongwei Holly; Zaman, Guido J R; Osada, Hiroyuki.

Assay Drug Dev Technol ; 12(8): 443-51, 2014 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-25383720

16.

An interview with Andrew D. Napper, Ph.D. Interview.

Napper, Andrew D.

Assay Drug Dev Technol ; 6(5): 611-20, 2008 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-19035845

17.

Drug Discovery and Development of Innovative Therapeutics--IBC's 13th Annual World Congress. Approaches to cancer therapy.

Napper, Andrew.

IDrugs ; 11(10): 705-9, 2008 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-18828066

18.

Biochemical-Based Assays for HTS --CHI's 14th Annual Conference.

Napper, Andrew.

IDrugs ; 11(7): 493-6, 2008 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-18600595

19.

Targeted drug discovery for pediatric leukemia.

Napper, Andrew D; Watson, Venita G.

Front Oncol ; 3: 170, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23847761

20.

Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technology.

Watson, Venita Gresham; Drake, Katherine M; Peng, Yu; Napper, Andrew D.

Assay Drug Dev Technol ; 11(4): 253-68, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23679849

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