Detalhe da pesquisa
1.
Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.
J Pharmacol Exp Ther
; 342(1): 205-13, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22518021
2.
The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry.
Mol Pharmacol
; 80(6): 1119-27, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21885621
3.
Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol Pharmacol
; 80(6): 1056-65, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21890748
4.
A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse.
Mol Pharmacol
; 77(4): 593-600, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20086035
5.
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity.
Mol Pharmacol
; 75(2): 318-23, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18987161
6.
Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.
J Pharmacol Exp Ther
; 331(2): 445-55, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19710369
7.
A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality.
Ann Emerg Med
; 54(3): 409-20, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19013687
8.
Hyper-phosphorylation of the adeno-associated virus Rep78 protein inhibits terminal repeat binding and helicase activity.
Biochim Biophys Acta
; 1576(3): 298-305, 2002 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12084576
9.
Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction.
Future Med Chem
; 4(2): 137-50, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22300094
10.
Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.
Neuropsychopharmacology
; 37(5): 1092-103, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21993206
11.
Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs.
Drug Alcohol Depend
; 119(3): 224-8, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21775073
12.
Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.
Neuropsychopharmacology
; 36(5): 1047-59, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21289605
13.
Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.
Drug Alcohol Depend
; 118(2-3): 158-65, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21481548
14.
Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats.
Drug Alcohol Depend
; 106(2-3): 219-29, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19800183
15.
Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng Des Sel
; 23(7): 537-47, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20436035
16.
Effects of cocaine esterase following its repeated administration with cocaine in mice.
Drug Alcohol Depend
; 101(3): 202-9, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217723
17.
Cocaine esterase: interactions with cocaine and immune responses in mice.
J Pharmacol Exp Ther
; 320(2): 926-33, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17114567
18.
Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase.
Mol Pharmacol
; 70(6): 1885-91, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16968810