Increasing coordination and responsivity of emotion-related brain regions with a heart rate variability biofeedback randomized trial.

Heart rate variability is a robust biomarker of emotional well-being, consistent with the shared brain networks regulating emotion regulation and heart rate. While high heart rate oscillatory activity clearly indicates healthy regulatory brain systems, can increasing this oscillatory activity also enhance brain function? To test this possibility, we randomly assigned 106 young adult participants to one of two 5-week interventions involving daily biofeedback that either increased heart rate oscillations (Osc+ condition) or had little effect on heart rate oscillations (Osc- condition) and examined effects on brain activity during rest and during regulating emotion. While there were no significant changes in the right amygdala-medial prefrontal cortex (MPFC) functional connectivity (our primary outcome), the Osc+ intervention increased left amygdala-MPFC functional connectivity and functional connectivity in emotion-related resting-state networks during rest. It also increased down-regulation of activity in somatosensory brain regions during an emotion regulation task. The Osc- intervention did not have these effects. In this healthy cohort, the two conditions did not differentially affect anxiety, depression, or mood. These findings indicate that modulating heart rate oscillatory activity changes emotion network coordination in the brain.

Energy-efficient multihypothesis activity-detection for health-monitoring applications.

Multi-hypothesis activity-detection using a wireless body area network is considered. A fusion center receives samples of biometric signals from heterogeneous sensors. Due to the different discrimination capabilities of each sensor, an optimized allocation of samples per sensor results in lower energy consumption. Optimal sample allocation is determined by minimizing the probability of misclassification given the current activity state of the user. For a particular scenario, optimal allocation can achieve the same accuracy (97%) as equal allocation across sensors with an energy savings of 26%. As the number of samples is an integer, further energy reduction is achieved by developing an approximation to the probability of misclassification which allows for a continuous-valued vector optimization. This alternate optimization yields approximately optimal allocations with significantly lower complexity, facilitating real-time implementation.