Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Chimeric antigen receptors of HBV envelope proteins inhibit hepatitis B surface antigen secretion.

Wang, Yang; Li, Qiqi; Li, Cheng; Wang, Cong; Wang, Shijie; Yuan, Wenjie; Yu, Demin; Zhang, Ke; Shi, Bisheng; Chen, Xiaomei; Liu, Tiantian; Yuan, Zhenghong; Tong, Shuping; Nassal, Michael; Wen, Yu-Mei; Wang, Yong-Xiang.

Gut ; 73(4): 668-681, 2024 Mar 07.

Artigo em Inglês | MEDLINE | ID: mdl-37973365

2.

Relaxing the restricted structural dynamics in the human hepatitis B virus RNA encapsidation signal enables replication initiation in vitro.

Dörnbrack, Katharina; Beck, Jürgen; Nassal, Michael.

PLoS Pathog ; 18(3): e1010362, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-35259189

3.

Conservation of the HBV RNA element epsilon in nackednaviruses reveals ancient origin of protein-primed reverse transcription.

Beck, Jürgen; Seitz, Stefan; Lauber, Chris; Nassal, Michael.

Proc Natl Acad Sci U S A ; 118(13)2021 03 30.

Artigo em Inglês | MEDLINE | ID: mdl-33753499

4.

A pocket-factor-triggered conformational switch in the hepatitis B virus capsid.

Lecoq, Lauriane; Wang, Shishan; Dujardin, Marie; Zimmermann, Peter; Schuster, Leonard; Fogeron, Marie-Laure; Briday, Mathilde; Schledorn, Maarten; Wiegand, Thomas; Cole, Laura; Montserret, Roland; Bressanelli, Stéphane; Meier, Beat H; Nassal, Michael; Böckmann, Anja.

Proc Natl Acad Sci U S A ; 118(17)2021 04 27.

Artigo em Inglês | MEDLINE | ID: mdl-33879615

5.

Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target.

Verrier, Eloi R; Ligat, Gaëtan; Heydmann, Laura; Doernbrack, Katharina; Miller, Julija; Maglott-Roth, Anne; Jühling, Frank; El Saghire, Houssein; Heuschkel, Margaux J; Fujiwara, Naoto; Hsieh, Sen-Yung; Hoshida, Yujin; Root, David E; Felli, Emanuele; Pessaux, Patrick; Mukherji, Atish; Mailly, Laurent; Schuster, Catherine; Brino, Laurent; Nassal, Michael; Baumert, Thomas F.

Gut ; 2022 Dec 09.

Artigo em Inglês | MEDLINE | ID: mdl-36591611

6.

Fast Magic-Angle-Spinning NMR Reveals the Evasive HepatitisâB Virus Capsid C-Terminal Domain.

Callon, Morgane; Malär, Alexander A; Lecoq, Lauriane; Dujardin, Marie; Fogeron, Marie-Laure; Wang, Shishan; Schledorn, Maarten; Bauer, Thomas; Nassal, Michael; Böckmann, Anja; Meier, Beat H.

Angew Chem Int Ed Engl ; 61(32): e202201083, 2022 08 08.

Artigo em Inglês | MEDLINE | ID: mdl-35653505

7.

Biomolecular solid-state NMR spectroscopy at 1200 MHz: the gain in resolution.

Callon, Morgane; Malär, Alexander A; Pfister, Sara; Rímal, Václav; Weber, Marco E; Wiegand, Thomas; Zehnder, Johannes; Chávez, Matías; Cadalbert, Riccardo; Deb, Rajdeep; Däpp, Alexander; Fogeron, Marie-Laure; Hunkeler, Andreas; Lecoq, Lauriane; Torosyan, Anahit; Zyla, Dawid; Glockshuber, Rudolf; Jonas, Stefanie; Nassal, Michael; Ernst, Matthias; Böckmann, Anja; Meier, Beat H.

J Biomol NMR ; 75(6-7): 255-272, 2021 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-34170475

8.

Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication.

Wang, Yong-Xiang; Niklasch, Matthias; Liu, Tiantian; Wang, Yang; Shi, Bisheng; Yuan, Wenjie; Baumert, Thomas F; Yuan, Zhenghong; Tong, Shuping; Nassal, Michael; Wen, Yu-Mei.

J Hepatol ; 72(5): 865-876, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-31863794

9.

Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure.

Heger-Stevic, Julia; Zimmermann, Peter; Lecoq, Lauriane; Böttcher, Bettina; Nassal, Michael.

PLoS Pathog ; 14(12): e1007488, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30566530

10.

Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load.

Schuch, Anita; Salimi Alizei, Elahe; Heim, Kathrin; Wieland, Dominik; Kiraithe, Michael Muthamia; Kemming, Janine; Llewellyn-Lacey, Sian; Sogukpinar, Özlem; Ni, Yi; Urban, Stephan; Zimmermann, Peter; Nassal, Michael; Emmerich, Florian; Price, David A; Bengsch, Bertram; Luxenburger, Hendrik; Neumann-Haefelin, Christoph; Hofmann, Maike; Thimme, Robert.

Gut ; 68(5): 905-915, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30622109

11.

How many steps to a feasible mouse model of hepatitis B virus infection?

Nassal, Michael.

Hepatology ; 77(4): 1090-1094, 2023 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-35871466

12.

A novel hepatitis B virus species discovered in capuchin monkeys sheds new light on the evolution of primate hepadnaviruses.

de Carvalho Dominguez Souza, Breno Frederico; König, Alexander; Rasche, Andrea; de Oliveira Carneiro, Ianei; Stephan, Nora; Corman, Victor Max; Roppert, Pia Luise; Goldmann, Nora; Kepper, Ramona; Müller, Simon Franz; Völker, Christof; de Souza, Alex Junior Souza; Gomes-Gouvêa, Michele Soares; Moreira-Soto, Andrés; Stöcker, Andreas; Nassal, Michael; Franke, Carlos Roberto; Rebello Pinho, João Renato; Soares, Manoel do Carmo Pereira; Geyer, Joachim; Lemey, Philippe; Drosten, Christian; Netto, Eduardo Martins; Glebe, Dieter; Drexler, Jan Felix.

J Hepatol ; 68(6): 1114-1122, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29428874

13.

Localizing Conformational Hinges by NMR: Where Do Hepatitis B Virus Core Proteins Adapt for Capsid Assembly?

Lecoq, Lauriane; Wang, Shishan; Wiegand, Thomas; Bressanelli, Stéphane; Nassal, Michael; Meier, Beat H; Böckmann, Anja.

Chemphyschem ; 19(11): 1336-1340, 2018 Jun 05.

Artigo em Inglês | MEDLINE | ID: mdl-29542854

14.

Structural Studies of Self-Assembled Subviral Particles: Combining Cell-Free Expression with 110âkHz MAS NMR Spectroscopy.

David, Guillaume; Fogeron, Marie-Laure; Schledorn, Maarten; Montserret, Roland; Haselmann, Uta; Penzel, Susanne; Badillo, Aurélie; Lecoq, Lauriane; André, Patrice; Nassal, Michael; Bartenschlager, Ralf; Meier, Beat H; Böckmann, Anja.

Angew Chem Int Ed Engl ; 57(17): 4787-4791, 2018 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-29457857

15.

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses.

Verrier, Eloi R; Colpitts, Che C; Bach, Charlotte; Heydmann, Laura; Weiss, Amélie; Renaud, Mickaël; Durand, Sarah C; Habersetzer, François; Durantel, David; Abou-Jaoudé, Georges; López Ledesma, Maria M; Felmlee, Daniel J; Soumillon, Magali; Croonenborghs, Tom; Pochet, Nathalie; Nassal, Michael; Schuster, Catherine; Brino, Laurent; Sureau, Camille; Zeisel, Mirjam B; Baumert, Thomas F.

Hepatology ; 63(1): 35-48, 2016 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-26224662

16.

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses.

Königer, Christian; Wingert, Ida; Marsmann, Moritz; Rösler, Christine; Beck, Jürgen; Nassal, Michael.

Proc Natl Acad Sci U S A ; 111(40): E4244-53, 2014 Oct 07.

Artigo em Inglês | MEDLINE | ID: mdl-25201958

17.

Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro.

Hoh, Alexander; Heeg, Maximilian; Ni, Yi; Schuch, Anita; Binder, Benedikt; Hennecke, Nadine; Blum, Hubert E; Nassal, Michael; Protzer, Ulrike; Hofmann, Maike; Urban, Stephan; Thimme, Robert.

J Virol ; 89(14): 7433-8, 2015 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-25972537

18.

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B.

Nassal, Michael.

Gut ; 64(12): 1972-84, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26048673

19.

Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes.

Ni, Yi; Lempp, Florian A; Mehrle, Stefan; Nkongolo, Shirin; Kaufman, Christina; Fälth, Maria; Stindt, Jan; Königer, Christian; Nassal, Michael; Kubitz, Ralf; Sültmann, Holger; Urban, Stephan.

Gastroenterology ; 146(4): 1070-83, 2014 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-24361467

20.

Chronic hepatitis B: divide and conquer?

Nassal, Michael.

Gut ; 67(3): 400-402, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-28706078

BVS Doenças Infecciosas e Parasitárias

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Chimeric antigen receptors of HBV envelope proteins inhibit hepatitis B surface antigen secretion.

Relaxing the restricted structural dynamics in the human hepatitis B virus RNA encapsidation signal enables replication initiation in vitro.

Conservation of the HBV RNA element epsilon in nackednaviruses reveals ancient origin of protein-primed reverse transcription.

A pocket-factor-triggered conformational switch in the hepatitis B virus capsid.

Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target.

Fast Magic-Angle-Spinning NMR Reveals the Evasive HepatitisâB Virus Capsid C-Terminal Domain.

Biomolecular solid-state NMR spectroscopy at 1200 MHz: the gain in resolution.

Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication.

Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure.

Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load.

How many steps to a feasible mouse model of hepatitis B virus infection?

A novel hepatitis B virus species discovered in capuchin monkeys sheds new light on the evolution of primate hepadnaviruses.

Localizing Conformational Hinges by NMR: Where Do Hepatitis B Virus Core Proteins Adapt for Capsid Assembly?

Structural Studies of Self-Assembled Subviral Particles: Combining Cell-Free Expression with 110âkHz MAS NMR Spectroscopy.

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses.

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses.

Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro.

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B.

Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes.

Chronic hepatitis B: divide and conquer?