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1.
J Geriatr Psychiatry Neurol ; 36(3): 215-224, 2023 05.
Artigo em Inglês | MEDLINE | ID: mdl-35977708

RESUMO

PURPOSE: The purpose of this study was to examine the relationship between psychological factors (depression, anxiety, and catastrophizing) and fear of falling avoidance behavior (FFAB) among individuals with Parkinson's disease (PD). METHODS: A secondary analysis of cross-sectional data from 59 individuals with PD using hierarchical multiple regression. RESULTS: Disease severity (Movement Disorder Society - Unified PD Rating Scale) and catastrophizing (Consequences of Falling Questionnaire (CoF)) explained approximately 48.2% of the variance in the FFAB Questionnaire scores (P < .001). Catastrophizing was the only significant psychological variable (P < .001). The damage to identity subscale of the CoF was significant in the final model (P < .001). CONCLUSIONS: Catastrophizing about the consequences of falls explained the largest portion of variability in FFAB after controlling for disease severity. Catastrophizing about the immediate consequences of falling may play a prominent role in FFAB and may be a potential treatment target for mitigating FFAB.


Assuntos
Medo , Doença de Parkinson , Humanos , Medo/psicologia , Doença de Parkinson/complicações , Doença de Parkinson/psicologia , Depressão , Aprendizagem da Esquiva , Estudos Transversais , Ansiedade/psicologia , Catastrofização/psicologia
2.
Support Care Cancer ; 31(7): 406, 2023 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-37341787

RESUMO

PURPOSE: To evaluate the risk of sarcopenia on the length of hospital stay and deaths in preoperative cancer patients as well its relation to physical and functional capacity. METHODS: Preoperative patients admitted to the Cancer Hospital of Mato Grosso comprised the sample. Sociodemographic data, lifestyle data, and a questionnaire for sarcopenia screening were collected. Subsequently, total body mass, height, muscle strength, muscle mass, and physical performance were evaluated. The primary, secondary and tertiary outcomes were sarcopenia, length of stay and death, respectively. The data were tabulated and analyzed using the statistical software SPSS (25.0). The significance level was 5%. RESULTS: We observed 12 (7.4%) patients with low muscle strength, 20 (12.3%) patients with low muscle mass, 11 (6.8%) patients with low physical performance, and 18 (11.1%) patients with scores for possible sarcopenia. When the risk of sarcopenia was observed, 44 (27.2%) patients had at least one risk related to muscle disorder. When analyzing the prevalence and association of sarcopenia with sociodemographic variables, we observed that education level was associated with sarcopenia (p = 0.031). In addition, there was an association between preoperative sarcopenia and postoperative death (p = 0.006). Finally, there were important correlations between muscle strength and physical performance (p < 0.05), between muscle strength and the sarcopenia questionnaire (p < 0.001), and between physical performance and the sarcopenia questionnaire (p < 0.05). CONCLUSION: The results suggest the need for counseling and the need to evaluate patients for risk of sarcopenia, since early intervention, such as dietary supplementation and physical exercise, may favor a better postoperative prognosis, possibly corresponding to shorter hospital stays and longer survival and quality of life for patients, especially those who will undergo surgical procedures.


Assuntos
Sarcopenia , Humanos , Sarcopenia/etiologia , Sarcopenia/complicações , Qualidade de Vida , Força Muscular/fisiologia , Prognóstico , Estilo de Vida , Músculo Esquelético/fisiologia
3.
Scand J Med Sci Sports ; 31(3): 720-732, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33185897

RESUMO

To evaluate the effect of combined resistance and aerobic training (RT+AT) on regional bone mineral density (BMD) and physical performance in people living with HIV (PLWH). Forty PLWH (20 men and 20 women) were randomized into RT+AT group (n = 20; age = 38.3 ± 4.9) or non-exercise control group (n = 20; age = 37.9 ± 5.1). The RT+AT group was required to perform a nonlinear periodized resistance training program targeting large muscle groups followed by 20 min aerobic exercise at 65-80% of maximal heart rate. Participants in RT+AT performed three supervised sessions per week for 6-months, whereas participants in the control group were instructed to continue with their current lifestyle habits. The primary outcome was bone mineral density (lumbar spine (L2-L4), femoral neck, and distal 1/3 radius). Secondary outcomes included physical function, anthropometry, inflammatory markers, and growth factors. The RT+AT group demonstrated a significant increase in BMD at follow-up for the Lumbar spine (L2-L4), femoral neck, and 1/3 radius (all, P < .05), and There were no gender differences in the training response between men and women for any of the BMD regions. Similar findings were also observed for lean body mass, IGF1and Adiponectin (P < .001). We observed a decrease in percent body fat, fat mass, IL-6, TNF-α, and myostatin in the RT+AT group (P < .001). Finally, there was a significant increase in handgrip strength and gait speed for both women and men in the RT+AT group (P < .001). A combination of resistance and aerobic training appears to be a feasible and effective means for counteracting bone loss and improving various inflammatory markers, physical function, and growth hormones in PLWH.


Assuntos
Densidade Óssea/fisiologia , Infecções por HIV/fisiopatologia , Condicionamento Físico Humano/métodos , Treinamento Resistido , Adiponectina/sangue , Adulto , Biomarcadores/sangue , Índice de Massa Corporal , Feminino , Fibronectinas/sangue , Força da Mão , Humanos , Fator de Crescimento Insulin-Like I/metabolismo , Interleucina-6/sangue , Masculino , Pessoa de Meia-Idade , Miostatina/sangue , Desempenho Físico Funcional , Método Simples-Cego , Fator de Necrose Tumoral alfa/sangue , Velocidade de Caminhada
4.
Int J Environ Health Res ; 31(2): 121-131, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31240953

RESUMO

Green exercise is beneficial to emotional and physiological measures, however, the US has large desert areas. We aimed to determine if exercise in a desert (brown) environment extends similar benefits to green. Participants (N = 10) completed baseline measures (PRE), 30-min seated rest (SIT), and 30-min self-paced walking (WALK) in: indoor, outdoor urban, green, and two brown environments. Heart rate (HR), blood pressure (BP), and measures of stress, comfort, and calm were obtained. After SIT, HR was elevated in urban vs green (p = 0.05). Systolic BP was lower after SIT compared to PRE and WALK (p = 0.05). Brown and green returned greater comfort and calm scores (p = 0.001). Stress was lower following WALK than PRE and SIT (p < 0.01). Comfort and calm were greatest in natural environments, and exercise significantly reduced perceived stress. Taken together, these data provide evidence that exercise in a desert environment is just a beneficial as the exercise performed in a green environment. Abbreviations: ANCOVA: analysis of covariance; ANOVA: analysis of variance; AU: arbitrary units; BP: blood pressure; BSL: below sea level; DBP: diastolic blood pressure; HR: heart rate; PRE: baseline measurement; PS: perceived stress; SBP: systolic blood pressure; SIT: measurement following 30-min seated rest; WALK: measurement following 30-min self-paced walking.


Assuntos
Pressão Sanguínea/fisiologia , Clima Desértico , Exercício Físico/fisiologia , Frequência Cardíaca/fisiologia , Estresse Fisiológico/fisiologia , Adulto , Cidades , Teste de Esforço , Feminino , Voluntários Saudáveis , Humanos , Masculino , Descanso/fisiologia , Estados Unidos , Caminhada/fisiologia
5.
J Neurol Phys Ther ; 43(1): 12-25, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30531382

RESUMO

BACKGROUND AND PURPOSE: The feasibility, safety, and efficacy of a high-intensity multimodal exercise program (aerobic, strengthening, and balance training) have not been well vetted in persons with Parkinson disease (PD). Thus, the primary aim was to determine whether a high-intensity multimodal exercise boot camp (HIBC) was both feasible and safe in persons with PD. The secondary aim was to determine whether the program would produce greater benefit than a usual care, low-intensity exercise program (UC). An exploratory aim was to determine whether these programs affected putative disease-modifying mechanisms. METHODS: Twenty-seven participants (19 men and 8 women) were randomized into 8 weeks of either the HIBC or UC supervised by physical therapists. For feasibility, participation, and meeting, Centers for Disease Control and Prevention (CDC) exercise guidelines were assessed. For safety, adverse events were monitored. For efficacy, the following outcome domains were assessed before and after participation: balance, motor activity, endurance and fatigue, strength, mental health, and quality of life. For disease-modifying mechanisms, circulating brain-derived neurotrophic factor (BDNF) and its genotype, superoxide dismutase, and cytokines (tumor necrosis factor-α, interleukin-6, and interleukin-10) were monitored. RESULTS: The HIBC was better at attaining CDC guidelines (P = 0.013) and spent more minutes in higher-intensity exercise per week (P < 0.001). There were no differences in adverse events (P = 0.419). The HIBC experienced significant improvements in 7/31 outcomes versus 3/31 in the UC arm. BDNF improved significantly for both groups from pre- to posttests (Ps ≤ 0.041) and an improved anti-inflammatory was observed for both groups. DISCUSSION AND CONCLUSIONS: A high-intensity multimodal exercise boot camp was feasible and safe in persons with PD. Compared with usual care, there were no differences in adverse events. Moreover, the high-intensity multimodal exercise program produced more improvement across more domains than usual care. Our results also suggest a possible link between improvement in outcomes and an improved anti-inflammatory milieu.Video Abstract available for more insights from the authors (see Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A244).


Assuntos
Terapia por Exercício/métodos , Avaliação de Processos e Resultados em Cuidados de Saúde , Doença de Parkinson/terapia , Idoso , Fator Neurotrófico Derivado do Encéfalo/genética , Citocinas/sangue , Terapia por Exercício/efeitos adversos , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/sangue , Doença de Parkinson/genética
6.
Int J Sports Med ; 40(8): 498-502, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31288288

RESUMO

Footpod monitors are wearable devices attaching to the shoe with the ability to sense oscillations in leg movement; however, few studies provide reliability. The purpose was to provide reliability data for outdoor tasks as measured by the Stryd Power Meter, which is a footpod monitor. Young healthy individuals (N=20, male n=12, female n=8) completed two 5-min self-paced walks along a trail, and two 5-min trail runs. Reliability of the tasks was determined using Coefficient of Variation (CV), Intraclass Correlation (ICC), and 95% confidence intervals (CI). Measures during trail running that returned a CV less than 10%, met the ICC threshold of 0.70, and displayed good to excellent 95% CI included pace, average elapsed power, average elapsed form power, average elapsed leg spring, and vertical oscillation. The only variable during walking to meet these criteria was maximal power (CV=4.02%, ICC=0.968, CI=0.902, 0.989). Running tasks completed on a trail generally return more consistent measures for variables that can be obtained from the Stryd footpod device than walking tasks.


Assuntos
Monitores de Aptidão Física/normas , Corrida/fisiologia , Caminhada/fisiologia , Desenho de Equipamento , Feminino , Humanos , Masculino , Reprodutibilidade dos Testes , Análise e Desempenho de Tarefas , Adulto Jovem
7.
J Sports Sci ; 37(6): 685-691, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30326783

RESUMO

Performer autonomy has been shown to contribute to effective motor performance and learning. Autonomy support is therefore a key factor in the OPTIMAL theory of motor learning (Wulf, G., & Lewthwaite, 2016). The purpose of the present study was to examine whether supporting individuals' need for autonomy by giving them choices would increase movement efficiency. Such a finding would be consistent with the OPTIMAL theory prediction that autonomy facilitates the coupling of goals and actions. Participants (N = 32) were asked to run at a submaximal intensity (65% of VO2 max) for 20 minutes. Before the run, participants in a choice group were able to choose 5 of 10 photos as well as the order in which they would be shown to them on a computer screen during the run. Control group participants were shown the same photos, in the same order, chosen by their counterparts in the choice group. Throughout the run, oxygen consumption and heart rate were significantly lower in the choice group than the control group. Thus, providing autonomy support resulted in enhanced running efficiency. The present findings are in line with the notion that autonomy facilitates goal-action coupling.


Assuntos
Autonomia Pessoal , Corrida/fisiologia , Feminino , Frequência Cardíaca , Humanos , Aprendizagem , Masculino , Destreza Motora/fisiologia , Consumo de Oxigênio , Esforço Físico , Adulto Jovem
8.
J Strength Cond Res ; 33(4): 1146-1155, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29219895

RESUMO

Ghayomzadeh, M, SeyedAlinaghi, S, Shamsi, MM, Rezaei, S, Earnest, CP, Akbarnejad, S, Taj, L, Mohraz, M, Navalta, JW, Ghasemi, P, and Voltarelli, FA. Effect of 8 weeks of hospital-based resistance raining program on TCD4+ cell count and anthropometric characteristic of patients with HIV in Tehran, Iran: A randomized controlled trial. J Strength Cond Res 33(4): 1146-1155, 2019-We examined the effects of an 8-W circuit resistance training (RES) program using elastic bands and body weight on TCD4+ cell counts and anthropometry in patients with HIV. Patients (N = 21) receiving antiretroviral therapy were randomly assigned to resistance training (RES; n = 14) or control (CON; n = 7) groups. RES (3/W) consisted of training with elastic bands and bodyweight training focusing on major muscle groups. CON received standard care. Statistical analyses were performed using general linear models adjusted for age, sex, length of infection, and respective baseline measures. The primary outcome was TCD4+, and secondary outcomes were anthropometry indices. Tertiary assessments explored Pearson correlations surrounding the relationship between changes in anthropometry and TCD4+. We observed significant increases in TCD4+ count accompanying RES training (105.50 cells·mm, 95% confidence interval [CI], 47.42-163.59), whereas CON significantly decreased (-41.01 cells·mm, 95% CI, -126.78 to 44.76). Significant between-group differences were noted (p < 0.02; n = 0.42). We also observed significant reductions in fat mass for RES (1.18 kg, 95% CI = 1.80 to -0.56) vs. increased fat mass for CON (1.21 kg, 95% CI, 0.31 to 2.11). Significant between-group differences were noted (p = 0.001, n = 0.64). Similar effects were noted for lean body mass. No significant changes were observed for body mass. Significant correlations were observed for fat mass (r = -0.699, p = 0.001) and lean mass (r = 0.553, p = 0.017), but not body mass (r = -0.390, p = 0.109) vs. changes in TCD4+. Our results suggest that the RES program used in this study is effective for improving TCD4+ status and body composition in patients with HIV.


Assuntos
Linfócitos T CD4-Positivos , Terapia por Exercício/métodos , Infecções por HIV/sangue , Infecções por HIV/terapia , Treinamento Resistido , Adiposidade , Adulto , Antirretrovirais/uso terapêutico , Peso Corporal , Contagem de Linfócito CD4 , Feminino , Infecções por HIV/tratamento farmacológico , Humanos , Irã (Geográfico) , Masculino , Pessoa de Meia-Idade , Músculo Esquelético , Adulto Jovem
9.
J Sports Sci Med ; 18(4): 772-779, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31827362

RESUMO

A common practice among bodybuilders is the use of carbohydrate loading to improve physical appearance during competition, while limited documented data is available about this issue. The aim of the present study was to evaluate muscle thickness, mood states, gastrointestinal symptoms and subjective silhouette assessment following carbohydrate loading in bodybuilders. Twenty-four male bodybuilders were evaluated at the weighing period following three days of carbohydrate depletion (M1), and 24h of carbohydrate loading leading up to the competition (M2), stratified into: no carbohydrate load (NC, n = 9) and carbohydrate loading (CL, n =1 5). The silhouette scale, Brunel mood scale (BRUMS), muscle thickness (ultrasound), circumferences, and gastrointestinal symptoms (GIS) were evaluated at M1 and M2. The NC displayed no differences in muscle thickness and circumferences between M1 and M2. Body mass, muscle thickness (elbow flexors, a combination of biceps brachii/ brachialis muscle, and triceps brachii) and circumferences (chest, hip, thigh, arm, calves, and forearm) increased significantly (p < 0.05) in the CL at M2. There was a significant increase in photo silhouette scores (p < 0.05) in the CL at M2. There was no significant difference in mood states between groups or time. The most reported GIS was constipation: 7/9 (NC) and 9/15 (CL) during M1 and 6/9 (NC), and 5/15 (CL) at M2 with symptoms described as 'moderate' or 'severe'. Diarrhea was reported by 7/15 CL (4/15 as severe). These data suggest that carbohydrate loading may contribute to an acute increase in muscle volume and physical appearance, however, it needs to be better planned to minimize gastrointestinal symptoms in bodybuilders.


Assuntos
Afeto , Constipação Intestinal/etiologia , Diarreia/etiologia , Dieta da Carga de Carboidratos/efeitos adversos , Músculo Esquelético/anatomia & histologia , Levantamento de Peso/fisiologia , Levantamento de Peso/psicologia , Adulto , Índice de Massa Corporal , Comportamento Competitivo/fisiologia , Humanos , Masculino , Músculo Esquelético/diagnóstico por imagem , Fotografação , Ultrassonografia , Adulto Jovem
10.
Eur J Nutr ; 57(3): 1083-1096, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28236109

RESUMO

PURPOSE: Although there is limited evidence regarding the pathophysiological effects of a high-protein diet (HD), it is believed that this type of diet could overload the body and cause damage to the organs directly involved with protein metabolism and excretion. The aim of this study was to verify the effects of HD on biochemical and morphological parameters of rats that completed a resistance training protocol (RT; aquatic jump) for 8 weeks. METHODS: Thirty-two adult male Wistar rats were divided into four groups (n = 8 for each group): sedentary normal protein diet (SN-14%), sedentary high-protein diet (SH-35%), trained normal protein diet (TN-14%), and trained high-protein diet (TH-35%). Biochemical, tissue, and morphological measurements were made. RESULTS: Kidney (1.91 ± 0.34) and liver weights (12.88 ± 1.42) were higher in the SH. Soleus muscle weight was higher in the SH (0.22 ± 0.03) when compared to all groups. Blood glucose (123.2 ± 1.8), triglycerides (128.5 ± 44.0), and HDL cholesterol levels (65.7 ± 20.9) were also higher in the SH compared with the other experimental groups. Exercise reduced urea levels in the trained groups TN and TH (31.0 ± 4.1 and 36.8 ± 6.6), respectively. Creatinine levels were lower in TH and SH groups (0.68 ± 0.12; 0.54 ± 0.19), respectively. HD negatively altered renal morphology in SH, but when associated with RT, the apparent damage was partially reversed. In addition, the aquatic jump protocol reversed the damage to the gastrocnemius muscle caused by the HD. CONCLUSIONS: A high-protein diet promoted negative metabolic and morphological changes, while RT was effective in reversing these deleterious effects.


Assuntos
Dieta Rica em Proteínas , Hiperglicemia/prevenção & controle , Hipertrigliceridemia/prevenção & controle , Hipertrofia/prevenção & controle , Desenvolvimento Muscular , Músculo Esquelético/crescimento & desenvolvimento , Treinamento Resistido , Animais , Biomarcadores/sangue , Glicemia/análise , HDL-Colesterol/sangue , Creatinina/sangue , Dieta Rica em Proteínas/efeitos adversos , Hiperglicemia/sangue , Hiperglicemia/etiologia , Hiperglicemia/patologia , Hipertrigliceridemia/sangue , Hipertrigliceridemia/etiologia , Hipertrigliceridemia/patologia , Hipertrofia/sangue , Hipertrofia/etiologia , Hipertrofia/patologia , Rim/citologia , Rim/crescimento & desenvolvimento , Rim/patologia , Fígado/citologia , Fígado/crescimento & desenvolvimento , Fígado/patologia , Masculino , Músculo Esquelético/citologia , Músculo Esquelético/patologia , Tamanho do Órgão , Distribuição Aleatória , Ratos Wistar , Treinamento Resistido/efeitos adversos , Triglicerídeos/sangue , Ureia/sangue
11.
J Neurol Phys Ther ; 42(2): 61-71, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-29547479

RESUMO

BACKGROUND AND PURPOSE: Because falls can have deleterious consequences, it is important to understand the influence of fatigue and medications on balance in persons with Parkinson disease (PD). Thus, the purpose of this study was to investigate the effects of fatigue on balance in individuals with PD. Because brain-derived neurotrophic factor (BDNF) has been shown to be related to motor performance, we also explored its role. METHODS: A total of 27 individuals (age = 65.4 ± 8.1 years; males = 14, females = 13) with neurologist-diagnosed PD with 13 genotyped for BDNF as Val66Val, 11 as Val66Met, 2 as Met66Met (1 refused). Participants were tested both on and off medication, 1 week apart. On both days, they completed a pre- and posttest separated by a fatiguing condition. Factorial analyses of variance were performed for the following balance domains: (1) anticipatory postural responses; (2) adaptive postural responses; (3) dynamic balance; (4) sensory orientation; and (5) gait kinematics. For BDNF, t-tests were conducted comparing genotype for the pre-post difference scores in both the on and off medication states. RESULTS: There were no interactions between time (pre- and postintervention) and medication for any of the domains (Ps ≥ 0.187). Participants with BDNF Met alleles were not significantly different from Val66Val participants in balance (Ps ≥ 0.111) and response to a fatiguing condition (Ps ≥ 0.070). DISCUSSION AND CONCLUSIONS: Fatigue does not appear to have a detrimental effect on balance, and there was not a differential effect of medication in individuals with PD. These results also indicate that participants with a BDNF Met allele did not have a greater decay in function after a fatiguing condition.Video Abstract available for more insights from the authors (see Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A196).


Assuntos
Antiparkinsonianos/uso terapêutico , Fator Neurotrófico Derivado do Encéfalo/genética , Fadiga/fisiopatologia , Doença de Parkinson/fisiopatologia , Equilíbrio Postural/fisiologia , Idoso , Fenômenos Biomecânicos/fisiologia , Terapia por Exercício/métodos , Feminino , Marcha/fisiologia , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/tratamento farmacológico , Doença de Parkinson/genética , Equilíbrio Postural/efeitos dos fármacos , Reprodutibilidade dos Testes
12.
Int J Sports Med ; 38(4): 263-269, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28219103

RESUMO

Cardiotonic drugs and exercise training promote cardiac inotropic effects, which may affect training-induced cardiac adaptations. This study investigated the effects of long-term administration of digoxin on heart structure and function, and physical performance of rats submitted to high-intensity interval training (HIIT). Male Wistar rats, 60 days old, were divided into control (C), digoxin (DIGO), trained (T), and trained with digoxin (TDIGO). Digoxin was administered by gavage (30 µg/kg/day) for 75 days. The HIIT program consisted of treadmill running 60 min/day (8 min at 80% of the maximum speed (MS) and 2 min at 20% of the MS), 5 days per week during 60 days. The main cardiac parameters were evaluated by echocardiograph and cardiomyocyte area was determined by histology. There were no group x time effects of digoxin, HIIT or interactions (digoxin and HIIT) on functional echocardiographic parameters (heart rate; ejection fraction) or in the maximum exercise test. There was a group x time interaction, as evidenced by observed cardiac hypertrophy in the TDIGO group evaluated by ratio of left ventricle weight to body weight (p<0.002) and cardiomyocyte area (p<0.000002). Long-term administration of digoxin promoted cardiac hypertrophy without affecting cardiac function and physical performance in rats submitted to HIIT.


Assuntos
Cardiomegalia/induzido quimicamente , Digoxina/efeitos adversos , Coração/efeitos dos fármacos , Condicionamento Físico Animal , Animais , Ecocardiografia , Teste de Esforço , Frequência Cardíaca , Treinamento Intervalado de Alta Intensidade , Masculino , Distribuição Aleatória , Ratos , Ratos Wistar
13.
Int J Sports Med ; 38(4): 307-313, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28219105

RESUMO

The aim of this study was to investigate the effects of different resistance training (RT) volumes on MMP activity in skeletal muscle, visceral adipose tissue and circulation. 21 Wistar rats were randomly divided into 3 groups (n=7 per group): sedentary control (SC); RT with 4 ladder climbs (RT-4; 50, 75, 90 and 100% of their maximal carrying capacity) and RT with 8 ladder climbs (RT-8 with 2 sets for each load). The 8-week RT consisted of climbing a 1.1-m vertical ladder with weights secured to the animals' tails. MMP-2 and -9 activity were analyzed by zymography. RT-8 displayed higher active MMP-2 activity as compared with SC and RT-4 in skeletal muscle (p<0.05). There was no significant difference between groups for pro and intermediate-MMP-2 activity in visceral adipose tissue, while RT-8 presented lower active MMP-2 activity as compared with SC (p<0.05). Plasma pro and active MMP-2 and MMP-9 activity was lower in RT-8 as compared with RT-4 (p<0.05). These results suggest that higher volume RT up-regulates MMP-2 activity in skeletal muscle, while down-regulating MMP-2 in visceral adipose tissue. Moreover, it induces a decrease of MMP-2, 9 activity in circulation. Different tissue and circulatory MMP responses to RT may result in specific remodeling.


Assuntos
Tecido Adiposo/fisiologia , Metaloproteinase 2 da Matriz/sangue , Metaloproteinase 9 da Matriz/sangue , Músculo Esquelético/fisiologia , Condicionamento Físico Animal , Treinamento Resistido , Animais , Masculino , Metaloproteinase 2 da Matriz/fisiologia , Metaloproteinase 9 da Matriz/fisiologia , Distribuição Aleatória , Ratos , Ratos Wistar
15.
Aging Clin Exp Res ; 27(6): 791-7, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25813986

RESUMO

BACKGROUND: Obesity, defined by an excess amount of body fat or a percent body fat higher than 30 % for women is a complex chronic disorder with multifactorial etiology and is accompanied by chronic low-grade inflammation, which results in elevated pro-inflammatory cytokines. AIMS: The aim of this study was to compare muscle strength between high and low pro-inflammatory status in obese elderly women and to verify the relationship of IL-6 with muscle strength and fat-free mass. METHODS: Eighty-nine elderly women (age 69.47 ± 6.07 years; body mass 64.70 ± 12.04 kg; height 1.52 ± 0.06 m; body mass index 27.78 ± 4.75 kg/m(2)) were divided into two groups: high and low inflammatory status for IL-6. Lower limb muscle strength was tested using bilateral leg extension with the ten repetitions maximum test, IL-6 was measured by ELISA and body composition by dual-energy X-ray absorptiometry. RESULTS: Women classified from the high pro-inflammatory status presented lower relative muscle strength (P = 0.056) when compared with the low inflammatory status group, with no differences for absolute muscle strength (P = 0.18). There was a significant negative correlation of IL-6 with relative muscle strength (P = 0.03, R = -0.22) and a considerable trend toward significance (P = 0.06, R = -0.19) and negative association with fat-free mass (P = 0.84, R = -0.02). CONCLUSIONS: This study provides insights that a high pro-inflammatory status in sedentary obese elderly women might impair muscle strength and negatively affect fat-free mass. Thus, elderly women classified with high pro-inflammatory status for IL-6 should receive further health care attention to prevent this deleterious condition.


Assuntos
Envelhecimento/fisiologia , Composição Corporal/imunologia , Inflamação , Interleucina-6/imunologia , Obesidade , Absorciometria de Fóton/métodos , Idoso , Índice de Massa Corporal , Doença Crônica , Comorbidade , Feminino , Humanos , Inflamação/sangue , Inflamação/fisiopatologia , Extremidade Inferior/fisiopatologia , Pessoa de Meia-Idade , Força Muscular/fisiologia , Obesidade/complicações , Obesidade/diagnóstico , Obesidade/imunologia , Obesidade/fisiopatologia , Estatística como Assunto
16.
Immunol Invest ; 43(2): 113-22, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24206426

RESUMO

Although aging compromises the functionality of macrophages (MΦ) and lymphocytes (LY), and dietary restriction (DR) and exercise partially counterbalance immunosenescence, it is unknown what effects of both strategies have on the functionality of these immune cells. Rats were randomly distributed into adult control (AD), older group (OLD), older submitted to 50% of DR (DR) and older submitted to swimming (EX) (n = 10 in each group). The function of immune cells (proliferative index, phagocytic capacity and H2O2 production), the weight and protein content of lymphoid organs (thymus and spleen), plasma glutamine concentration, interleukins (IL-1, IL-2, IL-6) and, immunoglobulins (IgA and IgG) were analysed. There was an increase of 74% in body weight in aged animals as compared with the AD group, while body weight reduced 19% in the DR as compared with the OLD group. Swimming training stimulated MΦ phagocytosis, while the EX group presented a decrease of the proliferative capacity of LY from the mesenteric lymph nodes (44% and 62%, respectively), when stimulated with ConA and LPS as compared with the old rats. These data demonstrated that DR and exercise affects differentially MΦ and LY function.


Assuntos
Envelhecimento/imunologia , Dieta/estatística & dados numéricos , Linfócitos/imunologia , Macrófagos/imunologia , Natação/estatística & dados numéricos , Animais , Peso Corporal , Proliferação de Células , Células Cultivadas , Citocinas/sangue , Peróxido de Hidrogênio/metabolismo , Imunoglobulina A/sangue , Imunoglobulina G/sangue , Masculino , Fagocitose , Ratos , Ratos Wistar
17.
J Sports Sci ; 32(8): 785-92, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24289219

RESUMO

The practice of exercise has shown to be beneficial to quality of life of individuals with HIV/AIDS. Thus, the present study analysed the effects of a combined exercise training in persons living with HIV/AIDS. Ten participants participated in the present study. The following variables were analysed: viral load and cell counts for TCD4+/TCD8; maximal oxygen consumption (VO2max); total mass, absolute fat mass, relative fat mass, absolute lean mass, relative lean mass and body mass index; fasting glycaemia, fasting insulinaemia, homeostatic model assessment (HOMA) index (insulin resistance - homeostatic model assessment (IR-HOMA)); total cholesterol, triglycerides, high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), low-density lipoprotein (LDL); superoxide dismutase, catalase, glutathione peroxidase activities; thiobarbituric acid reactive substances. The combined exercise training consisted of resistance exercises plus aerobic training (60 min · session(-1), three times per week, during 20 weeks). The number of TCD4+ cells, absolute lean mass and relative lean mass, muscle strength for the 45° leg press, seated row and triceps extension, HDL-c levels as well as VO2max increased post-training. The activity of superoxide dismutase, catalase, glutathione peroxidase enzymes and thiobarbituric acid reactive substances levels were diminished post-training. Finally, it can be concluded that combined exercise training is able to change positively several variables related to health of individuals with HIV/AIDS, mainly the immune system as well as antioxidant mechanisms re-establishment.


Assuntos
Síndrome da Imunodeficiência Adquirida/fisiopatologia , Síndrome da Imunodeficiência Adquirida/terapia , Terapia por Exercício , Síndrome da Imunodeficiência Adquirida/virologia , Adiposidade/fisiologia , Adulto , Glicemia/metabolismo , Índice de Massa Corporal , Relação CD4-CD8 , Catalase/sangue , HDL-Colesterol/sangue , Glutationa Peroxidase/sangue , Hemostasia , Humanos , Insulina/sangue , Pessoa de Meia-Idade , Força Muscular , Consumo de Oxigênio , Superóxido Dismutase/sangue , Tiobarbitúricos/sangue , Carga Viral
18.
J Bodyw Mov Ther ; 39: 116-121, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38876614

RESUMO

Adverse side effects from pharmacological treatments cause people with migraine to delay or avoid taking medication. Exercise is effective, but the effect of environment is unknown. The purpose was to determine if a natural environment affects monthly migraine load. Sedentary individuals (8 female, 1 non-binary) who experienced migraines participated. Participants completed one month of exercise (3 x week, 30-min, 60-70% estimated HRmax) indoors as well as in a natural outdoor environment in a randomized counterbalanced order. Migraine load was determined using the Headache Impact Test (HIT-6) and Migraine Disability Assessment (MIDAS) at the beginning and end of each month. Data were analyzed using repeated measures ANOVA. No interactions were evident for HIT-6 (p = 0.80), MIDAS (p = 0.72), migraine days (p = 0.508), or pain intensity (p = 0.66). No main effects were noted. Compliance was greater in the outdoor environment, with more exercise sessions completed in nature (Indoor = 72%, Outdoor = 90%, p < 0.001). Exercise environment did not impact MIDAS or HIT-6 questionnaire results, number of migraine days, or pain intensity. While there was no reduction in migraine load, it is possible that other health benefits were experienced due to greater compliance in a natural environment.


Assuntos
Estudos Cross-Over , Terapia por Exercício , Transtornos de Enxaqueca , Cooperação do Paciente , Humanos , Transtornos de Enxaqueca/terapia , Feminino , Masculino , Adulto , Terapia por Exercício/métodos , Projetos Piloto , Pessoa de Meia-Idade , Meio Ambiente , Doença Crônica , Medição da Dor
19.
Clin Nurs Res ; 33(1): 34-39, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-37649306

RESUMO

The aims of this study were to (1) explore this sample's pre- and post-intervention dietary intake, specifically the macro- and micronutrients, and their eating habits related to location of consumption and use of electronic devices, and (2) compare this sample's nutritional measures to the current Dietary Guidelines 2020 to 2025. Twenty-eight participants were included in the secondary data analysis. Participants reported a total of 822 items consumed during this study. Most items were consumed at home (n = 629, 76.5%). We found significant differences in the intake of energy, protein, total fat, carbohydrates, total vegetables, total grains, and total meat in different locations. For most of these measures, consumption at home and/or restaurants resulted in a greater magnitude of consumption than at other locations (e.g., car, daycare). Participants reported consuming most of their energy and nutrients while either using electronic devices alone (n = 365, 44.4%) or using no devices (n = 346, 42.1%). Significant differences were found among three measures including energy, total fat, and total fiber. The majority of the macronutrients (total fiber, fruits, vegetables, meat, and dairy) consumed by our sample were under the threshold recommended in the 2020 to 2025 Dietary Guidelines.


Assuntos
Gorduras na Dieta , Ingestão de Energia , Humanos , Ingestão de Alimentos , Verduras , Estudantes , Comportamento Alimentar
20.
BMC Cardiovasc Disord ; 13: 105, 2013 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-24252583

RESUMO

BACKGROUND: The aim of the present study was to evaluate the acute effects of resistance exercise (RE) leading to failure and RE that was not to failure on 24 h blood pressure (BP) and heart rate variability (HRV) in sedentary normotensive adult women. METHODS: Ten women (33.2 ± 5.8 years; 159.3 ± 9.4 cm; 58.0 ±6.4 kg; body fat 28.4 ± 2.8%) randomly underwent three experimental sessions: control (40 minutes of seated rest), RE leading to failure with 3 sets of 10 repetitions maximum (10-RM), and RE not to failure at 60% of 10-RM with 3 sets of 10 repetitions. Immediately post session BP and HRV were measured for 24 h. RESULTS: Ratings of perceived exertion and heart rate were higher during the 10-RM session when compared with 60% of 10-RM (6.4 ± 0.5 vs 3.5 ± 0.8 and 123.7 ± 13.9 vs 104.5 ± 7.3 bpm, respectively). The systolic, diastolic and mean BP decreased at 07:00 a.m. after the 10-RM session when compared with the control session (-9.0 ± 7.8 mmHg, -16.0 ± 12.9 mmHg and -14.3 ± 11.2 mmHg, respectively). The root mean square of the squared differences between R-R intervals decreased after both the 60% of 10-RM and 10-RM sessions compared with the control session. CONCLUSIONS: An acute RE session leading to failure induced a higher drop of BP upon awakening, while both RE sessions reduced cardiac parasympathetic modulation. RE may be an interesting training strategy to acutely decrease BP in adult women.


Assuntos
Pressão Sanguínea/fisiologia , Frequência Cardíaca/fisiologia , Esforço Físico/fisiologia , Treinamento Resistido/métodos , Adulto , Estudos Cross-Over , Feminino , Humanos
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