Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Adaptor protein-3 produces synaptic vesicles that release phasic dopamine.

Jain, Shweta; Yee, Andrew G; Maas, James; Gierok, Sarah; Xu, Hongfei; Stansil, Jasmine; Eriksen, Jacob; Nelson, Alexandra B; Silm, Katlin; Ford, Christopher P; Edwards, Robert H.

Proc Natl Acad Sci U S A ; 120(42): e2309843120, 2023 10 17.

Artigo em Inglês | MEDLINE | ID: mdl-37812725

2.

Altered Iron and Microstructure in Huntington's Disease Subcortical Nuclei: Insight From 7T MRI.

Yao, Jingwen; Morrison, Melanie A; Jakary, Angela; Avadiappan, Sivakami; Rowley, Paul; Glueck, Julia; Driscoll, Theresa; Geschwind, Michael D; Nelson, Alexandra B; Possin, Kathrine L; Xu, Duan; Hess, Christopher P; Lupo, Janine M.

J Magn Reson Imaging ; 2024 Jan 11.

Artigo em Inglês | MEDLINE | ID: mdl-38206986

3.

The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale in Spinocerebellar Ataxias.

Selvadurai, Louisa P; Perlman, Susan L; Ashizawa, Tetsuo; Wilmot, George R; Onyike, Chiadi U; Rosenthal, Liana S; Shakkottai, Vikram G; Paulson, Henry L; Subramony, Sub H; Bushara, Khalaf O; Kuo, Sheng-Han; Dietiker, Cameron; Geschwind, Michael D; Nelson, Alexandra B; Gomez, Christopher M; Opal, Puneet; Zesiewicz, Theresa A; Hawkins, Trevor; Yacoubian, Talene A; Nopoulos, Peggy C; Sha, Sharon J; Morrison, Peter E; Figueroa, Karla P; Pulst, Stefan M; Schmahmann, Jeremy D.

Cerebellum ; 2024 Jan 02.

Artigo em Inglês | MEDLINE | ID: mdl-38165578

4.

NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning.

Schonewille, Martijn; Girasole, Allison E; Rostaing, Philippe; Mailhes-Hamon, Caroline; Ayon, Annick; Nelson, Alexandra B; Triller, Antoine; Casado, Mariano; De Zeeuw, Chris I; Bouvier, Guy.

Proc Natl Acad Sci U S A ; 118(37)2021 09 14.

Artigo em Inglês | MEDLINE | ID: mdl-34507990

5.

Striatal Indirect Pathway Dysfunction Underlies Motor Deficits in a Mouse Model of Paroxysmal Dyskinesia.

Nelson, Alexandra B; Girasole, Allison E; Lee, Hsien-Yang; Ptácek, Louis J; Kreitzer, Anatol C.

J Neurosci ; 42(13): 2835-2848, 2022 03 30.

Artigo em Inglês | MEDLINE | ID: mdl-35165171

6.

Comparison of quantitative susceptibility mapping methods for iron-sensitive susceptibility imaging at 7T: An evaluation in healthy subjects and patients with Huntington's disease.

Yao, Jingwen; Morrison, Melanie A; Jakary, Angela; Avadiappan, Sivakami; Chen, Yicheng; Luitjens, Johanna; Glueck, Julia; Driscoll, Theresa; Geschwind, Michael D; Nelson, Alexandra B; Villanueva-Meyer, Javier E; Hess, Christopher P; Lupo, Janine M.

Neuroimage ; 265: 119788, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36476567

7.

The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications.

Selvadurai, Louisa P; Perlman, Susan L; Wilmot, George R; Subramony, Sub H; Gomez, Christopher M; Ashizawa, Tetsuo; Paulson, Henry L; Onyike, Chiadi U; Rosenthal, Liana S; Sair, Haris I; Kuo, Sheng-Han; Ratai, Eva-Maria; Zesiewicz, Theresa A; Bushara, Khalaf O; Öz, Gülin; Dietiker, Cameron; Geschwind, Michael D; Nelson, Alexandra B; Opal, Puneet; Yacoubian, Talene A; Nopoulos, Peggy C; Shakkottai, Vikram G; Figueroa, Karla P; Pulst, Stefan M; Morrison, Peter E; Schmahmann, Jeremy D.

Cerebellum ; 22(5): 790-809, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-35962273

8.

Frontostriatal Projections Regulate Innate Avoidance Behavior.

Loewke, Adrienne C; Minerva, Adelaide R; Nelson, Alexandra B; Kreitzer, Anatol C; Gunaydin, Lisa A.

J Neurosci ; 41(25): 5487-5501, 2021 06 23.

Artigo em Inglês | MEDLINE | ID: mdl-34001628

9.

Reassessing models of basal ganglia function and dysfunction.

Nelson, Alexandra B; Kreitzer, Anatol C.

Annu Rev Neurosci ; 37: 117-35, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25032493

10.

A diagnostic ceiling for exome sequencing in cerebellar ataxia and related neurological disorders.

Ngo, Kathie J; Rexach, Jessica E; Lee, Hane; Petty, Lauren E; Perlman, Susan; Valera, Juliana M; Deignan, Joshua L; Mao, Yuanming; Aker, Mamdouh; Posey, Jennifer E; Jhangiani, Shalini N; Coban-Akdemir, Zeynep H; Boerwinkle, Eric; Muzny, Donna; Nelson, Alexandra B; Hassin-Baer, Sharon; Poke, Gemma; Neas, Katherine; Geschwind, Michael D; Grody, Wayne W; Gibbs, Richard; Geschwind, Daniel H; Lupski, James R; Below, Jennifer E; Nelson, Stanley F; Fogel, Brent L.

Hum Mutat ; 41(2): 487-501, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31692161

11.

Striatal cholinergic neurotransmission requires VGLUT3.

Nelson, Alexandra B; Bussert, Timothy G; Kreitzer, Anatol C; Seal, Rebecca P.

J Neurosci ; 34(26): 8772-7, 2014 Jun 25.

Artigo em Inglês | MEDLINE | ID: mdl-24966377

12.

Dopamine across timescales and cell types: Relevance for phenotypes in Parkinson's disease progression.

Seiler, Jillian L; Zhuang, Xiaowen; Nelson, Alexandra B; Lerner, Talia N.

Exp Neurol ; 374: 114693, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38242300

13.

Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration.

Rademacher, Katerina; Doric, Zak; Haddad, Dominik; Mamaligas, Aphroditi; Liao, Szu-Chi; Creed, Rose B; Kano, Kohei; Chatterton, Zac; Fu, Yuhong; Garcia, Joseph H; Vance, Victoria; Sei, Yoshitaka; Kreitzer, Anatol; Halliday, Glenda M; Nelson, Alexandra B; Margolis, Elyssa B; Nakamura, Ken.

bioRxiv ; 2024 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-38645054

14.

A comparison of striatal-dependent behaviors in wild-type and hemizygous Drd1a and Drd2 BAC transgenic mice.

Nelson, Alexandra B; Hang, Giao B; Grueter, Brad A; Pascoli, Vincent; Luscher, Christian; Malenka, Robert C; Kreitzer, Anatol C.

J Neurosci ; 32(27): 9119-23, 2012 Jul 04.

Artigo em Inglês | MEDLINE | ID: mdl-22764221

15.

Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice.

Schor, Jonathan S; Gonzalez Montalvo, Isabelle; Spratt, Perry W E; Brakaj, Rea J; Stansil, Jasmine A; Twedell, Emily L; Bender, Kevin J; Nelson, Alexandra B.

Elife ; 112022 07 04.

Artigo em Inglês | MEDLINE | ID: mdl-35786442

16.

Distinct roles of GABAergic interneurons in the regulation of striatal output pathways.

Gittis, Aryn H; Nelson, Alexandra B; Thwin, Myo T; Palop, Jorge J; Kreitzer, Anatol C.

J Neurosci ; 30(6): 2223-34, 2010 Feb 10.

Artigo em Inglês | MEDLINE | ID: mdl-20147549

17.

Probing striatal microcircuitry to understand the functional role of cholinergic interneurons.

Girasole, Allison E; Nelson, Alexandra B.

Mov Disord ; 30(10): 1306-18, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26227561

18.

Directly to the Point: Dopamine Persistently Enhances Excitability of Direct Pathway Striatal Neurons.

McGregor, Matthew M; Nelson, Alexandra B.

Neuron ; 106(2): 201-203, 2020 04 22.

Artigo em Inglês | MEDLINE | ID: mdl-32325053

19.

Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.

Nelson, Alexandra B; Gittis, Aryn H; du Lac, Sascha.

Neuron ; 46(4): 623-31, 2005 May 19.

Artigo em Inglês | MEDLINE | ID: mdl-15944130

20.

Circuit Mechanisms of Parkinson's Disease.