[Anatomic and subjective success of structured surgical treatment strategy in the management of chronic epiphora - a postoperative analysis of contentment]. / Anatomischer und subjektiver Erfolg einer strukturierten chirurgischen Therapiestrategie zum Management der chronischen Epiphora - eine postoperative Zufriedenheitsanalyse.

BACKGROUND: Epiphora is the result of hypersecretion or reduced tear outflow because of relative or absolute obstruction of the lacrimal system. For the treatment a specific surgical procedure is usually required. Herein we present the subjective and objective findings of 243 consecutive patients with non-irritative induced epiphora, who underwent an operation in a standardised therapy scheme, which is used at the eye departments of the Universities of Lübeck and Würzburg. PATIENTS AND METHODS: In a retrospective cohort study 243 patients were included who underwent lateral tarsal strip (n = 72), external dacryocystorhinostomy (DCR) in the case of an absolute nasolacrimal duct obstruction (NLDO) (n = 116) and relative NLDO (n = 25), DCR with canalicular surgery (n = 18) and simple canalicular surgery (n = 12) with a follow-up of at least 6 month. Common patient and cosmetical satisfaction, intensity of symptoms and further symptoms of 168 patients were evaluated by sending a questionnaire with subsequent telephone survey. Objective findings were recorded from hospital charts. RESULTS: 59.5% of the patients were free of complaints, 19.6% had an absolute decrease of symptoms (epiphora outside and in windy weather) and 20.8 % persistent epiphora (symptoms both in- and outside persisted). 81% of patients with absolute NLDO and 57% with relative NLDO were graded as being free of symptoms, 7% (24%) as a relative decrease and 12% (19%) as a persistence of symptoms. There was a significant difference in success between these indications (p = 0.018). Patency of the lacrimal system assessed by irrigation was found in 95% (absolute NLDO). Commonly, 73.8% were satisfied, 7.7% indifferent and 18.4 % not satisfied. 4 patients were cosmetically not satisfied. CONCLUSIONS: Use of a standardised therapy scheme reduces the symptoms in 79.1% of the patients. In patients with absolute NLDO external DCR achieves an anatomic success rate of 95% and a subjective improvement in 88% with excellent cosmetic results. In comparison with absolute NLDO the success rate of relative NLDO is lower, but still with a subjective improvement in 81%. Our results show that postoperative success depends on the preoperative cause of the epiphora.

[Brachytherapy in combination with function-preserving surgery. An interdisciplinary challenge]. / Brachytherapie in Kombination mit zurückhaltender Chirurgie. Eine interdisziplinäre Herausforderung mit dem Ziel des Organerhalts.

A multimodal, interdisciplinary approach known as intensity-modified brachytherapy is a promising alternative for patients with advanced head and neck cancer infiltrating the orbita and skull base. An 87-year-old man presented with a recurrence of squamous cell carcinoma of the medial corner of the left eye that had been locally resected and irradiated by external beam radiotherapy multiple times. The cancer was resected with preservation of the eye with close margins, implantation of afterloading catheters, and reconstruction of the defect with a median forehead flap. The patient was irradiated with a total radiation dose of 30 Gy IMBT. After 1 year, there was no evidence of locoregional recurrence. The background of this therapeutic process and analysis of the current literature regarding this interdisciplinary treatment of head and neck cancer infiltrating the orbita and skull base are discussed based on this case report.

[Squamous cell carcinoma of the conjunctiva with orbital invasion: orbital exenteration or minimally invasive procedure?]. / Plattenepithelkarzinom der Bindehaut mit Orbitainvasion : Exenteratio orbitae oder minimal-invasives Vorgehen?

BACKGROUND: Here we present a case of a female patient with squamous cell carcinoma with orbital invasion who insisted on a globe-sparing excisional biopsy rather than a more invasive procedure. CASE: A 48-year-old patient presented with a conjunctival tumor at the medial canthus of the right eye. The visual acuity in this eye was 1.0. MRI showed a 25 mm x 12 mm tumor, with orbital invasion, no metastasis, but on CT scan damage of the lamina papyracea was suspected. Histology of a punch biopsy confirmed a moderately differentiated, squamous cell carcinoma. As requested by the patient, simple tumor excision with a 5-mm safety margin, reconstruction of the lower fornix with amniotic membrane, and adjuvant mitomycin C therapy were performed. Intraoperatively the medial orbital wall was found to be intact. No local or systemic recurrence has occurred 3.5 years postoperatively. The patient's VA is still 1.0; no visual field defects are detectable, and there are only minor upper lid levator restriction and diplopia in maximum upgaze. CONCLUSION: In view of this case the choice of surgical treatment for malignant tumors of the conjunctiva with orbital invasion - between exenteration or a minimally invasive procedure - should be carefully discussed with the patient. A follow-up of 5 years is strongly recommended.

[Gas permeable scleral lenses as a conservative treatment option for extreme corneal ectasias and severe dry eye]. / Gasdurchlässige Sklerallinsen als konservative Therapiealternative bei extremen Hornhautektasien und schwerem Tränenmangel.

PURPOSE: Due to their exclusive scleral contact zone, non-ventilated gas permeable scleral contact lenses can be used to correct extreme keratectasia, even if corneal fitted contact lenses failed previously. As the gap between the scleral lens and the cornea is filled with fluid substitutes, they also can be used for patients with severe aqueous-deficient dry eyes. PATIENTS, MATERIAL AND METHOD: Scleral lens fitting was attempted in 13 eyes (9 patients, group I) of patients with extreme corneal ectasia and 9 eyes (5 patients, group II) with severe ocular surface disease. Best corrected visual acuity, keratometry, Schirmer's test, foreign body sensation, and total daily lens wearing time were recorded prior to and after scleral lens fitting. RESULTS: Scleral lenses were successfully fitted and used on a long-term basis in 6 of 13 eyes (4 patients) of group I and 4 of 9 eyes of group II. In 9 eyes visual acuity increased by at least 2 lines, but long-term lens wear was not possible due to severe foreign body sensation or fornix shortening. CONCLUSIONS: Modern gas permeable scleral lenses can successfully be used for nonsurgical rehabilitation of severe corneal ectasia and dry eyes.

Relative mydriasis after photorefractive keratectomy.

PURPOSE: To report the incidence of anisocoria after unilateral excimer laser photorefractive keratectomy (PRK) for myopia and subsequent corticosteroid therapy in a retrospective and prospective study and to explore possible etiologies. METHODS: The horizontal pupil diameter was determined in 6 patients (6 eyes) at 21.8 +/- 12.6 months after unilateral wide-field excimer laser PRK (retrospective group) as well as in 8 consecutive patients (8 eyes) before and 3.4 +/- 2.9 months after unilateral PRK (prospective group). The Schwind-Keratom wide-field excimer laser was used. Measurements were done in an examination room using Rosenbaum card comparison pupillometry and with a Goldmann perimeter at 31.5 asb. In the prospective group, the effect of fitting a hard contact lens of zero diopter power and the application of 0.1% pilocarpine were evaluated. RESULTS: Relative mydriasis was present in all treated eyes and the difference in pupil diameter between the two eyes measured 0.25 to 1.75 mm (retrospective group: +0.56 +/- 0.82 mm; prospective group: +0.72 +/- 0.29 mm). At the time of pupil measurement, the retrospective group had a significantly longer mean postoperative follow-up (21 mo) than the prospective group (3.4 mo) and significantly more eyes still received topical corticosteroid treatment (retrospective group, 1 of 6 eyes; prospective group, 7 of 8 eyes). The amount of anisocoria did not correlate with the applied laser energy, ablation depth, or refractive change, but showed a negative correlation with increasing time after PRK. Neither hard contact lens fitting nor pilocarpine 0.1% reduced the amount of anisocoria significantly. CONCLUSION: Unilateral PRK with wide-field excimer laser ablation and subsequent application of topical corticosteroids regularly resulted in a relative pupillary mydriasis. Neither an altered corneal profile nor parasympathetic denervation is responsible for this. Weakening of the pupillary sphincter of the treated eye may cause this phenomenon.

[Anisocoria after unilateral photorefractive keratectomy. Result of a lesion of the pupillary sphincter muscle?]. / Anisokorie nach einseitiger photorefraktiver Keratektomie. Ausdruck einer Läsion des Pupillensphinktermuskels?

BACKGROUND: After unilateral photorefractive keratectomy (PRK) for myopia correction, relative mydriasis of the treated eye was noticed. The aim of this study was to determine the incidence and possible etiology of this anisocoria. PATIENTS AND METHODS: In a prospective clinical study we examined eight consecutive patients after PRK of a spherical equivalent of -1.0 to -8.5 D with a 6.5-7.0 mm optical zone (Schwind-Keratom) for up to 10 months. Measurements of the pharmacological uninfluenced pupillary diameter were carried out with a Goldmann perimeter under 31.5 asb and under four different room light and distance conditions. In five patients a hard contact lens of 0 D power was fitted to the treated eye, so that the laser-induced central corneal flattening was compensated for by the sublenticular tear film, and the pupillary diameter was measured again. The influence of pilocarpine 0.1% eye drops to the pupil was also examined. RESULTS: Postoperatively, the pupil of the PRK-treated eye measured up to 1.75 mm larger than that of the fellow eye in all patients. The amount of anisocoria showed a small negative correlation with the interval between the PRK procedure and the day of measurement. It did not correlate significantly with the amount of induced refractive change, applied energy, application of pilocarpine 0.1% eye drops or the contact lens fitting. CONCLUSION: After unilateral PRK, anisocoria can regularly be observed. At present its definite pathogenesis is unclear, although certain possible optical and neuronal mechanisms have been excluded. The most probable etiology is a mild lesion of the pupillary sphincter muscle because of its localization in the center of the laser shock wave distribution.

[Chronic open angle glaucoma: correlation of pattern electroretinography and visual field indices]. / Chronisches Offenwinkelglaukom: Korrelation von Musterelektroretinogramm und Gesichtsfeldindizes.

The pattern electroretinogram has already proven to be useful in detecting early stages of chronic open-angle glaucoma. We were interested in the degree of correlation between pattern ERG amplitudes and definite visual field defects. Fifteen glaucoma patients with a wide range of visual field defects were examined with pattern electroretinogram (stimulus with reversal rate of 8/s, checksizes of 0.9 degree and 6.9 degrees, covering a visual field of up to 9 degrees eccentricity). The patients' visual fields obtained with the Octopus 1-2-3 perimeter were analyzed with the perimetric analysis system PERIDATA using the indices of conformity for localized defects and the regional indices created from the mean deviation in certain parts of the 30 degrees field. In our results we were only able to find a significant correlation within the 5% level between the pattern ERG amplitudes and the sector index (large checksize, correlation coefficient r = -0.58, p = 0.03) and with the mean deviation in the region between 10 degrees and 20 degrees (small checksize, r = -0.538, p = 0.044). In summary, a marginal correlation between electrophysiological data and perimetric parameters was demonstrated. We try to explain the remarkable correlation between the amplitudes (small pattern) that were recorded from the central 9 degrees with the mean defects from the visual field peripheral of 10 degrees with the frequent combination of diffuse and localized field defects in glaucoma. Examination with the pattern ERG alone does not seem to be appropriate for grading the focal glaucomatous damage.

[Pattern electroretinography in routine clinical diagnosis of open angle glaucoma]. / Musterelektroretinogramm in der klinischen Routinediagnostik des chronischen Offenwinkelglaukoms.

According to current opinion, the pattern electroretinogram (ERG) is generated in the retinal ganglion cells. Therefore, the amplitude is expected to be reduced in diseases of the optic nerve. This leads to the conclusion that the pattern ERG might be applied in detecting ganglion cell loss in the routine clinical diagnosis of chronic open-angle glaucoma. Pattern ERGs were recorded in 15 patients with defined chronic open-angle glaucoma and 21 control individuals using a DTL fiber electrode at two different check sizes. A Fourier analysis of the ERG results reduces the subjectivity when analysing the amplitudes on screen and implies the possibility of multicentric comparability. The reliability of coordinating a value of a future patient to the correct group was estimated to 82% for the Fourier data by the bivariate discriminant analysis, based on the amplitudes of both check sizes. In this way, the relatively high interindividual variability will be partly overcome. The ability of the ERG amplitudes to separate glaucoma patients from healthy persons was determined by the AUC value, using a combination of sensitivity and specificity extracted from the ROC curves. The AUC value has its maximum at 1.0. We found an AUC value of 0.8, which confirmed the information given by the pattern ERG amplitudes. Healthy individuals and glaucoma patients cannot be separated completely by the procedure but, combined with additional clinical parameters, further validation can be achieved.

[Prominent conjunctival tumor]. / Prominenter Bindehauttumor.

The case of a 57-year-old woman with a rapidly growing unpigmented conjunctival tumor is presented. Despite the clinical appearance the histology surprisingly confirmed a malignant melanoma of the conjunctiva. Various phenotypes and the rareness of this disease complicate a clinical diagnosis. Therapeutically, a complete excision of the tumor including a safety margin, adjuvant topical chemotherapy and closely monitored follow-up are crucial.

Differential vestibular dysfunction in sudden unilateral hearing loss.

Auditory and vestibular function was examined in 29 patients with unilateral sensorineural hearing loss to identify characteristic vestibulocochlear lesion patterns. In 45%, a vestibular lesion was found, of which 53% had a combined impairment of the cochlea and the ipsilateral posterior semicircular canal, possibly reflecting vascular disease in the common cochlear artery.

[Measles retinitis in an immunocompetent child]. / Masern-Retinitis bei einem immunkompetenten Kind.

BACKGROUND: Measles retinitis is rare in immunocompetent patients and has recently been only sporadically described. This case report reveals the clinical picture, the course of the disease and the prognosis of this entity. HISTORY AND FINDINGS: One month after a diagnosed measles infection, a 12-year-old girl presented with a macular star and peripheral retinal oedema due to a diffuse vasculitis associated with visual impairment in both eyes. Perimetry, electroretinography, and fluorescein angiography revealed a necrotising process along the inflamed vessels. THERAPY AND COURSE: Without therapy vision improved and the macular changes decreased. Some of the paracentral scotomata and a discrete visual acuity defect could still be detected during the follow-up examinations after 2 1/2 and 7 months. CONCLUSIONS: The early diagnosis of measles retinitis by an ophthalmologist can be of great importance because an associated encephalitis could be treated medically if recognized early enough.

[Juvenile neuronal ceroid lipofuscinosis (Spielmeyer-Vogt disease)]. / Juvenile Neuronale Ceroid-Lipofuszinose (M. Spielmeyer-Vogt).

BACKGROUND: The neuronal ceroid-lipofuscinosis (NCL) belongs to progressive neurodegenerative disorders of childhood with both ophthalmologic and neurologic symptoms. In the most common type in Germany, the juvenile type, the ophthalmological examination is essential for an early diagnosis. PATIENT: A 5-year-old boy had exhibited a loss of visual acuity, visual field and colour perception in his pre-school age. His clinical features and electrophysiologic data are presented. The final diagnostic clues were drawn from the neuropediatric and cytologic examinations. RESULTS: This patient shows the typical clinical feature of the juvenile NCL with a relatively rapid visual loss with bull's eye maculopathy in the pre-school- to early school age. His electroretinogram was abolished, and his EEG showed pathologic results. The diagnosis could be established by electron microscopy of his lymphocytes. Epilepsy and intellectual defects are expected to set in only few years later. CONCLUSIONS: Although there is no therapy, the ophthalmologist should be aware of this rare entity because prognostic counselling, social help and perhaps genetic counselling could be offered to the families. In many cases, a prenatal diagnosis is possible.

[Endogenous candida endophthalmitis in a drug dependent patient: intravenous therapy with liposome encapsulated amphotericin B]. / Endogene Candida-Endophthalmitis bei einem Drogenabhängigen: intravenöse Therapie mit liposomal verkapseltem Amphotericin B.

We report this exemplary case of a drug addict with candida endophthalmitis where we used the new form of amphotericin B, encapsulated in liposomes. We were able to reconfirm the reduced number of side effects and the minimized nephrotoxicity reported by authors of other specialties. In our patient, a reduction or elimination of the yeast was probably achieved, nevertheless, he developed a traction retinal detachment. In future cases of fungal endophthalmitis, we recommend liposomal amphotericin B in higher doses.

R124C mutation of the betaIGH3 gene leads to remarkable phenotypic variability in a Greek four-generation family with lattice corneal dystrophy type 1.

Five autosomal dominantly inherited corneal dystrophies are caused by missense mutations in the betaIGH3 gene on chromosome 5q31. Here we describe the clinical features and the analysis of the betaIGH3 gene in a Greek four-generation family with lattice corneal dystrophy type 1 (CDL1). Sequencing of the betaIGH3 cDNA from an affected family member revealed the R124C mutation. More recent data indicate that this is probably a mutation hot spot in CDL1. We could not find a common haplotype with another CDL1 family with the R124C mutation demonstrating that this mutation occurs independently in different families. The clinical course of the disease showed a remarkable variability between the affected family members. To investigate a possible role between the phenotypic variability and apolipoprotein E (ApoE), which co-localises with amyloid deposits in CDL1, we determined the ApoE genotype of all family members. The resulting data revealed no association with the variable clinical course.