Detalhe da pesquisa
1.
Discovery, characterization, and lead optimization of 7-azaindole non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorg Med Chem Lett
; 26(16): 4101-5, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27390064
2.
Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.
Bioorg Med Chem Lett
; 25(17): 3711-5, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26099532
3.
Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs.
Nucleic Acids Res
; 40(1): 381-90, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21914723
4.
Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 23(7): 2031-4, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23466233
5.
Drugs that target dynamic microtubules: a new molecular perspective.
Med Res Rev
; 31(3): 443-81, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21381049
6.
Selection and characterization of HIV-1 with a novel S68 deletion in reverse transcriptase.
Antimicrob Agents Chemother
; 55(5): 2054-60, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21357304
7.
The tubulin binding mode of microtubule stabilizing agents studied by electron crystallography.
Top Curr Chem
; 286: 209-57, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-23563614
8.
Approaches for the development of antiviral compounds: the case of hepatitis C virus.
Handb Exp Pharmacol
; (189): 25-51, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19048196
9.
Rational design of the microtubule-targeting anti-breast cancer drug EM015.
Cancer Res
; 66(7): 3782-91, 2006 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16585205
10.
Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function.
Mol Cancer Ther
; 6(4): 1317-28, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17431110
11.
"Plate cherry picking": a novel semi-sequential screening paradigm for cheaper, faster, information-rich compound selection.
J Biomol Screen
; 12(3): 320-7, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17438067
12.
Flexible 3D pharmacophores as descriptors of dynamic biological space.
J Mol Graph Model
; 26(3): 622-33, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17395510
13.
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules.
Mol Cancer Ther
; 5(2): 270-8, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16505100
14.
Substrates and Inhibitors of SAMHD1.
PLoS One
; 12(1): e0169052, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28046007
15.
Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptors.
J Med Chem
; 49(23): 6802-10, 2006 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17154510
16.
Ligand similarity guided receptor selection enhances docking accuracy and recall for non-nucleoside HIV reverse transcriptase inhibitors.
J Mol Model
; 21(11): 282, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26450349
17.
Approaches to hepatitis C treatment and cure using NS5A inhibitors.
Infect Drug Resist
; 7: 41-56, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24623983
18.
Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition.
J Med Chem
; 57(23): 10031-43, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25365735
19.
Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV.
PLoS One
; 9(1): e86997, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24498008
20.
Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.
Eur J Med Chem
; 46(9): 3832-44, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21700368