RESUMO
The individual effects of verapamil and 2 antioxidants on perfused rat liver nucleoside triphosphate (NTP) recovery following cold storage in University of Wisconsin (UW) solution was assessed using 31P nuclear magnetic resonance spectroscopy. The pharmacological agents were added to UW solution and were present only during organ storage. NTP recovery was significantly higher for the 24-hr UW + 40 microM verapamil group as compared with the 24-hr UW group. None of the other pharmacological agents caused a significant increase in NTP recovery. These findings suggest that addition of verapamil to UW organ preservation solution may result in better poststorage liver function.
Assuntos
Fígado/metabolismo , Soluções para Preservação de Órgãos , Preservação de Órgãos , Acetilcisteína/farmacologia , Adenosina/farmacologia , Alopurinol/farmacologia , Animais , Antioxidantes/farmacologia , Cromanos/farmacologia , Glutationa/farmacologia , Insulina/farmacologia , Espectroscopia de Ressonância Magnética , Masculino , Nucleotídeos/análise , Perfusão , Rafinose/farmacologia , Ratos , Ratos Sprague-Dawley , Verapamil/farmacologiaRESUMO
Radial artery pseudoaneurysms are rare, and those that become infected are rarer still. We present the case of a patient who developed a radial artery pseudoaneurysm as a late complication of arterial catheterization. Blood cultures were positive for Staphylococcus aureus, and a pulsatile mass, with associated tissue necrosis, was palpable over the radial artery. The diagnosis was confirmed by gray-scale and color Doppler sonography, which showed a partially thrombosed pseudoaneurysm and turbulent flow in the pseudoaneurysm and native artery.
Assuntos
Falso Aneurisma/etiologia , Aneurisma Infectado/etiologia , Cateterismo Cardíaco/efeitos adversos , Artéria Radial , Infecções Estafilocócicas/etiologia , Idoso , Idoso de 80 Anos ou mais , Falso Aneurisma/diagnóstico por imagem , Aneurisma Infectado/diagnóstico por imagem , Cateterismo Cardíaco/métodos , Insuficiência Cardíaca/diagnóstico , Humanos , Masculino , Sensibilidade e Especificidade , Infecções Estafilocócicas/diagnóstico por imagem , Ultrassonografia Doppler em CoresRESUMO
PURPOSE: To determine the arteriographic incidence and severity of renal arterial disease in potential renal donors and to evaluate the effect of identifying vascular abnormalities on subsequent donor surgery. MATERIALS AND METHODS: The records of 716 potential living renal donors who underwent conventional arteriography were reviewed. Abnormal arteriograms were reexamined to characterize vascular disease, and the effect of identifying renovascular disease on subsequent donor surgery was ascertained with chart review. RESULTS: Renovascular abnormalities were noted in the dictated reports in 78 patients (10.9%). The most common causes were fibromuscular dysplasia and atherosclerosis. The arteriograms of 64 patients were available for retrospective review. Abnormalities were characterized as minimal stenosis (<30% narrowing) in 42 patients and mild stenosis (30%-50% narrowing) in 19 of 61 patients with arteriographic abnormalities at retrospective review. In three patients, no significant abnormality was seen at retrospective review. The effect of detecting renovascular disease on donor selection was determined in 74 of the 78 patients. In 73 of these 74 patients (99%), detection of an abnormality directly affected donor surgery. CONCLUSION: In this population of potential renal donors, the arteriographic incidence of renovascular disease (10.9%) was higher than previously reported. Although renovascular abnormalities were mild, their detection influenced the plan for donor surgery in almost all patients.