Detalhe da pesquisa
1.
Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation.
Neurobiol Dis
; 157: 105426, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34144124
2.
Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism.
Int J Mol Sci
; 22(3)2021 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33494262
3.
Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics.
J Biol Chem
; 294(15): 5907-5913, 2019 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30796162
4.
LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients.
Mov Disord
; 34(3): 406-415, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30597610
5.
P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.
Biochem J
; 475(7): 1271-1293, 2018 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29519959
6.
LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies.
Mov Disord
; 32(3): 423-432, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27911006
7.
Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain.
Proc Natl Acad Sci U S A
; 111(11): 4055-60, 2014 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24591621
8.
LRRK2 dephosphorylation increases its ubiquitination.
Biochem J
; 469(1): 107-20, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25939886
9.
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.
Biochem J
; 456(1): 119-28, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23937259
10.
Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity.
Cell Rep
; 42(5): 112447, 2023 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37141099
11.
PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation.
Front Mol Neurosci
; 16: 1269387, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38169846
12.
Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition.
J Neurochem
; 120(1): 37-45, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22004453
13.
Pharmacological inhibition of LRRK2 cellular phosphorylation sites provides insight into LRRK2 biology.
Biochem Soc Trans
; 40(5): 1158-62, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22988882
14.
Discovery of 1H-Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors.
ACS Med Chem Lett
; 13(6): 981-988, 2022 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35707141
15.
Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy.
Eur J Med Chem
; 229: 114080, 2022 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34992038
16.
Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors.
Eur J Med Chem
; 242: 114693, 2022 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36049274
17.
A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively.
Cells
; 11(6)2022 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35326469
18.
Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity.
J Parkinsons Dis
; 12(5): 1423-1447, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35599495
19.
The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.
J Cell Biol
; 221(4)2022 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35266954
20.
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.
Biochem J
; 430(3): 405-13, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20659021