Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast.

Qin, Ning; Li, Lingyun; Ji, Xu; Pereira, Rui; Chen, Yu; Yin, Shile; Li, Chaokun; Wan, Xiaozhen; Qiu, Danye; Jiang, Junfeng; Luo, Hao; Zhang, Yueping; Dong, Genlai; Zhang, Yiming; Shi, Shuobo; Jessen, Henning J; Xia, Jianye; Chen, Yun; Larsson, Christer; Tan, Tianwei; Liu, Zihe; Nielsen, Jens.

Cell ; 186(4): 748-763.e15, 2023 02 16.

Artigo em Inglês | MEDLINE | ID: mdl-36758548

2.

Bioactive metabolites: The double-edged sword in your food.

Nielsen, Jens.

Cell ; 185(24): 4469-4471, 2022 11 23.

Artigo em Inglês | MEDLINE | ID: mdl-36423578

3.

Antibiotic Lethality Is Impacted by Nutrient Availabilities: New Insights from Machine Learning.

Nielsen, Jens.

Cell ; 177(6): 1373-1374, 2019 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-31150617

4.

Reprogramming Yeast Metabolism from Alcoholic Fermentation to Lipogenesis.

Yu, Tao; Zhou, Yongjin J; Huang, Mingtao; Liu, Quanli; Pereira, Rui; David, Florian; Nielsen, Jens.

Cell ; 174(6): 1549-1558.e14, 2018 09 06.

Artigo em Inglês | MEDLINE | ID: mdl-30100189

5.

Systems Biology of Metabolism.

Nielsen, Jens.

Annu Rev Biochem ; 86: 245-275, 2017 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-28301739

6.

Engineering Cellular Metabolism.

Nielsen, Jens; Keasling, Jay D.

Cell ; 164(6): 1185-1197, 2016 Mar 10.

Artigo em Inglês | MEDLINE | ID: mdl-26967285

7.

Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation.

Healey, Jeff S; Lopes, Renato D; Granger, Christopher B; Alings, Marco; Rivard, Lena; McIntyre, William F; Atar, Dan; Birnie, David H; Boriani, Giuseppe; Camm, A John; Conen, David; Erath, Julia W; Gold, Michael R; Hohnloser, Stefan H; Ip, John; Kautzner, Josef; Kutyifa, Valentina; Linde, Cecilia; Mabo, Philippe; Mairesse, Georges; Benezet Mazuecos, Juan; Cosedis Nielsen, Jens; Philippon, Francois; Proietti, Marco; Sticherling, Christian; Wong, Jorge A; Wright, David J; Zarraga, Ignatius G; Coutts, Shelagh B; Kaplan, Andrew; Pombo, Marta; Ayala-Paredes, Felix; Xu, Lizhen; Simek, Kim; Nevills, Sandra; Mian, Rajibul; Connolly, Stuart J.

N Engl J Med ; 390(2): 107-117, 2024 Jan 11.

Artigo em Inglês | MEDLINE | ID: mdl-37952132

8.

Combinatorial, additive and dose-dependent drug-microbiome associations.

Forslund, Sofia K; Chakaroun, Rima; Zimmermann-Kogadeeva, Maria; Markó, Lajos; Aron-Wisnewsky, Judith; Nielsen, Trine; Moitinho-Silva, Lucas; Schmidt, Thomas S B; Falony, Gwen; Vieira-Silva, Sara; Adriouch, Solia; Alves, Renato J; Assmann, Karen; Bastard, Jean-Philippe; Birkner, Till; Caesar, Robert; Chilloux, Julien; Coelho, Luis Pedro; Fezeu, Leopold; Galleron, Nathalie; Helft, Gerard; Isnard, Richard; Ji, Boyang; Kuhn, Michael; Le Chatelier, Emmanuelle; Myridakis, Antonis; Olsson, Lisa; Pons, Nicolas; Prifti, Edi; Quinquis, Benoit; Roume, Hugo; Salem, Joe-Elie; Sokolovska, Nataliya; Tremaroli, Valentina; Valles-Colomer, Mireia; Lewinter, Christian; Søndertoft, Nadja B; Pedersen, Helle Krogh; Hansen, Tue H; Gøtze, Jens Peter; Køber, Lars; Vestergaard, Henrik; Hansen, Torben; Zucker, Jean-Daniel; Hercberg, Serge; Oppert, Jean-Michel; Letunic, Ivica; Nielsen, Jens; Bäckhed, Fredrik; Ehrlich, S Dusko.

Nature ; 600(7889): 500-505, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34880489

9.

Brain energy metabolism is optimized to minimize the cost of enzyme synthesis and transport.

Gustafsson, Johan; Robinson, Jonathan L; Zetterberg, Henrik; Nielsen, Jens.

Proc Natl Acad Sci U S A ; 121(7): e2305035121, 2024 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-38315844

10.

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis.

Vieira-Silva, Sara; Falony, Gwen; Belda, Eugeni; Nielsen, Trine; Aron-Wisnewsky, Judith; Chakaroun, Rima; Forslund, Sofia K; Assmann, Karen; Valles-Colomer, Mireia; Nguyen, Thi Thuy Duyen; Proost, Sebastian; Prifti, Edi; Tremaroli, Valentina; Pons, Nicolas; Le Chatelier, Emmanuelle; Andreelli, Fabrizio; Bastard, Jean-Phillippe; Coelho, Luis Pedro; Galleron, Nathalie; Hansen, Tue H; Hulot, Jean-Sébastien; Lewinter, Christian; Pedersen, Helle K; Quinquis, Benoit; Rouault, Christine; Roume, Hugo; Salem, Joe-Elie; Søndertoft, Nadja B; Touch, Sothea; Dumas, Marc-Emmanuel; Ehrlich, Stanislav Dusko; Galan, Pilar; Gøtze, Jens P; Hansen, Torben; Holst, Jens J; Køber, Lars; Letunic, Ivica; Nielsen, Jens; Oppert, Jean-Michel; Stumvoll, Michael; Vestergaard, Henrik; Zucker, Jean-Daniel; Bork, Peer; Pedersen, Oluf; Bäckhed, Fredrik; Clément, Karine; Raes, Jeroen.

Nature ; 581(7808): 310-315, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32433607

11.

Yeast increases glycolytic flux to support higher growth rates accompanied by decreased metabolite regulation and lower protein phosphorylation.

Chen, Min; Xie, Tingting; Li, Huan; Zhuang, Yingping; Xia, Jianye; Nielsen, Jens.

Proc Natl Acad Sci U S A ; 120(25): e2302779120, 2023 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-37307493

12.

Generation and analysis of context-specific genome-scale metabolic models derived from single-cell RNA-Seq data.

Gustafsson, Johan; Anton, Mihail; Roshanzamir, Fariba; Jörnsten, Rebecka; Kerkhoven, Eduard J; Robinson, Jonathan L; Nielsen, Jens.

Proc Natl Acad Sci U S A ; 120(6): e2217868120, 2023 02 07.

Artigo em Inglês | MEDLINE | ID: mdl-36719923

13.

HGTphyloDetect: facilitating the identification and phylogenetic analysis of horizontal gene transfer.

Yuan, Le; Lu, Hongzhong; Li, Feiran; Nielsen, Jens; Kerkhoven, Eduard J.

Brief Bioinform ; 24(2)2023 03 19.

Artigo em Inglês | MEDLINE | ID: mdl-36752380

14.

Molecular biology for green recovery-A call for action.

Rodríguez-Martínez, Marta; Nielsen, Jens; Dupont, Sam; Vamathevan, Jessica; Glover, Beverley J; Crosswell, Lindsey C; Rouse, Brendan; Luisi, Ben F; Bowler, Chris; Gasser, Susan M; Arendt, Detlev; Erb, Tobias J; de Lorenzo, Victor; Heard, Edith; Patil, Kiran Raosaheb.

PLoS Biol ; 20(4): e3001623, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35452449

15.

GotEnzymes: an extensive database of enzyme parameter predictions.

Li, Feiran; Chen, Yu; Anton, Mihail; Nielsen, Jens.

Nucleic Acids Res ; 51(D1): D583-D586, 2023 01 06.

Artigo em Inglês | MEDLINE | ID: mdl-36169223

16.

Yeast has evolved to minimize protein resource cost for synthesizing amino acids.

Chen, Yu; Nielsen, Jens.

Proc Natl Acad Sci U S A ; 119(4)2022 01 25.

Artigo em Inglês | MEDLINE | ID: mdl-35042799

17.

Metastatic triple negative breast cancer adapts its metabolism to destination tissues while retaining key metabolic signatures.

Roshanzamir, Fariba; Robinson, Jonathan L; Cook, Daniel; Karimi-Jafari, Mohammad Hossein; Nielsen, Jens.

Proc Natl Acad Sci U S A ; 119(35): e2205456119, 2022 08 30.

Artigo em Inglês | MEDLINE | ID: mdl-35994654

18.

Genome-scale modeling drives 70-fold improvement of intracellular heme production in Saccharomyces cerevisiae.

Ishchuk, Olena P; Domenzain, Iván; Sánchez, Benjamín J; Muñiz-Paredes, Facundo; Martínez, José L; Nielsen, Jens; Petranovic, Dina.

Proc Natl Acad Sci U S A ; 119(30): e2108245119, 2022 07 26.

Artigo em Inglês | MEDLINE | ID: mdl-35858410

19.

Noninvasive detection of any-stage cancer using free glycosaminoglycans.

Bratulic, Sinisa; Limeta, Angelo; Dabestani, Saeed; Birgisson, Helgi; Enblad, Gunilla; Stålberg, Karin; Hesselager, Göran; Häggman, Michael; Höglund, Martin; Simonson, Oscar E; Stålberg, Peter; Lindman, Henrik; Bång-Rudenstam, Anna; Ekstrand, Matias; Kumar, Gunjan; Cavarretta, Ilaria; Alfano, Massimo; Pellegrino, Francesco; Mandel-Clausen, Thomas; Salanti, Ali; Maccari, Francesca; Galeotti, Fabio; Volpi, Nicola; Daugaard, Mads; Belting, Mattias; Lundstam, Sven; Stierner, Ulrika; Nyman, Jan; Bergman, Bengt; Edqvist, Per-Henrik; Levin, Max; Salonia, Andrea; Kjölhede, Henrik; Jonasch, Eric; Nielsen, Jens; Gatto, Francesco.

Proc Natl Acad Sci U S A ; 119(50): e2115328119, 2022 12 13.

Artigo em Inglês | MEDLINE | ID: mdl-36469776

20.

Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged ≥50 Years: Assessing Variability Across Denmark and Spain.

López-Lacort, Mónica; Amini, Marzyeh; Emborg, Hanne-Dorthe; Nielsen, Jens; McDonald, Scott A; Valentiner-Branth, Palle; Díez-Domingo, Javier; Orrico-Sánchez, Alejandro.

J Infect Dis ; 2024 Mar 09.

Artigo em Inglês | MEDLINE | ID: mdl-38459772

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Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast.

Bioactive metabolites: The double-edged sword in your food.

Antibiotic Lethality Is Impacted by Nutrient Availabilities: New Insights from Machine Learning.

Reprogramming Yeast Metabolism from Alcoholic Fermentation to Lipogenesis.

Systems Biology of Metabolism.

Engineering Cellular Metabolism.

Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation.

Combinatorial, additive and dose-dependent drug-microbiome associations.

Brain energy metabolism is optimized to minimize the cost of enzyme synthesis and transport.

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis.

Yeast increases glycolytic flux to support higher growth rates accompanied by decreased metabolite regulation and lower protein phosphorylation.

Generation and analysis of context-specific genome-scale metabolic models derived from single-cell RNA-Seq data.

HGTphyloDetect: facilitating the identification and phylogenetic analysis of horizontal gene transfer.

Molecular biology for green recovery-A call for action.

GotEnzymes: an extensive database of enzyme parameter predictions.

Yeast has evolved to minimize protein resource cost for synthesizing amino acids.

Metastatic triple negative breast cancer adapts its metabolism to destination tissues while retaining key metabolic signatures.

Genome-scale modeling drives 70-fold improvement of intracellular heme production in Saccharomyces cerevisiae.

Noninvasive detection of any-stage cancer using free glycosaminoglycans.

Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged ≥50 Years: Assessing Variability Across Denmark and Spain.