High-Performance Novel Polyoxometalate-LDH Nanocomposite-Modified Thin-Film Nanocomposite Forward Osmosis Membranes: A Study of Desalination and Antifouling Performance.

Numerous investigations have focused on creating effective membranes for desalination in order to alleviate the water scarcity crisis. In this study, first, LDH nanoplates were synthesized and utilized to alter the surface of thin-film composite (TFC) membranes in the course of this investigation. Following that, a simple technique was used to produce a novel nanocomposite incorporating LDH layers and Na14(P2W18Co4O70)·28H2O polyoxometalate nanoparticles, resulting in the creation of a fresh variety of thin-film nanocomposite (TFN). The performance of all of the membranes acquired was examined in the process of forward osmosis (FO). The impact of the compounds that were prepared was assessed on the hydrophilicity, topology, chemical structure, and morphology of the active layer of polyamide (PA) through analysis methods such as atomic force microscopy (AFM), energy-dispersive X-ray (EDX), FTIR spectroscopy, powder X-ray diffraction (XRD), scanning electron microscopy (SEM), and water contact angle (WCA) goniometry. After evaluating the outcomes of both modified membrane types, it was observed that the membrane equipped with the nanocomposite modifier at a concentration of 0.01 wt % exhibited the highest water flux, measuring 46.6 LMH and selectivity of 0.23 g/L. This membrane was thus considered the best option. Furthermore, the membrane's ability to prevent fouling was examined, and the findings revealed an enhancement in its resistance to fouling in comparison to the filler-free membrane.

Feasibility of a kinect-based system in assessing physical function of the elderly for home-based care.

BACKGROUND: With concerns about accurate diagnosis through telehealth, the Kinect sensor offers a reliable solution for movement analysis. However, there is a lack of practical research investigating the suitability of a Kinect-based system as a functional fitness assessment tool in homecare settings. Hence, the objective of this study was to evaluate the feasibility of using a Kinect-based system to assess physical function changes in the elderly. METHODS: The study consisted of two phases. Phase one involved 35 young healthy adults, evaluating the reliability and validity of a Kinect-based fitness evaluation compared to traditional physical examination using the intraclass correlation coefficient (ICC). Phase two involved 665 elderly subjects, examining the correlation between the Kinect-based fitness evaluation and physical examination through Pearson's correlation coefficients. A Kinect sensor (Microsoft Xbox One Kinect V2) with customized software was employed to capture and compute the movement of joint centers. Both groups performed seven functional assessments simultaneously monitored by a physical therapist and the Kinect system. System usability and user satisfaction were assessed using the System Usability Scale (SUS) and Questionnaire for User Interface Satisfaction (QUIS), respectively. RESULTS: Kinect-based system showed overall moderate to excellent within-day reliability (ICC = 0.633-1.0) and between-day reliability (ICC = 0.686-1.0). The overall agreement between the two devices was highly correlated (r ≧ 0.7) for all functional assessment tests in young healthy adults. The Kinect-based system also showed a high correlation with physical examination for the functional assessments (r = 0.858-0.988) except functional reach (r = 0.484) and walking speed(r = 0.493). The users' satisfaction with the system was excellent (SUS score = 84.4 ± 18.5; QUIS score = 6.5-6.7). CONCLUSIONS: The reliability and validity of Kinect for assessing functional performance are generally favorable. Nonetheless, caution is advised when employing Kinect for tasks involving depth changes, such as functional reach and walking speed tests for their moderate validity. However, Kinect's fundamental motion detection capabilities demonstrate its potential for future applications in telerehabilitation in different healthcare settings.

Frailty Level Classification of the Community Elderly Using Microsoft Kinect-Based Skeleton Pose: A Machine Learning Approach.

Frailty is one of the most important geriatric syndromes, which can be associated with increased risk for incident disability and hospitalization. Developing a real-time classification model of elderly frailty level could be beneficial for designing a clinical predictive assessment tool. Hence, the objective of this study was to predict the elderly frailty level utilizing the machine learning approach on skeleton data acquired from a Kinect sensor. Seven hundred and eighty-seven community elderly were recruited in this study. The Kinect data were acquired from the elderly performing different functional assessment exercises including: (1) 30-s arm curl; (2) 30-s chair sit-to-stand; (3) 2-min step; and (4) gait analysis tests. The proposed methodology was successfully validated by gender classification with accuracies up to 84 percent. Regarding frailty level evaluation and prediction, the results indicated that support vector classifier (SVC) and multi-layer perceptron (MLP) are the most successful estimators in prediction of the Fried's frailty level with median accuracies up to 97.5 percent. The high level of accuracy achieved with the proposed methodology indicates that ML modeling can identify the risk of frailty in elderly individuals based on evaluating the real-time skeletal movements using the Kinect sensor.

Enzymatic denaturation versus excessive fatigue loading degeneration: Effects on the time-dependent response of the intervertebral disc.

Degenerative disc disease (DDD), regardless of its phenotype and clinical grade, is widely associated with low back pain (LBP), which remains the single leading cause of disability worldwide. This work provides a quantitative methodology for comparatively investigating artificial IVD degeneration via two popular approaches: enzymatic denaturation and fatigue loading. An in-vitro animal study was used to study the time-dependent responses of forty fresh juvenile porcine thoracic IVDs in conjunction with inverse and forward finite element (FE) simulations. The IVDs were dissected from 6-month-old-juvenile pigs and equally assigned to 5 groups (intact, denatured, low-level, medium-level, high-level fatigue loading). Upon preloading, a sinusoid cyclic load (Peak-to-peak/0.1-to-0.8 MPa) was applied (0.01-10 Hz), and dynamic-mechanical-analyses (DMA) was performed. The DMA outcomes were integrated with a robust meta-model analysis to quantify the poroelastic IVD characteristics, while specimen-specific FE models were developed to study the detailed responses. The results demonstrated that enzymatic denaturation had a more significantly pronounced effect on the resistive strength and shock attenuation capabilities of the intervertebral discs. This can be attributed to the simultaneous disruption of the collagen fibers and water-proteoglycan bonds induced by trypsin digestion. Fatigue loading, on the other hand, primarily influenced the disc's resistance to deformation in a frequency-dependent pattern, where alterations were most noticeable at low loading frequencies. This study confirms the intricate interplay between the biochemical changes induced by enzymatic processes and the mechanical behavior stemming from fatigue loading, suggesting the need for a comprehensive approach to closely mimic the interrelated multifaceted processes of human disc degeneration.

Impact of osteoporosis and Cement-Augmented fusion on adjacent spinal levels Post-Fusion Surgery: Patient-Specific finite element analysis.

Cement-augmentation is a technique commonly used during posterior lumbar instrumented fusion (PLIF) to reinforce compromised osteoporotic vertebral bone, minimize the risk of loosening screws, enhance stability, and improve overall surgical outcomes. In this study, we introduce a novel segmented vertebral body regional modeling approach to investigate the effects of osteoporosis and cement-augmented lumbar fusion on disc biomechanics at spinal levels adjacent to the fused vertebrae. Using our previously validated personalized-poroelastic-osteoligamentous FE model of the spine, fusion was simulated at L4-L5, and the biomechanics of adjacent levels were studied for 30 patients (non-osteoporotic patients (N = 15), osteoporotic patients (N = 15)). PLIF models, with and without cement-augmentation, were developed and compared after an 8 h-rest period (200 N), following a 16 h-cyclic compressive loading of 500-1000 N (40 and 20 min, respectively). Movement in different directions (flexion/ extension/ lateral bending/ axial rotation) was simulated using 10Nm moment before and after cyclic loading. The material mapping algorithm was validated by comparing the results of voxel-based and parametric models. The FE cement-augmented models, subject to daily activity loading, demonstrated significant differences in disc height loss and fluid loss as compared to non-cemented models. The calculated axial stress and fiber strain values were also significantly higher for these models. This work demonstrates that although osteoporosis does not significantly alter the time-dependent characteristics of adjacent IVDs post-surgery, cement-augmentation increases the risk of adjacent segment disease (ASD) incidence. A holistic understanding of the trade-offs and long-term complex interplay between structural reinforcement modalities, including cement augmentation, and altered biomechanics warrants further investigation.

ASIC3 roles in mechanosensitive elongation of nucleus pulposus cells.

Morphological changes of the nucleus pulposus (NP) cells occur concomitantly as part of the intervertebral disc (IVD) degeneration and excessive mechanical loading has been speculated as a significant key factor for contributing to such morphological changes. Therefore, we hypothesize that stress exerted on NP cells can cause a deformity of nucleus in response. The changes of cell morphology is observed in degenerative nucleus pulposus. One of the reasons for degeneration of NP is due to overloading of NP especially in the obese population. So the nucleus deformity caused by stress/force is of our study interest. To delineate the effects and role of mechanical stress, we developed a 3D assay using hydrogel cultures with a circular hole generated with needle indentation to simulate a local stress concentration along the edge of the hole. A stressed zone, encompassing 100 µm of range from the circular edge, is defined based on stress concentration calculation to enable quantitative analysis against the control zone. Our results demonstrated that the circular hole produces stress-induced morphological changes in NP cells. The tangential elongation of NP cells and their nucleus shape changes in the stressed zone are significantly increased compared to the non-stressed control zone. It is proposed that the cell elongation is a direct response to elevated stress within the stressed zone. Subsequently we found the stress induced morphological changes of the NP cells can be significantly reduced by inhibiting ASIC3. This suggests ASIC3 plays an important role of play in mechano-signaling of NP cells.

Biomechanical Investigation of Bone Screw Head Design for Extracting Stripped Screw Heads: Integration of Mechanical Tests and Finite Element Analyses.

Enhancing the design of bone screw head sockets to prevent stripping and improve the torque required for smooth unscrewing is a significant challenge in orthopedic applications. This research aims to establish a quantitative methodology by integrating mechanical testing with finite element (FE) simulations to determine a safe limitation depth for the screwdriver when engaging with the hexagonal socket, thus avoiding stripped screw heads. A FE model was developed to investigate the biomechanical responses of the screw head design. Five custom-made hexagonal sockets were manufactured, and single load torsional tests were conducted to assess the mechanical performance of the screws and drivers. The results from the mechanical tests were compared with the FE simulations, demonstrating a close agreement and confirming the model's validity. Furthermore, additional FE models were created to study the impact of manufacturing tolerances on the socket width and screwdriver width. The findings revealed that the maximum torque to failure for the four designs was lower than the margins specified in ISO 6475. Additionally, increasing the depth of the screwdriver led to higher maximum torque values. This research suggests that the technique of screw insertion, specifically the depth of the driver tool within the screw socket, holds greater importance in preventing stripped screw heads than the design and manufacturing width of the bone screw's hexagonal socket and screwdriver. This confirms the importance of screwdriver engagement inside the bone screw socket to prevent stripped screw heads and sheds light on the added value of maximum torque prediction for future design modifications.

The influence of over-distraction on biomechanical response of cervical spine post anterior interbody fusion: a comprehensive finite element study.

Introduction: Anterior cervical discectomy and fusion (ACDF) has been considered as the gold standard surgical treatment for cervical degenerative pathologies. Some surgeons tend to use larger-sized interbody cages during ACDF to restore the index intervertebral disc height, hence, this study evaluated the effect of larger-sized interbody cages on the cervical spine with ACDF under both static and cyclic loading. Method: Twenty pre-operative personalized poro-hyperelastic finite element (FE) models were developed. ACDF post-operative models were then constructed and four clinical scenarios (i.e., 1) No-distraction; 2) 1 mm distraction; 3) 2 mm distraction; and 4) 3 mm distraction) were predicted for each patient. The biomechanical responses at adjacent spinal levels were studied subject to static and cyclic loading. Non-parametric Friedman statistical comparative tests were performed and the p values less than 0.05 were reflected as significant. Results: The calculated intersegmental range of motion (ROM) and intradiscal pressure (IDP) from 20 pre-operative FE models were within the overall ranges compared to the available data from literature. Under static loading, greater ROM, IDP, facet joint force (FJF) values were detected post ACDF, as compared with pre-op. Over-distraction induced significantly higher IDP and FJF in both upper and lower adjacent levels in extension. Higher annulus fibrosus stress and strain values, and increased disc height and fluid loss at the adjacent levels were observed in ACDF group which significantly increased for over-distraction groups. Discussion: it was concluded that using larger-sized interbody cages (the height of ≥2 mm of the index disc height) can result in remarkable variations in biomechanical responses of adjacent levels, which may indicate as risk factor for adjacent segment disease. The results of this comprehensive FE investigation using personalized modeling technique highlight the importance of selecting the appropriate height of interbody cage in ACDF surgery.

High-Performance Novel MoS2@Zeolite X Nanocomposite-Modified Thin-Film Nanocomposite Forward Osmosis Membranes: A Study of Desalination and Antifouling Performance.

Novel thin-film nanocomposite (TFN) membranes modified by the MoS2@Zeolite X nanocomposite were made and studied for desalination by the forward osmosis (FO) method. Herein, MoS2@Zeolite X nanocomposite (MoS2@Z) and zeolite X particles are integrated into the polyamide (PA) selective layer of the TFN membranes, separately. The aim of this study is the synthesis of nanocomposites containing hydrophilic zeolite X particles with a modified surface and pore and improvement of their effective properties on desalination and antifouling performance. For this purpose, MoS2 nanosheets with a high hydrophilicity were selected. The existence of polymer-matrix-compatible MoS2@Z inside the PA active layer caused the formation of a defect-free smooth surface with further channels within this layer that could increase the water flux and fouling resistance of the TFN membranes. The TFN-MZ2 membrane (containing 0.01 wt % MoS2@Z) showed the top desalination performance in the FO process. In contrast to the pristine thin-film composite (TFC) and TFN-Z2 membrane (containing 0.025 wt % zeolite X, the most optimal membrane among the zeolite-modified membranes), its water flux has increased by 2.6 and 1.8 times, respectively. Furthermore, in the fouling test, this optimal TFN-MZ2 membrane with a flux decrement of 19.6% revealed an ∼2.2- and 1.8-fold enhancement in antifouling tendency compared to the TFC and TFN-Z2, respectively. Also, based on the antibiofouling test, the water flux drop of 48.6% for the TFC membrane has reached 36.9% for the optimal membrane. Hence, this high-performance TFN-MZ2 membrane shows good capability for commercial employment in FO desalination application.

Anatomical parameters alter the biomechanical responses of adjacent segments following lumbar fusion surgery: Personalized poroelastic finite element modelling investigations.

Introduction: While the short-term post-operative outcome of lumbar fusion is satisfying for most patients, adjacent segment disease (ASD) can be prevalent in long-term clinical observations. It might be valuable to investigate if inherent geometrical differences among patients can significantly alter the biomechanics of adjacent levels post-surgery. This study aimed to utilize a validated geometrically personalized poroelastic finite element (FE) modeling technique to evaluate the alteration of biomechanical response in adjacent segments post-fusion. Methods: Thirty patients were categorized for evaluation in this study into two distinct groups [i.e., 1) non-ASD and 2) ASD patients] based on other long-term clinical follow-up investigations. To evaluate the time-dependent responses of the models subjected to cyclic loading, a daily cyclic loading scenario was applied to the FE models. Different rotational movements in different planes were superimposed using a 10 Nm moment after daily loading to compare the rotational motions with those at the beginning of cyclic loading. The biomechanical responses of the lumbosacral FE spine models in both groups were analyzed and compared before and after daily loading. Results: The achieved comparative errors between the FE results and clinical images were on average below 20% and 25% for pre-op and post-op models, respectively, which confirms the applicability of this predictive algorithm for rough pre-planning estimations. The results showed that the disc height loss and fluid loss were increased for the adjacent discs in post-op models after 16 h of cyclic loading. In addition, significant differences in disc height loss and fluid loss were observed between the patients who were in the non-ASD and ASD groups. Similarly, the increased stress and fiber strain in the annulus fibrosus (AF) was higher in the adjacent level of post-op models. However, the calculated stress and fiber strain values were significantly higher for patients with ASD. Discussion: Evaluating the biomechanical response of pre-op and post-op modeling in the non-ASD and ASD groups showed that the inherent geometric differences among patients cause significant variations in the estimated mechanical response. In conclusion, the results of the current study highlighted the effect of geometrical parameters (which may refer to the anatomical conditions or the induced modifications regarding surgical techniques) on time-dependent responses of lumbar spine biomechanics.

Comparative biomechanical analyses of lower cervical spine post anterior fusion versus intervertebral disc arthroplasty: A geometrically patient-specific poroelastic finite element investigation.

Background/Objective: The optimal surgical technique for the treatment of cervical degenerative disc disease (CDDD) towards decreasing the risk of adjacent segment disease (ASD) remains elusive. This study aimed to comparatively investigate the biomechanics of the lower cervical spine following fusion (ACDF) and artificial disc arthroplasty (Bryan® and Prestige LP®) using a validated geometrically patient-specific poroelastic finite element modeling (FEM) approach. Methods: Ten subject-specific pre-operative models were developed and validated based on a FEM approach. Poroelastic models were then constructed using post-operation images for three different treatment scenarios: ACDF; Prestige LP® and Bryan® artificial discs at the C5-C6 level. The biomechanical responses at both surgical and adjacent spinal levels were studied subject to static and cyclic loading. Results: Postoperatively, greater range of motion (ROM), higher annulus fibrosus stress and strain values, and increased disc height and fluid loss at the adjacent levels were detected post ACDF, as compared with pre-op as well as artificial disc arthroplasty. The facet joint forces were larger for the Prestige LP® disc, particularly during extension. The lowest values in disc height and fluid exchange were observed in the Bryan® artificial disc arthroplasty models. Conclusion: Biomechanical analyses revealed that ACDF poses the highest potential risk for adjacent disc degeneration. The artificial discs investigated here (Prestige LP® and Bryan®) not only preserved motion at the instrumented level, but also sustained the pre-op ROM and decreased the intradiscal pressure (IDP) and facet joint forces (FJFs) at adjacent levels, particularly during flexion/extension. The Bryan® artificial disc demonstrated the most efficacy in maintaining the natural poroelastic characteristics of adjacent discs. The translational potential of this article: This study provided a technique for clinicians to use quantitative data towards subject-specific evaluation to comparatively evaluate the impact of ACDF and disc arthroplasty using two types of artificial discs on the biomechanics of the cervical spine. It confirms differences in the poroelastic characteristics of adjacent discs for different fixation techniques, and reveals the advantage of artificial discs with a flexible core for decreasing the risk of ASD.

The effect of orthopedic screw profiles on the healing time of femoral neck fracture.

One possible treatment for femoral neck fractures, especially in young people, is the use of bone screws or Lug screws. The design of these implants requires taking into account the biocompatibility of materials, mechanical properties plus surface properties, and thread's geometric, as well as chemical properties, etc. Various profiles are designed for fracture fixation. The most famous of these profiles, which are introduced by the ISO standard, are HB, HC, and HD type profiles. This article investigates the performance of these profiles in reducing or increasing the healing time. This study is based on the rule of bone remodeling and using a set of three-dimensional computational (finite element) models. The study revealed that the HB profile outperformed the other two profiles. Meanwhile, HD profile was also better than HC profile.

Using different unit-cell geometries to generate bone tissue scaffolds by additive manufacturing technology.

The design and manufacturing three-dimensional scaffolds are a significant concept in bone tissue engineering (BTE). Firstly, from the perspective of manufacturing, Additive manufacturing (AM) technology has achieved great attraction in the field of BTE during the past few years. In the field of BTE, the possibility of generating complex porous structures with high precision compared to typical manufacturing methods has made AM the leading option for scaffold production. Secondly, from the design perspective, design porous scaffold plays a decisive role in BTE since scaffold design with an appropriate architectures have to lead to proper strength and porosity. The purpose of this research is extraction of optimal architecture to achieve maximum mechanical strength of BTE scaffolds. Hence, the geometry structures of the unit-cell have been selected in Cube, Cylinder and Hexagonal prism. On the other hand, for considering the porosity effects, three different unit-cell size have been chosen, and a total of nine scaffolds have been designed. Designed scaffolds were fabricated using Fused Deposition Modeling (FDM) 3D Printer and dimensional features of scaffolds were evaluated by comparing the designed scaffolds with scanning electron microscope (SEM). The specimens were exposed to mechanical compression test and the results were validated with the finite element analysis (FEA). Verified experimental and FEM results offered an excellent possible unit-cell geometry to be applied in design and manufacturing of BTE scaffolds.

Comparative biomechanical analysis of rigid vs. flexible fixation devices for the lumbar spine: A geometrically patient-specific poroelastic finite element study.

BACKGROUND AND OBJECTIVE: Lumbar spinal stenosis (LSS), or the narrowing of the spinal canal, continues to be the leading preoperative diagnosis for adults older than 65 years who undergo spine surgery. Although the treatment of LSS depends on its severity, the optimal surgical technique towards decreasing the risk of adjacent segment disease (ASD) remains elusive. This study aimed to comparatively analyze spinal biomechanics with rigid and flexible fixation devices (i.e., rigid and dynamic posterolateral fusion (PLF) and interspinous process (ISP) devices) during daily activities. METHODS: Using a validated parametric poroelastic finite element modeling approach, 8 subject-specific pre-operative models were developed, and their validity was evaluated. Parametric FE models of the lumbar spines were then regenerated based on post-operation images for (A) rigid PLF (B) dynamic PLF (C) rigid ISP device (Coflex) and (D) flexible ISP device (DIAM) at L4-L5 level. Biomechanical responses for instrumented and adjacent intervertebral discs (IVDs) were analyzed and compared subject to static and cyclic loading. RESULTS: The preoperative models were well comparable with previous works in literature. The postoperative results for the PLF and Coflex rigid systems, demonstrated greater ROM; higher values of stress and strain in the AF region; and increased disc height and fluid loss at the adjacent levels, as compared with the pre-op models and the post-op results of the flexible systems (i.e., dynamic PLF and DIAM). The calculated forces on the facet joint were of smaller magnitude for the ISP devices as compared to the PLF, particularly during extension. CONCLUSIONS: This study demonstrates that the dynamic PLF construct and DIAM implants could be effective to maintain the natural poroelastic characteristics of adjacent IVDs, which could be beneficial for enhancing long-term clinical outcomes. FEM provides clinicians with an invaluable patient-specific quantitative tool for informed surgical planning and discerning follow-up management.

A comparative finite element simulation of locking compression plate materials for tibial fracture treatment.

The locking compression plate (LCP) system has several advantages in fracture fixation combining angular stability with the use of locking screws with traditional fixation techniques. However, the system is complex and requiring careful attention to biomechanical principles and good surgical technique. Due to the set of complicate stresses and strains in the LCP system after implantation, the material, which is being used here, is deemed important. However, so far the materials have been limited to the stainless steel (SS) or titanium (Ti). This study was therefore aimed at investigate the biomechanical performance of the internal tibial locked plates at different material properties, including SS, Ti, carbon/polyether ether ketone (PEEK) composite, in treating medial tibial fracture using patient-specific finite element (FE) model of the human tibia. The carbon/PEEK composite materials were used at three different fiber plies configurations. Simulated loading was applied at 60:40 ratios on the medial:lateral aspect. The model was fixed distally in all degrees of freedom. The results revealed the highest stress (307.10 MPa) and the lowest strain (0.14%) at Ti LCP system. The carbon/PEEK LCP system at configuration I and III showed low stress (∼60 MPa) and high strain (0.70%), which are suitable points for designing of an internal LCP system. On the other hand, the highest value of stress in callus region was 4.78 MPa (Carbon PEEK/Configuration I) and the strain variations of callus region were between 1.46% and 3.82% among all materials. These results implied the advantage of carbon/PEEK composite materials in LCP system as they can tolerate higher strains at lower stresses.

A finite element study of fatigue load effects on total hip joint prosthesis.

The main goal of this study was to perform a fatigue analysis and compare the results for different materials. A 72 years old patient was chosen and his hip radiographic/CT scan images were used to construct the geometry. We used four different material including Titanium, Titanium alloy, Cobalt-Chrome, and Stainless steel. The material characteristics of these prostheses were extracted from the literature. All models were exported to ANSYS software for mathematical analysis and the Von-Mises criteria, deformations, and the fatigue life were calculated for each material. Our findings showed that titanium prosthesis tolerated the lowest stress (i.e., 591 MPa for static, and 687 MPa for fatigue loading) and highest safety factor (i.e., 1.54). We found out that Titanium material could be used as the most appropriate one for the hip prosthesis due to lower stress concentration and longer life compared to other materials.

Biomechanical modeling of spinal ligaments: finite element analysis of L4-L5 spinal segment.

The complex mechanical structure of spine is usually simplified in finite element (FE) modes. In this study, different 3D models of L4-L5 spinal segment distinguished by their ligament modelling were developed (1D truss, 2D shell and 3D space truss elements). All models could be considered validated with respect to range of motion and intradiscal pressure, although their ligament stresses/forces were substantially different. The models with 2D shell and 3D space truss ligaments showed the stress distribution and identified the potential failure/injury locations in ligaments. The model with 3D space truss ligaments showed the stress/force direction (representing collagen fiber directions).

Corrigendum: Biomechanical Investigation Between Rigid and Semirigid Posterolateral Fixation During Daily Activities: Geometrically Parametric Poroelastic Finite Element Analyses.

[This corrects the article DOI: 10.3389/fbioe.2021.646079.].

Biomechanical Investigation Between Rigid and Semirigid Posterolateral Fixation During Daily Activities: Geometrically Parametric Poroelastic Finite Element Analyses.

While spinal fusion using rigid rods remains the gold standard treatment modality for various lumbar degenerative conditions, its adverse effects, including accelerated adjacent segment disease (ASD), are well known. In order to better understand the performance of semirigid constructs using polyetheretherketone (PEEK) in fixation surgeries, the objective of this study was to analyze the biomechanical performance of PEEK versus Ti rods using a geometrically patient-specific poroelastic finite element (FE) analyses. Ten subject-specific preoperative models were developed, and the validity of the models was evaluated with previous studies. Furthermore, FE models of those lumbar spines were regenerated based on postoperation images for posterolateral fixation at the L4-L5 level. Biomechanical responses for instrumented and adjacent intervertebral discs (IVDs) were analyzed and compared subjected to static and cyclic loading. The preoperative model results were well comparable with previous FE studies. The PEEK construct demonstrated a slightly increased range of motion (ROM) at the instrumented level, but decreased ROM at adjacent levels, as compared with the Ti. However, no significant changes were detected during axial rotation. During cyclic loading, disc height loss, fluid loss, axial stress, and collagen fiber strain in the adjacent IVDs were higher for the Ti construct when compared with the intact and PEEK models. Increased ROM, experienced stress in AF, and fiber strain at adjacent levels were observed for the Ti rod group compared with the intact and PEEK rod group, which can indicate the risk of ASD for rigid fixation. Similar to the aforementioned pattern, disc height loss and fluid loss were significantly higher at adjacent levels in the Ti rod group after cycling loading which alter the fluid-solid interaction of the adjacent IVDs. This phenomenon debilitates the damping quality, which results in disc disability in absorbing stress. Such finding may suggest the advantage of using a semirigid fixation system to decrease the chance of ASD.

Biomechanical role of posterior cruciate ligament in total knee arthroplasty: A finite element analysis.

BACKGROUND AND OBJECTIVE: The knee joint is a complex structure which is vulnerable to injury due to various types of loadings as a consequence of walking, running, stair climbing, etc. Total knee arthroplasty (TKA) is a widely used and successful orthopedic procedure which during that the posterior cruciate ligament (PCL) can either be retained or substituted. Different surgical techniques suggest retention or sacrifice of the PCL in TKA for the treatment of osteoarthritis which may alter the post-op outcomes. The objective of this study was to evaluate the biomechanical role of PCL after TKA surgery using finite element (FE) modeling. METHODS: A three-dimensional (3D) FE model of the prosthetic knee was developed and its validity was compared to available studies in literature. Further, the effect of the retention or removing of the PCL as well as its degradation (i.e. variation in mechanical properties) and angle on knee biomechanics were evaluated during a weight-bearing squatting movement. RESULTS: The validity of the intact model were confirmed. The results revealed higher stresses in the PCL and tibial insert at higher femoral flexion angles. In addition, the effect of variations in the stiffness of the PCL was found to be negligible at lower while considerable at higher femoral flexion angles. The variations in the elevation angle of the PCL from 89° to 83° at the critical femoral angles of 60° and 120° showed the highest von Mises stresses in the tibial insert. CONCLUSIONS: The results have implications not only for understanding the stresses in the prosthetic knee model under squat movement but also for providing comprehensive information about the effects of variations in the PCL stiffness and balancing on the induced stresses of the PCL and tibial insert.