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1.
PLoS One ; 7(2): e30350, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22363426

RESUMO

BACKGROUND: We conducted a surveillance study to determine the leading causes of bloodstream infection in febrile patients seeking treatment at three district hospitals in Pemba Island, Zanzibar, Tanzania, an area with low malaria transmission. METHODS: All patients above two months of age presenting to hospital with fever were screened, and blood was collected for microbiologic culture and malaria testing. Bacterial sepsis and malaria crude incidence rates were calculated for a one-year period and were adjusted for study participation and diagnostic sensitivity of blood culture. RESULTS: Blood culture was performed on 2,209 patients. Among them, 166 (8%) samples yielded bacterial growth; 87 (4%) were considered as likely contaminants; and 79 (4%) as pathogenic bacteria. The most frequent pathogenic bacteria isolated were Salmonella Typhi (n = 46; 58%), followed by Streptococcus pneumoniae (n = 12; 15%). The crude bacteremia rate was 6/100,000 but when adjusted for potentially missed cases the rate may be as high as 163/100,000. Crude and adjusted rates for S. Typhi infections and malaria were 4 and 110/100,000 and 4 and 47/100,000, respectively. Twenty three (51%), 22 (49%) and 22 (49%) of the S. Typhi isolates were found to be resistant toward ampicillin, chloramphenicol and cotrimoxazole, respectively. Multidrug resistance (MDR) against the three antimicrobials was detected in 42% of the isolates. CONCLUSIONS: In the presence of very low malaria incidence we found high rates of S. Typhi and S. pneumoniae infections on Pemba Island, Zanzibar. Preventive measures such as vaccination could reduce the febrile disease burden.


Assuntos
Bacteriemia/epidemiologia , Infecções Bacterianas/epidemiologia , Infecções Bacterianas/microbiologia , Adolescente , Adulto , Distribuição por Idade , Antibacterianos/farmacologia , Bacteriemia/complicações , Bacteriemia/microbiologia , Bactérias/efeitos dos fármacos , Infecções Bacterianas/complicações , Criança , Pré-Escolar , Geografia , Hospitais/estatística & dados numéricos , Humanos , Incidência , Malária/complicações , Malária/epidemiologia , Testes de Sensibilidade Microbiana , Tanzânia/epidemiologia
2.
PLoS One ; 7(12): e51823, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23284780

RESUMO

BACKGROUND: The gold standard for diagnosis of typhoid fever is blood culture (BC). Because blood culture is often not available in impoverished settings it would be helpful to have alternative diagnostic approaches. We therefore investigated the usefulness of clinical signs, WHO case definition and Widal test for the diagnosis of typhoid fever. METHODOLOGY/PRINCIPAL FINDINGS: Participants with a body temperature ≥37.5°C or a history of fever were enrolled over 17 to 22 months in three hospitals on Pemba Island, Tanzania. Clinical signs and symptoms of participants upon presentation as well as blood and serum for BC and Widal testing were collected. Clinical signs and symptoms of typhoid fever cases were compared to other cases of invasive bacterial diseases and BC negative participants. The relationship of typhoid fever cases with rainfall, temperature, and religious festivals was explored. The performance of the WHO case definitions for suspected and probable typhoid fever and a local cut off titre for the Widal test was assessed. 79 of 2209 participants had invasive bacterial disease. 46 isolates were identified as typhoid fever. Apart from a longer duration of fever prior to admission clinical signs and symptoms were not significantly different among patients with typhoid fever than from other febrile patients. We did not detect any significant seasonal patterns nor correlation with rainfall or festivals. The sensitivity and specificity of the WHO case definition for suspected and probable typhoid fever were 82.6% and 41.3% and 36.3 and 99.7% respectively. Sensitivity and specificity of the Widal test was 47.8% and 99.4 both forfor O-agglutinin and H- agglutinin at a cut-off titre of 1:80. CONCLUSIONS/SIGNIFICANCE: Typhoid fever prevalence rates on Pemba are high and its clinical signs and symptoms are non-specific. The sensitivity of the Widal test is low and the WHO case definition performed better than the Widal test.


Assuntos
Salmonella typhi/isolamento & purificação , Febre Tifoide/diagnóstico , Febre Tifoide/epidemiologia , Organização Mundial da Saúde , Adolescente , Adulto , Testes de Aglutinação , Criança , Pré-Escolar , Feminino , Hospitais , Humanos , Ilhas do Oceano Índico/epidemiologia , Lactente , Masculino , Pessoa de Meia-Idade , Probabilidade , Sensibilidade e Especificidade , Tanzânia/epidemiologia , Adulto Jovem
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