Insect pest management in the age of synthetic biology.

Arthropod crop pests are responsible for 20% of global annual crop losses, a figure predicted to increase in a changing climate where the ranges of numerous species are projected to expand. At the same time, many insect species are beneficial, acting as pollinators and predators of pest species. For thousands of years, humans have used increasingly sophisticated chemical formulations to control insect pests but, as the scale of agriculture expanded to meet the needs of the global population, concerns about the negative impacts of agricultural practices on biodiversity have grown. While biological solutions, such as biological control agents and pheromones, have previously had relatively minor roles in pest management, biotechnology has opened the door to numerous new approaches for controlling insect pests. In this review, we look at how advances in synthetic biology and biotechnology are providing new options for pest control. We discuss emerging technologies for engineering resistant crops and insect populations and examine advances in biomanufacturing that are enabling the production of new products for pest control.

Im Blickwinkel der Technik: Neue Verhältnisse von Wissenschaftstheorie und Wissenschaftsgeschichte.

Changing Perspectives - From the Experimental to the Technological Turn in History and Philosophy of Science. In the 1960s the philosophy of science was transformed through the encounter with the history of science, resulting in a collaborative venture by the name of "History and Philosophy of Science" (HPS). Philosophy of science adopted ever more regularly the format of the case study to reconstruct certain episodes from the history of science, and historians were mostly interested in the production of scientific knowledge. The so-called "experimental turn" of the 1980s owed to this interaction between philosophy and history. Its guiding question remained quite traditional, however, namely "How do the sciences achieve an agreement between representation and reality?" Only the answers to this question broke with tradition by focusing not on theory but on the role of instruments and experiments. - Roughly 30 years after the experimental turn, another transformative encounter appears to be taking place. HPS is being transformed in the encounter with philosophy of technology. From the point of view of philosophy of technology, the question does not arise whether and how the agreement of mind and world, representation and reality can be achieved. When things are constructed, built or made, human thinking and physical materiality are inseparably intertwined. Instead of seeking to describe a mind-independent reality, technoscientific researchers are working to acquire and demonstrate capabilities of experimental or predictive control. When science is regarded as a kind of technology, a program of study opens up for epistemology and so do avenues for the historiography of science. History of science might now show how the problems and procedures of the sciences arise from and impinge back upon a world that is itself a product of science and technology. It thereby abandons its traditional HPS niche existence and joins forces with environmental history, history of technology, social, labor, and consumer history.

Knots and strands: an argument for productive disillusionment.

This article offers a contrast between European and US-American approaches to the convergence of enabling technologies and to associated issues. It identifies an apparently paradoxical situation in which regional differences produce conflicting claims to universality, each telling us what can and will happen to the benefit of humanity. Those who might mediate and negotiate these competing claims are themselves entangled in the various positions. A possible solution is offered, namely a universalizable strategy that aims to disentangle premature claims to unity and universality as in the case of the greater "efficiency" of nanomedicine. This is the strategy by which Science and Technologies Studies (STS) can analytically tease apart what it has helped produce and sustain in the first place. The virtues and limits of this strategy are briefly presented, deliberation and decision-making under conditions of productive disillusionment recommended.