Detalhe da pesquisa
1.
A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.
J Biol Chem
; 293(3): 941-952, 2018 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29180448
2.
Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.
J Biol Chem
; 292(35): 14401-14412, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28705932
3.
Pegloticase co-administered with high MW polyethylene glycol effectively reduces PEG-immunogenicity and restores prolonged circulation in mouse.
Acta Biomater
; 170: 250-259, 2023 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37659730
4.
Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk.
PLoS One
; 18(9): e0291330, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37682977
5.
Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis.
MAbs
; 15(1): 2209920, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37184136
6.
High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies.
J Control Release
; 338: 804-812, 2021 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34481925
7.
Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.
FASEB J
; 20(10): 1671-9, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16873890
8.
Evidence for a synergistic salt-protein interaction -- complex patterns of activation vs. inhibition of nitrogenase by salt.
Biophys Chem
; 122(3): 184-94, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16603308
9.
Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells.
Cell Mol Immunol
; 13(3): 391-400, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25942513
10.
A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties.
PLoS One
; 11(12): e0167935, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002433
11.
Overexpression of nicastrin increases Abeta production.
FASEB J
; 17(9): 1138-40, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12692078
12.
In vivo and ex vivo imaging of amyloid-ß cascade aggregates with a Pronucleon™ peptide.
J Alzheimers Dis
; 34(4): 957-67, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23321523
13.
Targeting the junction of CÉmX and É-migis for the specific depletion of mIgE-expressing B cells.
Mol Immunol
; 52(3-4): 279-88, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22750228
14.
C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
J Neurochem
; 96(1): 218-27, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16305624
15.
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates.
Mol Neurodegener
; 1: 3, 2006 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16930450
16.
Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.
Biochem Biophys Res Commun
; 340(2): 668-74, 2006 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16376853
17.
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.
Biochemistry
; 45(28): 8649-56, 2006 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-16834339
18.
Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.
Mol Neurodegener
; 1: 16, 2006 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17105660
19.
Flavodoxin hydroquinone reduces Azotobacter vinelandii Fe protein to the all-ferrous redox state with a S = 0 spin state.
Proc Natl Acad Sci U S A
; 103(46): 17131-6, 2006 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17085583
20.
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin.
J Biol Chem
; 279(41): 43148-56, 2004 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15252014