miR-378-3p Knockdown Recapitulates Many of the Features of Myelodysplastic Syndromes.

Myelodysplastic syndromes (MDS) are clonal neoplasms of the hematopoietic stem cell that result in aberrant differentiation of hematopoietic lineages caused by a wide range of underlying genetic, epigenetic, and other causes. Despite the myriad origins, a recognizable MDS phenotype has been associated with miRNA aberrant expression. A model of aberrant myeloid maturation that mimics MDS was generated using a stable knockdown of miR-378-3p. This model exhibited a transcriptional profile indicating aberrant maturation and function, immunophenotypic and morphologic dysplasia, and aberrant growth that characterizes MDS. Moreover, aberrant signal transduction in response to stimulation specific to the stage of myeloid maturation as indicated by CyTOF mass cytometry was similar to that found in samples from patients with MDS. The aberrant signaling, immunophenotypic changes, cellular growth, and colony formation ability seen in this myeloid model could be reversed with azacytidine, albeit without significant improvement of neutrophil function.

Maternal gestures with 20-month-old infants in two contexts.

Speech directed towards young children ("motherese") is subject to consistent systematic modifications. Recent research suggests that gesture directed towards young children is similarly modified (gesturese). It has been suggested that gesturese supports speech, therefore scaffolding communicative development (the facilitative interactional theory). Alternatively, maternal gestural modification may be a consequence of the semantic simplicity of interaction with infants (the interactional artefact theory). The gesture patterns of 12 English mothers were observed with their 20-month-old infants while engaged in two tasks, free play and a counting task, designed to differentially tap into scaffolding. Gestures accounted for 29% of total maternal communicative behaviour. English mothers employed mainly concrete deictic gestures (e.g. pointing) that supported speech by disambiguating and emphasizing the verbal utterance. Maternal gesture rate and informational gesture-speech relationship were consistent across tasks, supporting the interactional artefact theory. This distinctive pattern of gesture use for the English mothers was similar to that reported for American and Italian mothers, providing support for universality. Child-directed gestures are not redundant in relation to child-directed speech but rather both are used by mothers to support their communicative acts with infants.

Coder Educator: The Way Forward.

The introduction of a new Coder Educator position in the Coding Unit at the Princess Alexandra Hospital, Brisbane, Queensland, has been a key strategy in the development and maintenance of a skilled coding workforce, the improvement of the level of knowledge of the coding staff, and the provision of a career structure for clinical coders. In this report, the experience is related from the perspectives of the Coding Manager and the Coder Educator.

Saúde Amanhã: Textos para Discussão 75: Concentração e Dispersão Urbana: o que nos reserva o futuro próximo?

O artigo em pauta tem por finalidade proceder a uma análise das principais tendências de crescimento e seus consequentes impactos nas Concentrações Urbanas brasileiras, em particular os que se referem ao saneamento básico. O estudo se apoia nos referenciais analíticos e espaciais dos Arranjos Populacionais e as Concentrações Urbanas do Brasil (IBGE, 2016) e da pesquisa REGIC 2018 - Regiões de Influência das Cidades (IBGE, 2020a).

Saúde Amanhã: Textos para Discussão 45: Dinâmica Demográfica e Distribuição Espacial da População: cenários para 2040, um olhar socioeconômico

O desafio agora é elaborar cenários demográfico e socioeconômico em meio a uma pandemia, num quadro de manutenção de níveis elevados de expansão do contágio e das mortes, o que não é exercício dos mais simples. Na dimensão sanitária, a situação é ainda mais grave devido à necropolítica praticada pelo governo central e pelas vacilações dos governantes locais ante à pressão das elites para que sejam retomadas as atividades econômicas.

Saúde Amanhã: Textos para Discussão 31: Distribuição Espacial Da População E Dos Serviços De Saúde: as regiões de articulação urbana

O presente artigo possui o objetivo de avaliar a relação entre a quantidade de equipamentos/ procedimentos de saúde do Sistema Único de Saúde (SUS) e a distribuição da população no Brasil. Como unidade espacial de análise, recorre-se às Regiões de Articulação Urbana em suas três escalas: Imediata, Intermediária e Ampliada. Assim, o trabalho é estruturado a partir de leituras interescalares dos temas abordados, indicando-se ao final quais áreas do país possuem carências no recobrimento dos equipamentos/procedimentos selecionados.