Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Immunology Lessons from the SARS-CoV-2 Pandemic.

Yokoyama, Wayne M; Hogquist, Kristin A; O'Shea, John J.

Annu Rev Immunol ; 39: v-vii, 2021 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-33939926

2.

The JAK-STAT pathway at 30: Much learned, much more to do.

Philips, Rachael L; Wang, Yuxin; Cheon, HyeonJoo; Kanno, Yuka; Gadina, Massimo; Sartorelli, Vittorio; Horvath, Curt M; Darnell, James E; Stark, George R; O'Shea, John J.

Cell ; 185(21): 3857-3876, 2022 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-36240739

3.

Microbial ligand-independent regulation of lymphopoiesis by NOD1.

Iwamura, Chiaki; Ohnuki, Hidetaka; Flomerfelt, Francis A; Zheng, Lixin; Carletti, Alexie; Wakashin, Hidefumi; Mikami, Yohei; Brooks, Stephen R; Kanno, Yuka; Gress, Ronald E; Tosato, Giovanna; Nakayama, Toshinori; O'Shea, John J; Sher, Alan; Jankovic, Dragana.

Nat Immunol ; 24(12): 2080-2090, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-37957354

4.

Transcription factor EGR2 controls homing and pathogenicity of T_H17 cells in the central nervous system.

Gao, Yuanyuan; Wang, Yan; Chauss, Daniel; Villarino, Alejandro V; Link, Verena M; Nagashima, Hiroyuki; Spinner, Camille A; Koparde, Vishal N; Bouladoux, Nicolas; Abers, Michael S; Break, Timothy J; Chopp, Laura B; Park, Jung-Hyun; Zhu, Jinfang; Wiest, David L; Leonard, Warren J; Lionakis, Michail S; O'Shea, John J; Afzali, Behdad; Belkaid, Yasmine; Lazarevic, Vanja.

Nat Immunol ; 24(8): 1331-1344, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37443284

5.

SnapShot: Jak-STAT Signaling II.

Villarino, Alejandro V; Gadina, Massimo; O'Shea, John J; Kanno, Yuka.

Cell ; 181(7): 1696-1696.e1, 2020 06 25.

Artigo em Inglês | MEDLINE | ID: mdl-32589961

6.

Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.

Kanno, Yuka; Vahedi, Golnaz; Hirahara, Kiyoshi; Singleton, Kentner; O'Shea, John J.

Annu Rev Immunol ; 30: 707-31, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22224760

7.

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells.

Yao, Chen; Lou, Guohua; Sun, Hong-Wei; Zhu, Ziang; Sun, Yi; Chen, Zeyu; Chauss, Daniel; Moseman, E Ashley; Cheng, Jun; D'Antonio, Marc A; Shi, Wangke; Shi, Junwei; Kometani, Kohei; Kurosaki, Tomohiro; Wherry, E John; Afzali, Behdad; Gattinoni, Luca; Zhu, Yuwen; McGavern, Dorian B; O'Shea, John J; Schwartzberg, Pamela L; Wu, Tuoqi.

Nat Immunol ; 22(3): 370-380, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33574619

8.

A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification.

Liu, Chunhong; Nagashima, Hiroyuki; Fernando, Nilisha; Bass, Victor; Gopalakrishnan, Jaanam; Signorella, Sadie; Montgomery, Will; Lim, Ai Ing; Harrison, Oliver; Reich, Lauren; Yao, Chen; Sun, Hong-Wei; Brooks, Stephen R; Jiang, Kan; Nagarajan, Vijayaraj; Zhao, Yongbing; Jung, Seolkyoung; Phillips, Rachael; Mikami, Yohei; Lareau, Caleb A; Kanno, Yuka; Jankovic, Dragana; Aryee, Martin J; Pekowska, Aleksandra; Belkaid, Yasmine; O'Shea, John; Shih, Han-Yu.

Immunity ; 57(5): 1005-1018.e7, 2024 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-38697116

9.

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.

Linehan, Jonathan L; Harrison, Oliver J; Han, Seong-Ji; Byrd, Allyson L; Vujkovic-Cvijin, Ivan; Villarino, Alejandro V; Sen, Shurjo K; Shaik, Jahangheer; Smelkinson, Margery; Tamoutounour, Samira; Collins, Nicholas; Bouladoux, Nicolas; Dzutsev, Amiran; Rosshart, Stephan P; Arbuckle, Jesse H; Wang, Chyung-Ru; Kristie, Thomas M; Rehermann, Barbara; Trinchieri, Giorgio; Brenchley, Jason M; O'Shea, John J; Belkaid, Yasmine.

Cell ; 172(4): 784-796.e18, 2018 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-29358051

10.

Single-cell RNA-seq reveals TOX as a key regulator of CD8⁺ T cell persistence in chronic infection.

Yao, Chen; Sun, Hong-Wei; Lacey, Neal E; Ji, Yun; Moseman, E Ashley; Shih, Han-Yu; Heuston, Elisabeth F; Kirby, Martha; Anderson, Stacie; Cheng, Jun; Khan, Omar; Handon, Robin; Reilley, Julie; Fioravanti, Jessica; Hu, Jinhui; Gossa, Selamawit; Wherry, E John; Gattinoni, Luca; McGavern, Dorian B; O'Shea, John J; Schwartzberg, Pamela L; Wu, Tuoqi.

Nat Immunol ; 20(7): 890-901, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31209400

11.

Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality.

Shih, Han-Yu; Sciumè, Giuseppe; Mikami, Yohei; Guo, Liying; Sun, Hong-Wei; Brooks, Stephen R; Urban, Joseph F; Davis, Fred P; Kanno, Yuka; O'Shea, John J.

Cell ; 165(5): 1120-1133, 2016 May 19.

Artigo em Inglês | MEDLINE | ID: mdl-27156451

12.

MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23.

Mikami, Yohei; Philips, Rachael L; Sciumè, Giuseppe; Petermann, Franziska; Meylan, Françoise; Nagashima, Hiroyuki; Yao, Chen; Davis, Fred P; Brooks, Stephen R; Sun, Hong-Wei; Takahashi, Hayato; Poholek, Amanda C; Shih, Han-Yu; Afzali, Behdad; Muljo, Stefan A; Hafner, Markus; Kanno, Yuka; O'Shea, John J.

Immunity ; 54(3): 514-525.e6, 2021 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-33657395

13.

A Metabolic Switch for Th17 Pathogenicity.

Davis, Fred P; Kanno, Yuka; O'Shea, John J.

Cell ; 163(6): 1308-10, 2015 Dec 03.

Artigo em Inglês | MEDLINE | ID: mdl-26638065

14.

Mechanisms and consequences of Jak-STAT signaling in the immune system.

Villarino, Alejandro V; Kanno, Yuka; O'Shea, John J.

Nat Immunol ; 18(4): 374-384, 2017 03 22.

Artigo em Inglês | MEDLINE | ID: mdl-28323260

15.

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali, Behdad; Grönholm, Juha; Vandrovcova, Jana; O'Brien, Charlotte; Sun, Hong-Wei; Vanderleyden, Ine; Davis, Fred P; Khoder, Ahmad; Zhang, Yu; Hegazy, Ahmed N; Villarino, Alejandro V; Palmer, Ira W; Kaufman, Joshua; Watts, Norman R; Kazemian, Majid; Kamenyeva, Olena; Keith, Julia; Sayed, Anwar; Kasperaviciute, Dalia; Mueller, Michael; Hughes, Jason D; Fuss, Ivan J; Sadiyah, Mohammed F; Montgomery-Recht, Kim; McElwee, Joshua; Restifo, Nicholas P; Strober, Warren; Linterman, Michelle A; Wingfield, Paul T; Uhlig, Holm H; Roychoudhuri, Rahul; Aitman, Timothy J; Kelleher, Peter; Lenardo, Michael J; O'Shea, John J; Cooper, Nichola; Laurence, Arian D J.

Nat Immunol ; 18(7): 813-823, 2017 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-28530713

16.

Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells.

Sciumè, Giuseppe; Mikami, Yohei; Jankovic, Dragana; Nagashima, Hiroyuki; Villarino, Alejandro V; Morrison, Tasha; Yao, Chen; Signorella, Sadie; Sun, Hong-Wei; Brooks, Stephen R; Fang, Difeng; Sartorelli, Vittorio; Nakayamada, Shingo; Hirahara, Kiyoshi; Zitti, Beatrice; Davis, Fred P; Kanno, Yuka; O'Shea, John J; Shih, Han-Yu.

Immunity ; 53(4): 745-758.e4, 2020 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-33010223

17.

In search of magic bullets: the golden age of immunotherapeutics.

O'Shea, John J; Kanno, Yuka; Chan, Andrew C.

Cell ; 157(1): 227-40, 2014 Mar 27.

Artigo em Inglês | MEDLINE | ID: mdl-24679538

18.

Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells.

Yao, Chen; Lou, Guohua; Sun, Hong-Wei; Zhu, Ziang; Sun, Yi; Chen, Zeyu; Chauss, Daniel; Moseman, E Ashley; Cheng, Jun; D'Antonio, Marc A; Shi, Wangke; Shi, Junwei; Kometani, Kohei; Kurosaki, Tomohiro; Wherry, E John; Afzali, Behdad; Gattinoni, Luca; Zhu, Yuwen; McGavern, Dorian B; O'Shea, John J; Schwartzberg, Pamela L; Wu, Tuoqi.

Nat Immunol ; 22(4): 530, 2021 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-33658708

19.

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.

Roychoudhuri, Rahul; Clever, David; Li, Peng; Wakabayashi, Yoshiyuki; Quinn, Kylie M; Klebanoff, Christopher A; Ji, Yun; Sukumar, Madhusudhanan; Eil, Robert L; Yu, Zhiya; Spolski, Rosanne; Palmer, Douglas C; Pan, Jenny H; Patel, Shashank J; Macallan, Derek C; Fabozzi, Giulia; Shih, Han-Yu; Kanno, Yuka; Muto, Akihiko; Zhu, Jun; Gattinoni, Luca; O'Shea, John J; Okkenhaug, Klaus; Igarashi, Kazuhiko; Leonard, Warren J; Restifo, Nicholas P.

Nat Immunol ; 17(7): 851-860, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27158840

20.

The Î³_c Family of Cytokines: Basic Biology to Therapeutic Ramifications.

Leonard, Warren J; Lin, Jian-Xin; O'Shea, John J.

Immunity ; 50(4): 832-850, 2019 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-30995502

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