RESUMO
OBJECTIVE: We previously demonstrated that sustained inflation (SI) during chest compression (CC) significantly reduces time to return of spontaneous circulation (ROSC) when compared to 3:1 compression:ventilation (C:V) ratio during neonatal resuscitation. However, the optimal length of SI during CC to improve ROSC and hemodynamic recovery in severely asphyxiated piglets is unknown. AIM: To examine if different lengths of SI will improve ROSC and hemodynamic recovery in severely asphyxiated piglets. INTERVENTION AND MEASUREMENTS: Thirty newborn piglets (1-3 days) were anesthetized, intubated, instrumented and exposed to 30-min normocapnic hypoxia followed by asphyxia. Piglets were randomized into four groups: 3:1 C:V (nâ¯=â¯8), CC with an SI duration of either 20â¯s (CC+SI 20) (nâ¯=â¯8) or 60â¯s (CC+SI 60) (nâ¯=â¯8), and a sham group (nâ¯=â¯6). Cardiac function, carotid blood flow, cerebral and renal oxygenation as well as respiratory parameters were continuously recorded throughout the experiment. MAIN RESULTS: When compared with 3:1 group, both CC+SI 20 and CC+SI 60 groups had significantly shorter ROSC time (pâ¯=â¯0.002). All three intervention groups had similar hemodynamic recovery by the end of 4â¯h observation period. There was no difference in lung injury markers among all experimental groups. However, when compared to the sham group, the concentrations of IL-6 (thalamus) and IL-6â¯+â¯IL-8 (frontoparietal cortex) of the 3:1 C:V group were significantly higher, respectively. CONCLUSIONS: Even though relatively less animals achieved ROSC, CC during SI significantly improved ROSC time compared to 3:1 C:V in asphyxiated newborn piglets. However, there was no difference in ROSC characteristics and hemodynamic recovery between two CC+SI groups.