Detalhe da pesquisa
1.
Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells.
J Neurooncol
; 166(1): 99-112, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38184819
2.
Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines.
J Neurooncol
; 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38630384
3.
Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells.
J Neurooncol
; 164(3): 617-632, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37783879
4.
Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow.
J Neurooncol
; 165(3): 467-478, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37999877
5.
Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells.
J Neurooncol
; 163(1): 143-158, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-37183219
6.
Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
J Am Chem Soc
; 144(41): 18861-18875, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36200994
7.
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.
Chembiochem
; 23(14): e202200180, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35608330
8.
iTReX: Interactive exploration of mono- and combination therapy dose response profiling data.
Pharmacol Res
; 175: 105996, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34848323
9.
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.
Int J Mol Sci
; 23(14)2022 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35886887
10.
The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines.
Arch Toxicol
; 92(8): 2649-2664, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29947893
11.
Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1ß via a Caspase-1-Independent Mechanism.
J Immunol
; 195(11): 5421-31, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26519528
12.
Histone deacetylase 10 promotes autophagy-mediated cell survival.
Proc Natl Acad Sci U S A
; 110(28): E2592-601, 2013 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23801752
13.
Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells.
Blood
; 122(5): 684-93, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23801635
14.
MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma.
Nucleic Acids Res
; 41(12): 6018-33, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23625969
15.
HDAC11 is a novel drug target in carcinomas.
Int J Cancer
; 132(9): 2200-8, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23024001
16.
Evaluation of Antitumor and On-Target Activity of HDAC Inhibitors with the Zebrafish Embryo Xenograft Model.
Methods Mol Biol
; 2589: 75-85, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36255618
17.
Synthesis, Biochemical, and Cellular Evaluation of HDAC6 Targeting Proteolysis Targeting Chimeras.
Methods Mol Biol
; 2589: 179-193, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36255625
18.
ERBB and P-glycoprotein inhibitors break resistance in relapsed neuroblastoma models through P-glycoprotein.
Mol Oncol
; 17(1): 37-58, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36181342
19.
Key Pharmacokinetic Parameters of 74 Pediatric Anticancer Drugs Providing Assistance in Preclinical Studies.
Clin Pharmacol Ther
; 114(4): 904-913, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37441736
20.
The first-in-class ERK inhibitor ulixertinib shows promising activity in mitogen-activated protein kinase (MAPK)-driven pediatric low-grade glioma models.
Neuro Oncol
; 25(3): 566-579, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35882450