Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Intratumoral CD4⁺ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer.

Oh, David Y; Kwek, Serena S; Raju, Siddharth S; Li, Tony; McCarthy, Elizabeth; Chow, Eric; Aran, Dvir; Ilano, Arielle; Pai, Chien-Chun Steven; Rancan, Chiara; Allaire, Kathryn; Burra, Arun; Sun, Yang; Spitzer, Matthew H; Mangul, Serghei; Porten, Sima; Meng, Maxwell V; Friedlander, Terence W; Ye, Chun Jimmie; Fong, Lawrence.

Cell ; 181(7): 1612-1625.e13, 2020 06 25.

Artigo em Inglês | MEDLINE | ID: mdl-32497499

2.

Cytotoxic CD4⁺ T cells in cancer: Expanding the immune effector toolbox.

Oh, David Y; Fong, Lawrence.

Immunity ; 54(12): 2701-2711, 2021 12 14.

Artigo em Inglês | MEDLINE | ID: mdl-34910940

3.

Non-viral precision T cell receptor replacement for personalized cell therapy.

Foy, Susan P; Jacoby, Kyle; Bota, Daniela A; Hunter, Theresa; Pan, Zheng; Stawiski, Eric; Ma, Yan; Lu, William; Peng, Songming; Wang, Clifford L; Yuen, Benjamin; Dalmas, Olivier; Heeringa, Katharine; Sennino, Barbara; Conroy, Andy; Bethune, Michael T; Mende, Ines; White, William; Kukreja, Monica; Gunturu, Swetha; Humphrey, Emily; Hussaini, Adeel; An, Duo; Litterman, Adam J; Quach, Boi Bryant; Ng, Alphonsus H C; Lu, Yue; Smith, Chad; Campbell, Katie M; Anaya, Daniel; Skrdlant, Lindsey; Huang, Eva Yi-Hsuan; Mendoza, Ventura; Mathur, Jyoti; Dengler, Luke; Purandare, Bhamini; Moot, Robert; Yi, Michael C; Funke, Roel; Sibley, Alison; Stallings-Schmitt, Todd; Oh, David Y; Chmielowski, Bartosz; Abedi, Mehrdad; Yuan, Yuan; Sosman, Jeffrey A; Lee, Sylvia M; Schoenfeld, Adam J; Baltimore, David; Heath, James R.

Nature ; 615(7953): 687-696, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36356599

4.

Clonal Deletion of Tumor-Specific T Cells by Interferon-Î³ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.

Pai, Chien-Chun Steven; Huang, John T; Lu, Xiaoqing; Simons, Donald M; Park, Chanhyuk; Chang, Anthony; Tamaki, Whitney; Liu, Eric; Roybal, Kole T; Seagal, Jane; Chen, Mingyi; Hagihara, Katsunobu; Wei, Xiao X; DuPage, Michel; Kwek, Serena S; Oh, David Y; Daud, Adil; Tsai, Katy K; Wu, Clint; Zhang, Li; Fasso, Marcella; Sachidanandam, Ravi; Jayaprakash, Anitha; Lin, Ingrid; Casbon, Amy-Jo; Kinsbury, Gillian A; Fong, Lawrence.

Immunity ; 50(2): 477-492.e8, 2019 02 19.

Artigo em Inglês | MEDLINE | ID: mdl-30737146

5.

Immunity in the Time of Metastases.

Oh, David Y; Fong, Lawrence.

Immunity ; 49(6): 1002-1003, 2018 12 18.

Artigo em Inglês | MEDLINE | ID: mdl-30566878

6.

Early changes in the circulating T cells are associated with clinical outcomes after PD-L1 blockade by durvalumab in advanced NSCLC patients.

Naidus, Elliot; Bouquet, Jerome; Oh, David Y; Looney, Timothy J; Yang, Hai; Fong, Lawrence; Standifer, Nathan E; Zhang, Li.

Cancer Immunol Immunother ; 70(7): 2095-2102, 2021 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-33420629

7.

Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors.

Baik, Alan H; Tsai, Katy K; Oh, David Y; Aras, Mandar A.

Clin Sci (Lond) ; 135(5): 703-724, 2021 03 12.

Artigo em Inglês | MEDLINE | ID: mdl-33686402

8.

Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes.

Ehrlich, Lauren I Richie; Oh, David Y; Weissman, Irving L; Lewis, Richard S.

Immunity ; 31(6): 986-98, 2009 Dec 18.

Artigo em Inglês | MEDLINE | ID: mdl-19962328

9.

On the Verge: Immunotherapy for Colorectal Carcinoma.

Oh, David Y; Venook, Alan P; Fong, Lawrence.

J Natl Compr Canc Netw ; 13(8): 970-8, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-26285242

10.

Balancing the Checkpoint: Managing Colitis Associated with Dual Checkpoint Inhibitors and High-Dose Aspirin.

Hammami, Muhammad B; Gill, Ryan; Thiruvengadam, Nikhil; Oh, David Y; Beck, Kendall; Mahadevan, Uma; Kattah, Michael G.

Dig Dis Sci ; 64(3): 685-688, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30778872

11.

Dysregulation of CD4⁺ and CD8⁺ resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis.

He, Jun Yan; Kim, Yang-Joon; Mennillo, Elvira; Rusu, Iulia; Bain, Jared; Rao, Arjun A; Andersen, Christopher; Law, Karen; Yang, Hai; Tsui, Jessica; Shen, Alan; Davidson, Brittany; Kushnoor, Divyashree; Shi, Yimin; Fan, Frances; Cheung, Alexander; Zhang, Li; Fong, Lawrence; Combes, Alexis J; Pisco, Angela O; Kattah, Michael G; Oh, David Y.

J Immunother Cancer ; 12(4)2024 Apr 19.

Artigo em Inglês | MEDLINE | ID: mdl-38642938

12.

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis.

Mennillo, Elvira; Kim, Yang Joon; Lee, Gyehyun; Rusu, Iulia; Patel, Ravi K; Dorman, Leah C; Flynn, Emily; Li, Stephanie; Bain, Jared L; Andersen, Christopher; Rao, Arjun; Tamaki, Stanley; Tsui, Jessica; Shen, Alan; Lotstein, Madison L; Rahim, Maha; Naser, Mohammad; Bernard-Vazquez, Faviola; Eckalbar, Walter; Cho, Soo-Jin; Beck, Kendall; El-Nachef, Najwa; Lewin, Sara; Selvig, Daniel R; Terdiman, Jonathan P; Mahadevan, Uma; Oh, David Y; Fragiadakis, Gabriela K; Pisco, Angela; Combes, Alexis J; Kattah, Michael G.

bioRxiv ; 2024 Jan 03.

Artigo em Inglês | MEDLINE | ID: mdl-36711576

13.

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis.

Mennillo, Elvira; Kim, Yang Joon; Lee, Gyehyun; Rusu, Iulia; Patel, Ravi K; Dorman, Leah C; Flynn, Emily; Li, Stephanie; Bain, Jared L; Andersen, Christopher; Rao, Arjun; Tamaki, Stanley; Tsui, Jessica; Shen, Alan; Lotstein, Madison L; Rahim, Maha; Naser, Mohammad; Bernard-Vazquez, Faviola; Eckalbar, Walter; Cho, Soo-Jin; Beck, Kendall; El-Nachef, Najwa; Lewin, Sara; Selvig, Daniel R; Terdiman, Jonathan P; Mahadevan, Uma; Oh, David Y; Fragiadakis, Gabriela K; Pisco, Angela; Combes, Alexis J; Kattah, Michael G.

Nat Commun ; 15(1): 1493, 2024 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-38374043

14.

Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results.

Hassan, Raffit; Butler, Marcus; O'Cearbhaill, Roisin E; Oh, David Y; Johnson, Melissa; Zikaras, Kevin; Smalley, Munisha; Ross, Michael; Tanyi, Janos L; Ghafoor, Azam; Shah, Nirali N; Saboury, Babak; Cao, Liang; Quintás-Cardama, Alfonso; Hong, David.

Nat Med ; 29(8): 2099-2109, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37501016

15.

Preparation of Radiolabeled Antibodies for Nuclear Medicine Applications in Immuno-Oncology.

Wei, Junnian; Oh, David Y; Evans, Michael J.

Methods Mol Biol ; 2393: 829-839, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-34837214

16.

Androgen conspires with the CD8⁺ T cell exhaustion program and contributes to sex bias in cancer.

Kwon, Hyunwoo; Schafer, Johanna M; Song, No-Joon; Kaneko, Satoshi; Li, Anqi; Xiao, Tong; Ma, Anjun; Allen, Carter; Das, Komal; Zhou, Lei; Riesenberg, Brian; Chang, Yuzhou; Weltge, Payton; Velegraki, Maria; Oh, David Y; Fong, Lawrence; Ma, Qin; Sundi, Debasish; Chung, Dongjun; Li, Xue; Li, Zihai.

Sci Immunol ; 7(73): eabq2630, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35420889

17.

Molecular and Radiological Features of Microsatellite Stable Colorectal Cancer Cases With Dramatic Responses to Immunotherapy.

Keenan, Bridget P; VAN Loon, Katherine; Khilnani, Anuradha D; Fidelman, Nicholas; Behr, Spencer C; Atreya, Chloe E; Oh, David Y.

Anticancer Res ; 41(6): 2985-2992, 2021 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-34083289

18.

Toward a better understanding of T cells in cancer.

Oh, David Y; Fong, Lawrence; Newell, Evan W; Turk, Mary Jo; Chi, Hongbo; Chang, Howard Y; Satpathy, Ansuman T; Fairfax, Benjamin; Silva-Santos, Bruno; Lantz, Olivier.

Cancer Cell ; 39(12): 1549-1552, 2021 12 13.

Artigo em Inglês | MEDLINE | ID: mdl-34906313

19.

In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.

Zhao, Ning; Bardine, Conner; Lourenço, André Luiz; Wang, Yung-Hua; Huang, Yangjie; Cleary, Simon J; Wilson, David M; Oh, David Y; Fong, Lawrence; Looney, Mark R; Evans, Michael J; Craik, Charles S.

ACS Cent Sci ; 7(10): 1638-1649, 2021 Oct 27.

Artigo em Inglês | MEDLINE | ID: mdl-34729407

20.

TERT promoter mutations and other prognostic factors in patients with advanced urothelial carcinoma treated with an immune checkpoint inhibitor.

de Kouchkovsky, Ivan; Zhang, Li; Philip, Errol J; Wright, Francis; Kim, Daniel M; Natesan, Divya; Kwon, Daniel; Ho, Hansen; Ho, Son; Chan, Emily; Porten, Sima P; Wong, Anthony C; Desai, Arpita; Huang, Franklin W; Chou, Jonathan; Oh, David Y; Pruthi, Raj S; Fong, Lawrence; Small, Eric J; Friedlander, Terence W; Koshkin, Vadim S.

J Immunother Cancer ; 9(5)2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33980590

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Intratumoral CD4⁺ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer.

Cytotoxic CD4⁺ T cells in cancer: Expanding the immune effector toolbox.

Non-viral precision T cell receptor replacement for personalized cell therapy.

Clonal Deletion of Tumor-Specific T Cells by Interferon-Î³ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.

Immunity in the Time of Metastases.

Early changes in the circulating T cells are associated with clinical outcomes after PD-L1 blockade by durvalumab in advanced NSCLC patients.

Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors.

Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes.

On the Verge: Immunotherapy for Colorectal Carcinoma.

Balancing the Checkpoint: Managing Colitis Associated with Dual Checkpoint Inhibitors and High-Dose Aspirin.

Dysregulation of CD4⁺ and CD8⁺ resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis.

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis.

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis.

Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results.

Preparation of Radiolabeled Antibodies for Nuclear Medicine Applications in Immuno-Oncology.

Androgen conspires with the CD8⁺ T cell exhaustion program and contributes to sex bias in cancer.

Molecular and Radiological Features of Microsatellite Stable Colorectal Cancer Cases With Dramatic Responses to Immunotherapy.

Toward a better understanding of T cells in cancer.

In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.

TERT promoter mutations and other prognostic factors in patients with advanced urothelial carcinoma treated with an immune checkpoint inhibitor.