Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions.

Urano, Emiko; Okamura, Tomotaka; Ono, Chikako; Ueno, Shiori; Nagata, Satoshi; Kamada, Haruhiko; Higuchi, Mahoko; Furukawa, Mugi; Kamitani, Wataru; Matsuura, Yoshiharu; Kawaoka, Yoshihiro; Yasutomi, Yasuhiro.

Proc Natl Acad Sci U S A ; 118(43)2021 10 26.

Artigo em Inglês | MEDLINE | ID: mdl-34625475

2.

Establishment of a Cynomolgus Macaque Model of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Direct Inoculation of Adult T-Cell Leukemia Patient-Derived Cell Lines for HTLV-1 Infection.

Urano, Emiko; Ueda, Kayoko; Higuchi, Mahoko; Furukawa, Mugi; Okamura, Tomotaka; Tanaka, Yuetsu; Yasutomi, Yasuhiro.

J Virol ; 96(22): e0133922, 2022 11 23.

Artigo em Inglês | MEDLINE | ID: mdl-36314828

3.

CD8 T Cells Show Protection against Highly Pathogenic Simian Immunodeficiency Virus (SIV) after Vaccination with SIV Gene-Expressing BCG Prime and Vaccinia Virus/Sendai Virus Vector Boosts.

Kato, Seiichi; Shida, Hisatoshi; Okamura, Tomotaka; Zhang, Xianfeng; Miura, Tomoyuki; Mukai, Tetsu; Inoue, Makoto; Shu, Tsugumine; Naruse, Taeko K; Kimura, Akinori; Yasutomi, Yasuhiro; Matsuo, Kazuhiro.

J Virol ; 95(4)2021 01 28.

Artigo em Inglês | MEDLINE | ID: mdl-33087465

4.

Vaccination with Intradermal Bacillus Calmette-Guérin Provides Robust Protection against Extrapulmonary Tuberculosis but Not Pulmonary Infection in Cynomolgus Macaques.

Tsujimura, Yusuke; Shiogama, Yumiko; Soma, Shogo; Okamura, Tomotaka; Takano, Junichiro; Urano, Emiko; Murakata, Yoshiko; Kawano, Akira; Yamakawa, Natsuko; Asaka, Masamitsu N; Matsuo, Kazuhiro; Yasutomi, Yasuhiro.

J Immunol ; 205(11): 3023-3036, 2020 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-33097574

5.

Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions.

Watanabe, Satoru; Fujino, Masayuki; Saito, Yohei; Ahmed, Nursarat; Sato, Hirotaka; Sugimoto, Chie; Okamura, Tomotaka; Hanaki, Kenichi; Nakayama, Emi E; Shioda, Tatsuo; Matsushima, Kouji; Ansari, Aftab A; Villinger, Francois; Mori, Kazuyasu.

J Immunol ; 205(5): 1331-1344, 2020 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-32747501

6.

Repeated Intravaginal Inoculation of Zika Virus Protects Cynomolgus Monkeys from Subcutaneous Superchallenge.

Shofa, Maya; Okamura, Tomotaka; Urano, Emiko; Matsuura, Yoshiharu; Yasutomi, Yasuhiro; Saito, Akatsuki.

Int J Mol Sci ; 23(22)2022 Nov 13.

Artigo em Inglês | MEDLINE | ID: mdl-36430481

7.

Simian Immunodeficiency Virus Targeting of CXCR3⁺ CD4⁺ T Cells in Secondary Lymphoid Organs Is Associated with Robust CXCL10 Expression in Monocyte/Macrophage Subsets.

Fujino, Masayuki; Sato, Hirotaka; Okamura, Tomotaka; Uda, Akihiko; Takeda, Satoshi; Ahmed, Nursarat; Shichino, Shigeyuki; Shiino, Teiichiro; Saito, Yohei; Watanabe, Satoru; Sugimoto, Chie; Kuroda, Marcelo J; Ato, Manabu; Nagai, Yoshiyuki; Izumo, Shuji; Matsushima, Kouji; Miyazawa, Masaaki; Ansari, Aftab A; Villinger, Francois; Mori, Kazuyasu.

J Virol ; 91(13)2017 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-28424283

8.

Okamura, Tomotaka; Yasutomi, Yasuhiro.

Uirusu ; 72(2): 167-170, 2023.

Artigo em Japonês | MEDLINE | ID: mdl-38220205

9.

Simian immunodeficiency virus SIVmac239 infection and simian human immunodeficiency virus SHIV89.6P infection result in progression to AIDS in cynomolgus macaques of Asian origin.

Okamura, Tomotaka; Tsujimura, Yusuke; Soma, Shogo; Takahashi, Ichiro; Matsuo, Kazuhiro; Yasutomi, Yasuhiro.

J Gen Virol ; 97(12): 3413-3426, 2016 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-27902330

10.

Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci.

Yokota, Chieko; Fujimoto, Kosuke; Yamakawa, Natsuko; Kono, Masamitsu; Miyaoka, Daichi; Shimohigoshi, Masaki; Uematsu, Miho; Watanabe, Miki; Kamei, Yukari; Sugimoto, Akira; Kawasaki, Natsuko; Yabuno, Takato; Okamura, Tomotaka; Kuroda, Eisuke; Hamaguchi, Shigeto; Sato, Shintaro; Hotomi, Muneki; Akeda, Yukihiro; Ishii, Ken J; Yasutomi, Yasuhiro; Sunami, Kishiko; Uematsu, Satoshi.

Inflamm Regen ; 43(1): 55, 2023 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-37964391

11.

An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models.

Urano, Emiko; Itoh, Yumi; Suzuki, Tatsuya; Sasaki, Takanori; Kishikawa, Jun-Ichi; Akamatsu, Kanako; Higuchi, Yusuke; Sakai, Yusuke; Okamura, Tomotaka; Mitoma, Shuya; Sugihara, Fuminori; Takada, Akira; Kimura, Mari; Nakao, Shuto; Hirose, Mika; Sasaki, Tadahiro; Koketsu, Ritsuko; Tsuji, Shunya; Yanagida, Shota; Shioda, Tatsuo; Hara, Eiji; Matoba, Satoaki; Matsuura, Yoshiharu; Kanda, Yasunari; Arase, Hisashi; Okada, Masato; Takagi, Junichi; Kato, Takayuki; Hoshino, Atsushi; Yasutomi, Yasuhiro; Saito, Akatsuki; Okamoto, Toru.

Sci Transl Med ; 15(711): eadi2623, 2023 08 30.

Artigo em Inglês | MEDLINE | ID: mdl-37647387

12.

Long-term protective immunity induced by an adjuvant-containing live-attenuated AIDS virus.

Okamura, Tomotaka; Shimizu, Yuya; Asaka, Masamitsu N; Kanuma, Tomohiro; Tsujimura, Yusuke; Yamamoto, Takuya; Matsuo, Kazuhiro; Yasutomi, Yasuhiro.

NPJ Vaccines ; 6(1): 124, 2021 Oct 22.

Artigo em Inglês | MEDLINE | ID: mdl-34686680

13.

STING agonists activate latently infected cells and enhance SIV-specific responses ex vivo in naturally SIV controlled cynomolgus macaques.

Yamamoto, Takuya; Kanuma, Tomohiro; Takahama, Shokichi; Okamura, Tomotaka; Moriishi, Eiko; Ishii, Ken J; Terahara, Kazutaka; Yasutomi, Yasuhiro.

Sci Rep ; 9(1): 5917, 2019 04 11.

Artigo em Inglês | MEDLINE | ID: mdl-30976083

14.

Partial Deletion of Glycoprotein B5R Enhances Vaccinia Virus Neutralization Escape while Preserving Oncolytic Function.

Nakatake, Motomu; Kurosaki, Hajime; Kuwano, Nozomi; Horita, Kosuke; Ito, Mai; Kono, Hiromichi; Okamura, Tomotaka; Hasegawa, Kosei; Yasutomi, Yasuhiro; Nakamura, Takafumi.

Mol Ther Oncolytics ; 14: 159-171, 2019 Sep 27.

Artigo em Inglês | MEDLINE | ID: mdl-31236440

15.

Expression of Bcl-2 in feline lymphoma cell lines.

Kano, Rui; Sato, Eimi; Okamura, Tomotaka; Watanabe, Shinichi; Hasegawa, Atsuhiko.

Vet Clin Pathol ; 37(1): 57-60, 2008 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-18366545

16.

Thiazole orange positive platelets in a dog with Evans' syndrome.

Michimoto, Takeshi; Okamura, Tomotaka; Suzuki, Kumiko; Watari, Toshihiro; Kano, Rui; Hasegawa, Atsuhiko.

J Vet Med Sci ; 66(10): 1305-6, 2004 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-15528872

17.

Recombinant Ag85B vaccine by taking advantage of characteristics of human parainfluenza type 2 virus vector showed Mycobacteria-specific immune responses by intranasal immunization.

Watanabe, Kenta; Matsubara, Akihiro; Kawano, Mitsuo; Mizuno, Satoru; Okamura, Tomotaka; Tsujimura, Yusuke; Inada, Hiroyasu; Nosaka, Tetsuya; Matsuo, Kazuhiro; Yasutomi, Yasuhiro.

Vaccine ; 32(15): 1727-35, 2014 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-24486310

18.

Immunogenicity of newly constructed attenuated vaccinia strain LC16m8Delta that expresses SIV Gag protein.

Suzuki, Hajime; Kidokoro, Minoru; Fofana, Ismael Ben; Ohashi, Takashi; Okamura, Tomotaka; Matsuo, Kazuhiro; Yamamoto, Naoki; Shida, Hisatoshi.

Vaccine ; 27(7): 966-71, 2009 Feb 11.

Artigo em Inglês | MEDLINE | ID: mdl-19135118

19.

Recombinant vaccinia DIs expressing simian immunodeficiency virus gag and pol in mammalian cells induces efficient cellular immunity as a safe immunodeficiency virus vaccine candidate.

Okamura, Tomotaka; Someya, Kenji; Matsuo, Kazuhiro; Hasegawa, Atsuhiko; Yamamoto, Naoki; Honda, Mitsuo.

Microbiol Immunol ; 50(12): 989-1000, 2006.

Artigo em Inglês | MEDLINE | ID: mdl-17179668

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