Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma.

Hassel, Jessica C; Piperno-Neumann, Sophie; Rutkowski, Piotr; Baurain, Jean-Francois; Schlaak, Max; Butler, Marcus O; Sullivan, Ryan J; Dummer, Reinhard; Kirkwood, John M; Orloff, Marlana; Sacco, Joseph J; Ochsenreither, Sebastian; Joshua, Anthony M; Gastaud, Lauris; Curti, Brendan; Piulats, Josep M; Salama, April K S; Shoushtari, Alexander N; Demidov, Lev; Milhem, Mohammed; Chmielowski, Bartosz; Kim, Kevin B; Carvajal, Richard D; Hamid, Omid; Collins, Laura; Ranade, Koustubh; Holland, Chris; Pfeiffer, Constance; Nathan, Paul.

N Engl J Med ; 389(24): 2256-2266, 2023 Dec 14.

Artigo em Inglês | MEDLINE | ID: mdl-37870955

2.

Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma.

Nathan, Paul; Hassel, Jessica C; Rutkowski, Piotr; Baurain, Jean-Francois; Butler, Marcus O; Schlaak, Max; Sullivan, Ryan J; Ochsenreither, Sebastian; Dummer, Reinhard; Kirkwood, John M; Joshua, Anthony M; Sacco, Joseph J; Shoushtari, Alexander N; Orloff, Marlana; Piulats, Josep M; Milhem, Mohammed; Salama, April K S; Curti, Brendan; Demidov, Lev; Gastaud, Lauris; Mauch, Cornelia; Yushak, Melinda; Carvajal, Richard D; Hamid, Omid; Abdullah, Shaad E; Holland, Chris; Goodall, Howard; Piperno-Neumann, Sophie.

N Engl J Med ; 385(13): 1196-1206, 2021 09 23.

Artigo em Inglês | MEDLINE | ID: mdl-34551229

3.

Efficacy and Safety of the Melphalan/Hepatic Delivery System in Patients with Unresectable Metastatic Uveal Melanoma: Results from an Open-Label, Single-Arm, Multicenter Phase 3 Study.

Zager, Jonathan S; Orloff, Marlana; Ferrucci, Pier Francesco; Choi, Junsung; Eschelman, David J; Glazer, Evan S; Ejaz, Aslam; Howard, J Harrison; Richtig, Erika; Ochsenreither, Sebastian; Reddy, Sunil A; Lowe, Michael C; Beasley, Georgia M; Gesierich, Anja; Bender, Armin; Gschnell, Martin; Dummer, Reinhard; Rivoire, Michel; Arance, Ana; Fenwick, Stephen William; Sacco, Joseph J; Haferkamp, Sebastian; Weishaupt, Carsten; John, Johnny; Wheater, Matthew; Ottensmeier, Christian H.

Ann Surg Oncol ; 2024 May 04.

Artigo em Inglês | MEDLINE | ID: mdl-38704501

4.

Mutational Landscape and Outcomes of Conjunctival Melanoma in 101 Patients.

Lally, Sara E; Milman, Tatyana; Orloff, Marlana; Dalvin, Lauren A; Eberhart, Charles G; Heaphy, Christopher M; Rodriguez, Fausto J; Lin, Chun-Chieh; Dockery, Philip W; Shields, Jerry A; Shields, Carol L.

Ophthalmology ; 129(6): 679-693, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35085662

5.

Treatment of Metastatic Melanoma in the Elderly.

Seedor, Rino S; Orloff, Marlana.

Curr Oncol Rep ; 24(7): 825-833, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35316844

6.

A Prospective Phase II Trial of Radioembolization for Treatment of Uveal Melanoma Hepatic Metastasis.

Gonsalves, Carin F; Eschelman, David J; Adamo, Robert D; Anne, P Rani; Orloff, Marlana M; Terai, Mizue; Hage, Anthony N; Yi, Misung; Chervoneva, Inna; Sato, Takami.

Radiology ; 293(1): 223-231, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31453767

7.

ASO Visual Abstract: Efficacy and Safety of Melphalan/Hepatic Delivery System in Patients with Unresectable Metastatic Uveal Melanoma: Results from an Open-Label, Single-Arm, Multicenter, Phase 3 Study.

Zager, Jonathan S; Orloff, Marlana; Ferrucci, Pier Francesco; Choi, Junsung; Eschelman, David J; Glazer, Evan S; Ejaz, Aslam; Howard, J Harrison; Richtig, Erika; Ochsenreither, Sebastian; Reddy, Sunil A; Lowe, Michael C; Beasley, Georgia M; Gesierich, Anja; Bender, Armin; Gschnell, Martin; Dummer, Reinhard; Rivoire, Michel; Arance, Ana; Fenwick, Stephen William; Sacco, Joseph J; Haferkamp, Sebastian; Weishaupt, Carsten; John, Johnny; Wheater, Matthew; Ottensmeier, Christian H.

Ann Surg Oncol ; 2024 May 24.

Artigo em Inglês | MEDLINE | ID: mdl-38789613

8.

Adjuvant Sunitinib in High-Risk Patients with Uveal Melanoma: Comparison with Institutional Controls.

Valsecchi, Matias E; Orloff, Marlana; Sato, Rino; Chervoneva, Inna; Shields, Carol L; Shields, Jerry A; Mastrangelo, Michael J; Sato, Takami.

Ophthalmology ; 125(2): 210-217, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-28935400

9.

Melanoma Immunotherapy in the Elderly.

Orloff, Marlana.

Curr Oncol Rep ; 20(2): 20, 2018 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-29500787

10.

CHECKPOINT INHIBITOR IMMUNE THERAPY: Systemic Indications and Ophthalmic Side Effects.

Dalvin, Lauren A; Shields, Carol L; Orloff, Marlana; Sato, Takami; Shields, Jerry A.

Retina ; 38(6): 1063-1078, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29689030

11.

Biosafety and biohazard considerations of HSV-1-based oncolytic viral immunotherapy.

Robilotti, Elizabeth; Zeitouni, Nathalie C; Orloff, Marlana.

Front Mol Biosci ; 10: 1178382, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37795219

12.

Tebentafusp in combination with durvalumab and/or tremelimumab in patients with metastatic cutaneous melanoma: a phase 1 study.

Hamid, Omid; Hassel, Jessica C; Shoushtari, Alexander N; Meier, Friedegund; Bauer, Todd M; Salama, April K S; Kirkwood, John M; Ascierto, Paolo A; Lorigan, Paul C; Mauch, Cornelia; Orloff, Marlana; Evans, Thomas R Jeffry; Holland, Chris; Edukulla, Ramakrishna; Abedin, Shaad E; Middleton, Mark R.

J Immunother Cancer ; 11(6)2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-37286303

13.

Proceedings from the Melanoma Research Foundation Mucosal Melanoma Meeting (December 16, 2022, New York, USA).

Wei, Alexander Z; Chen, Lanyi N; Orloff, Marlana; Ariyan, Charlotte E; Asgari, Maryam; Barker, Christopher A; Buchbinder, Elizabeth; Chandra, Sunandana; Couts, Kasey; Frumovitz, Michael M; Futreal, Andrew; Gershenwald, Jeffrey E; Hanna, Ehab Y; Izar, Benjamin; LeBlanc, Amy K; Leitao, Mario M; Lipson, Evan J; Liu, David; McCarter, Martin; McQuade, Jennifer L; Najjar, Yana; Rapisuwon, Suthee; Selig, Sara; Shoushtari, Alexander N; Yeh, Iwei; Schwartz, Gary K; Guo, Jun; Patel, Sapna P; Carvajal, Richard D.

Pigment Cell Melanoma Res ; 36(6): 542-556, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37804122

14.

Review of bi-specific therapies in uveal melanoma.

Orloff, Marlana; Seedor, Rino; Sato, Takami.

Cancer Gene Ther ; 29(12): 1814-1818, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-35236927

15.

Conditional survival of uveal melanoma using The Cancer Genome Atlas (TCGA) classification (Simplified Version) in 1001 cases.

Shields, Carol L; Dockery, Philip W; Mayro, Eileen L; Bas, Zeynep; Yaghy, Antonio; Lally, Sara E; Orloff, Marlana; Sato, Takami; Shields, Jerry A.

Saudi J Ophthalmol ; 36(3): 308-314, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-36276251

16.

Phase I Study of Safety, Tolerability, and Efficacy of Tebentafusp Using a Step-Up Dosing Regimen and Expansion in Patients With Metastatic Uveal Melanoma.

Carvajal, Richard D; Nathan, Paul; Sacco, Joseph J; Orloff, Marlana; Hernandez-Aya, Leonel F; Yang, Jessica; Luke, Jason J; Butler, Marcus O; Stanhope, Sarah; Collins, Laura; McAlpine, Cheryl; Holland, Chris; Abdullah, Shaad E; Sato, Takami.

J Clin Oncol ; 40(17): 1939-1948, 2022 06 10.

Artigo em Inglês | MEDLINE | ID: mdl-35254876

17.

A Pilot Study of Hepatic Irradiation with Yttrium-90 Microspheres Followed by Immunotherapy with Ipilimumab and Nivolumab for Metastatic Uveal Melanoma.

Minor, David R; Kim, Kevin B; Tong, Ricky T; Wu, Max C; Kashani-Sabet, Mohammed; Orloff, Marlana; Eschelman, David J; Gonsalves, Carlin F; Adamo, Robert D; Anne, Pramila R; Luke, Jason J; Char, Devron; Sato, Takami.

Cancer Biother Radiopharm ; 37(1): 11-16, 2022 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-35021863

18.

Characterizing metastatic uveal melanoma patients who develop symptomatic brain metastases.

Wei, Alexander Z; Uriel, Matan; Porcu, Agata; Manos, Michael P; Mercurio, Ann C; Caplan, Michael M; Hulse, Liam; Seedor, Rino S; Holovatska, Marta; Francis, Jasmine; Khan, Shaheer A; McDonnell, Diana E; Bogomolny, Dmitry; Sato, Takami; Marr, Brian P; Haq, Rizwan; Orloff, Marlana; Shoushtari, Alexander; Carvajal, Richard D.

Front Oncol ; 12: 961517, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-36212499

19.

Efficacy and safety of lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in patients with advanced melanoma after progression on immune checkpoint inhibitors and targeted therapies: pooled analysis of consecutive cohorts of the C-144-01 study.

Chesney, Jason; Lewis, Karl D; Kluger, Harriet; Hamid, Omid; Whitman, Eric; Thomas, Sajeve; Wermke, Martin; Cusnir, Mike; Domingo-Musibay, Evidio; Phan, Giao Q; Kirkwood, John M; Hassel, Jessica C; Orloff, Marlana; Larkin, James; Weber, Jeffrey; Furness, Andrew J S; Khushalani, Nikhil I; Medina, Theresa; Egger, Michael E; Graf Finckenstein, Friedrich; Jagasia, Madan; Hari, Parameswaran; Sulur, Giri; Shi, Wen; Wu, Xiao; Sarnaik, Amod.

J Immunother Cancer ; 10(12)2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36600653

20.

Clinical Trials in Metastatic Uveal Melanoma: Immunotherapy.