Detalhe da pesquisa
1.
Sequence grammar underlying the unfolding and phase separation of globular proteins.
Mol Cell
; 82(17): 3193-3208.e8, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35853451
2.
Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate.
J Biol Chem
; 299(1): 102774, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36481270
3.
A biosensor of protein foldedness identifies increased "holdase" activity of chaperones in the nucleus following increased cytosolic protein aggregation.
J Biol Chem
; 298(8): 102158, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35724963
4.
Widespread remodeling of proteome solubility in response to different protein homeostasis stresses.
Proc Natl Acad Sci U S A
; 117(5): 2422-2431, 2020 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31964829
5.
Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity.
Mol Cell Proteomics
; 19(4): 640-654, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32086375
6.
Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.
Mol Cell Neurosci
; 83: 103-112, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28743452
7.
Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells.
Phys Chem Chem Phys
; 19(17): 10738-10747, 2017 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28094373
8.
Tracking protein aggregation and mislocalization in cells with flow cytometry.
Nat Methods
; 9(5): 467-70, 2012 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22426490
9.
A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70.
J Biol Chem
; 288(52): 37192-203, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24196953
10.
Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli.
NPJ Syst Biol Appl
; 8(1): 46, 2022 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36443335
11.
Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA.
PLoS One
; 15(7): e0233583, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32735619
12.
A biosensor-based framework to measure latent proteostasis capacity.
Nat Commun
; 9(1): 287, 2018 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29348634
13.
Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length.
J Mol Biol
; 430(10): 1442-1458, 2018 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29627459
14.
N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.
J Huntingtons Dis
; 6(1): 79-91, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28339398
15.
Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.
Cell Rep
; 19(5): 919-927, 2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28467905
16.
Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation.
Nat Struct Mol Biol
; 22(12): 1008-15, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26571108
17.
Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src.
PLoS One
; 8(7): e71035, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23923048
18.
Widespread remodeling of proteome solubility in response to different protein homeostasis stresses
Artigo
em Inglês
| Arca: Repositório institucional da Fiocruz | ID: arc-58478