Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Phase Ib study of sabatolimab (MBG453), a novel immunotherapy targeting TIM-3 antibody, in combination with decitabine or azacitidine in high- or very high-risk myelodysplastic syndromes.

Brunner, Andrew M; Esteve, Jordi; Porkka, Kimmo; Knapper, Steve; Traer, Elie; Scholl, Sebastian; Garcia-Manero, Guillermo; Vey, Norbert; Wermke, Martin; Janssen, Jeroen J W M; Narayan, Rupa; Fleming, Shaun; Loo, Sun; Tovar, Natalia; Kontro, Mika; Ottmann, Oliver G; Naidu, Purushotham; Sun, Haiying; Han, May; White, Roisin; Zhang, Na; Mohammed, Anisa; Sabatos-Peyton, Catherine A; Steensma, David P; Rinne, Mikael L; Borate, Uma M; Wei, Andrew H.

Am J Hematol ; 99(2): E32-E36, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-37994196

2.

Dynamics of mutations in patients with essential thrombocythemia treated with imetelstat.

Oppliger Leibundgut, Elisabeth; Haubitz, Monika; Burington, Bart; Ottmann, Oliver G; Spitzer, Gary; Odenike, Olatoyosi; McDevitt, Michael A; Röth, Alexander; Snyder, David S; Baerlocher, Gabriela M.

Haematologica ; 106(9): 2397-2404, 2021 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-32732354

3.

Blinatumomab compared with standard of care for the treatment of adult patients with relapsed/refractory Philadelphia chromosome-positive B-precursor acute lymphoblastic leukemia.

Rambaldi, Alessandro; Ribera, Josep-Maria; Kantarjian, Hagop M; Dombret, Hervé; Ottmann, Oliver G; Stein, Anthony S; Tuglus, Catherine A; Zhao, Xiaoyue; Kim, Christopher; Martinelli, Giovanni.

Cancer ; 126(2): 304-310, 2020 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-31626339

4.

CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells.

Legut, Mateusz; Dolton, Garry; Mian, Afsar Ali; Ottmann, Oliver G; Sewell, Andrew K.

Blood ; 131(3): 311-322, 2018 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-29122757

5.

Genomic CDKN2A/2B deletions in adult Ph⁺ ALL are adverse despite allogeneic stem cell transplantation.

Pfeifer, Heike; Raum, Katharina; Markovic, Sandra; Nowak, Verena; Fey, Stephanie; Obländer, Julia; Pressler, Jovita; Böhm, Verena; Brüggemann, Monika; Wunderle, Lydia; Hüttmann, Andreas; Wäsch, Ralph; Beck, Joachim; Stelljes, Matthias; Viardot, Andreas; Lang, Fabian; Hoelzer, Dieter; Hofmann, Wolf-Karsten; Serve, Hubert; Weiss, Christel; Goekbuget, Nicola; Ottmann, Oliver G; Nowak, Daniel.

Blood ; 131(13): 1464-1475, 2018 03 29.

Artigo em Inglês | MEDLINE | ID: mdl-29348129

6.

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia.

Baerlocher, Gabriela M; Oppliger Leibundgut, Elisabeth; Ottmann, Oliver G; Spitzer, Gary; Odenike, Olatoyosi; McDevitt, Michael A; Röth, Alexander; Daskalakis, Michael; Burington, Bart; Stuart, Monic; Snyder, David S.

N Engl J Med ; 373(10): 920-8, 2015 Sep 03.

Artigo em Inglês | MEDLINE | ID: mdl-26332546

7.

Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome-positive ALL.

Rousselot, Philippe; Coudé, Marie Magdelaine; Gokbuget, Nicola; Gambacorti Passerini, Carlo; Hayette, Sandrine; Cayuela, Jean-Michel; Huguet, Françoise; Leguay, Thibaut; Chevallier, Patrice; Salanoubat, Celia; Bonmati, Caroline; Alexis, Magda; Hunault, Mathilde; Glaisner, Sylvie; Agape, Philippe; Berthou, Christian; Jourdan, Eric; Fernandes, José; Sutton, Laurent; Banos, Anne; Reman, Oumedaly; Lioure, Bruno; Thomas, Xavier; Ifrah, Norbert; Lafage-Pochitaloff, Marina; Bornand, Anne; Morisset, Laure; Robin, Valérie; Pfeifer, Heike; Delannoy, Andre; Ribera, Josep; Bassan, Renato; Delord, Marc; Hoelzer, Dieter; Dombret, Herve; Ottmann, Oliver G.

Blood ; 128(6): 774-82, 2016 08 11.

Artigo em Inglês | MEDLINE | ID: mdl-27121472

8.

TKI vs relapse after HSCT: is the jury still out?

Ottmann, Oliver G.

Blood ; 136(15): 1705-1706, 2020 10 08.

Artigo em Inglês | MEDLINE | ID: mdl-33031524

9.

Continuously expanding CAR NK-92 cells display selective cytotoxicity against B-cell leukemia and lymphoma.

Oelsner, Sarah; Friede, Miriam E; Zhang, Congcong; Wagner, Juliane; Badura, Susanne; Bader, Peter; Ullrich, Evelyn; Ottmann, Oliver G; Klingemann, Hans; Tonn, Torsten; Wels, Winfried S.

Cytotherapy ; 19(2): 235-249, 2017 02.

Artigo em Inglês | MEDLINE | ID: mdl-27887866

10.

CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell malignancies.

Romanski, Annette; Uherek, Christoph; Bug, Gesine; Seifried, Erhard; Klingemann, Hans; Wels, Winfried S; Ottmann, Oliver G; Tonn, Torsten.

J Cell Mol Med ; 20(7): 1287-94, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27008316

11.

Chimeric antigen receptor-engineered cytokine-induced killer cells overcome treatment resistance of pre-B-cell acute lymphoblastic leukemia and enhance survival.

Oelsner, Sarah; Wagner, Juliane; Friede, Miriam E; Pfirrmann, Verena; Genßler, Sabrina; Rettinger, Eva; Buchholz, Christian J; Pfeifer, Heike; Schubert, Ralf; Ottmann, Oliver G; Ullrich, Evelyn; Bader, Peter; Wels, Winfried S.

Int J Cancer ; 139(8): 1799-809, 2016 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-27253354

12.

Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy.

Döhner, Hartmut; Lübbert, Michael; Fiedler, Walter; Fouillard, Loic; Haaland, Alf; Brandwein, Joseph M; Lepretre, Stephane; Reman, Oumedaly; Turlure, Pascal; Ottmann, Oliver G; Müller-Tidow, Carsten; Krämer, Alwin; Raffoux, Emmanuel; Döhner, Konstanze; Schlenk, Richard F; Voss, Florian; Taube, Tillmann; Fritsch, Holger; Maertens, Johan.

Blood ; 124(9): 1426-33, 2014 Aug 28.

Artigo em Inglês | MEDLINE | ID: mdl-25006120

13.

Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma.

Seggewiss-Bernhardt, Ruth; Bargou, Ralf C; Goh, Yeow Tee; Stewart, A Keith; Spencer, Andrew; Alegre, Adrian; Bladé, Joan; Ottmann, Oliver G; Fernandez-Ibarra, Cristina; Lu, Hong; Pain, Scott; Akimov, Mikhail; Iyer, Swaminathan Padmanabhan.

Cancer ; 121(13): 2185-92, 2015 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-25809731

14.

Phase I dose-escalation trial investigating volasertib as monotherapy or in combination with cytarabine in patients with relapsed/refractory acute myeloid leukaemia.

Ottmann, Oliver G; Müller-Tidow, Carsten; Krämer, Alwin; Schlenk, Richard F; Lübbert, Michael; Bug, Gesine; Krug, Utz; Bochtler, Tilmann; Voss, Florian; Taube, Tillmann; Liu, Dan; Garin-Chesa, Pilar; Döhner, Hartmut.

Br J Haematol ; 184(6): 1018-1021, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-29882583

15.

A phase I trial investigating the Aurora B kinase inhibitor BI 811283 in combination with cytarabine in patients with acute myeloid leukaemia.

Döhner, Hartmut; Müller-Tidow, Carsten; Lübbert, Michael; Fiedler, Walter; Krämer, Alwin; Westermann, Jörg; Bug, Gesine; Schlenk, Richard F; Krug, Utz; Goeldner, Rainer-Georg; Hilbert, James; Taube, Tillmann; Ottmann, Oliver G.

Br J Haematol ; 185(3): 583-587, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30450591

16.

Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL.

Topp, Max S; Gökbuget, Nicola; Zugmaier, Gerhard; Degenhard, Evelyn; Goebeler, Marie-Elisabeth; Klinger, Matthias; Neumann, Svenja A; Horst, Heinz A; Raff, Thorsten; Viardot, Andreas; Stelljes, Matthias; Schaich, Markus; Köhne-Volland, Rudolf; Brüggemann, Monika; Ottmann, Oliver G; Burmeister, Thomas; Baeuerle, Patrick A; Nagorsen, Dirk; Schmidt, Margit; Einsele, Hermann; Riethmüller, Gert; Kneba, Michael; Hoelzer, Dieter; Kufer, Peter; Bargou, Ralf C.

Blood ; 120(26): 5185-7, 2012 Dec 20.

Artigo em Inglês | MEDLINE | ID: mdl-23024237

17.

Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies.

Jabbour, Elias; Ottmann, Oliver G; Deininger, Michael; Hochhaus, Andreas.

Haematologica ; 99(1): 7-18, 2014 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24425689

18.

Long-term results of a prospective randomized trial evaluating G-CSF priming in intensive induction chemotherapy followed by autologous stem cell transplantation in elderly patients with acute myeloid leukemia.

Bug, Gesine; Koschmieder, Steffen; Krauter, Juergen; Heuser, Michael; Thol, Felicitas; Wiebe, Stefanie; Hofmann, Wolf-Karsten; Klein, Stefan A; Wegener, Gerd; Göhring, Gudrun; Heit, Wolfgang; Hoelzer, Dieter; Ganser, Arnold; Ottmann, Oliver G.

Ann Hematol ; 93(2): 193-202, 2014 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-23978944

19.

A randomized, open-label, phase I/II trial to investigate the maximum tolerated dose of the Polo-like kinase inhibitor BI 2536 in elderly patients with refractory/relapsed acute myeloid leukaemia.

Müller-Tidow, Carsten; Bug, Gesine; Lübbert, Michael; Krämer, Alwin; Krauter, Jürgen; Valent, Peter; Nachbaur, David; Berdel, Wolfgang E; Ottmann, Oliver G; Fritsch, Holger; Munzert, Gerd; Garin-Chesa, Pilar; Fleischer, Frank; Taube, Tillmann; Döhner, Hartmut.

Br J Haematol ; 163(2): 214-22, 2013 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-24033250

20.

Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up results.

Kantarjian, Hagop M; Giles, Francis J; Bhalla, Kapil N; Pinilla-Ibarz, Javier; Larson, Richard A; Gattermann, Norbert; Ottmann, Oliver G; Hochhaus, Andreas; Radich, Jerald P; Saglio, Giuseppe; Hughes, Timothy P; Martinelli, Giovanni; Kim, Dong-Wook; Shou, Yaping; Gallagher, Neil J; Blakesley, Rick; Baccarani, Michele; Cortes, Jorge; le Coutre, Philipp D.

Blood ; 117(4): 1141-5, 2011 Jan 27.

Artigo em Inglês | MEDLINE | ID: mdl-21098399

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