Detalhe da pesquisa
1.
Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain.
Bioorg Med Chem Lett
; 20(2): 465-8, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20005703
2.
2-Amino-5-aryl-pyridines as selective CB2 agonists: synthesis and investigation of structure-activity relationships.
Bioorg Med Chem Lett
; 19(23): 6578-81, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19864133
3.
Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.
Bioorg Med Chem Lett
; 19(15): 4504-8, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19520573
4.
An unusual methylene aziridine refined in P2(1)/c and the nonstandard setting P2(1)/n.
Acta Crystallogr C
; 65(Pt 12): o635-8, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19966448
5.
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).
J Med Chem
; 61(16): 7314-7329, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30091600
6.
Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J Med Chem
; 59(23): 10738-10749, 2016 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27933945
7.
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J Med Chem
; 59(11): 5356-67, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27167608
8.
Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.
ACS Med Chem Lett
; 6(7): 798-803, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26191369
9.
The intramolecular amination of allenes.
Chem Commun (Camb)
; 46(16): 2835-7, 2010 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20369199