Detalhe da pesquisa
1.
Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector.
J Med Chem
; 67(7): 5216-5232, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38527911
2.
Metal-free reactions of alkynes via electrophilic iodocarbocyclizations.
Org Biomol Chem
; 10(40): 8041-7, 2012 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22987122
3.
Domino reactions consisting of heterocyclization and 1,2-migration-redox-neutral and oxidative transition-metal catalysis.
Angew Chem Int Ed Engl
; 50(42): 9965-8, 2011 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21898734
4.
Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 64(9): 6037-6058, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33939425
5.
Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases.
J Med Chem
; 64(19): 14557-14586, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34581584