Detalhe da pesquisa
1.
Overexpression of the Cdk5 inhibitory peptide in motor neurons rescue of amyotrophic lateral sclerosis phenotype in a mouse model.
Hum Mol Genet
; 28(19): 3175-3187, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31189016
2.
Rapid, quantitative therapeutic screening for Alzheimer's enzymes enabled by optimal signal transduction with transistors.
Analyst
; 145(8): 2925-2936, 2020 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32159165
3.
Peripheral and orofacial pain sensation is unaffected by the loss of p39.
Mol Pain
; 13: 1744806917737205, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28969475
4.
Squid Giant Axon Contains Neurofilament Protein mRNA but does not Synthesize Neurofilament Proteins.
Cell Mol Neurobiol
; 37(3): 475-486, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-27207029
5.
Divergent and convergent roles for kinases and phosphatases in neurofilament dynamics.
J Cell Sci
; 127(Pt 18): 4064-77, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25015294
6.
Detection and characterization of nonspecific, sparsely populated binding modes in the early stages of complexation.
J Comput Chem
; 36(13): 983-95, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25782918
7.
Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.
J Neurosci
; 33(1): 334-43, 2013 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23283346
8.
A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice.
FASEB J
; 27(1): 174-86, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23038754
9.
Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia.
Mol Pain
; 9: 66, 2013 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24359609
10.
Topographic regulation of neuronal intermediate filaments by phosphorylation, role of peptidyl-prolyl isomerase 1: significance in neurodegeneration.
Histochem Cell Biol
; 140(1): 23-32, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23793952
11.
Impaired neurogenesis and neurite outgrowth in an HIV-gp120 transgenic model is reversed by exercise via BDNF production and Cdk5 regulation.
J Neurovirol
; 19(5): 418-31, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23982957
12.
Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs.
FASEB J
; 25(11): 3896-905, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21828286
13.
Computational Study of the Allosteric Effects of p5 on CDK5-p25 Hyperactivity as Alternative Inhibitory Mechanisms in Neurodegeneration.
J Phys Chem B
; 126(27): 5033-5044, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35771127
14.
Cyclin-Dependent Kinase 5 Regulates cPLA2 Activity and Neuroinflammation in Parkinson's Disease.
eNeuro
; 9(6)2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36351818
15.
Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity.
J Neurosci
; 30(25): 8457-67, 2010 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20573893
16.
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
J Biol Chem
; 285(44): 34202-12, 2010 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-20720012
17.
Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQ.
FASEB J
; 24(11): 4396-407, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20624930
18.
Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins.
J Neurosci
; 29(47): 14869-80, 2009 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19940183
19.
Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival.
Mol Biol Cell
; 18(2): 404-13, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17108320
20.
Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons.
Mol Biol Cell
; 18(9): 3645-55, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17626162