Detalhe da pesquisa
1.
Discovery of agonist-antagonist pairs for the modulation of Ca [2]+ and voltage-gated K+ channels of large conductance that contain beta1 subunits.
Bioorg Med Chem
; 68: 116876, 2022 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35716586
2.
Optical control of sphingosine-1-phosphate formation and function.
Nat Chem Biol
; 15(6): 623-631, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31036923
3.
Optical Control of Lysophosphatidic Acid Signaling.
J Am Chem Soc
; 142(24): 10612-10616, 2020 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32469525
4.
Benchmarking GPCR homology model template selection in combination with de novo loop generation.
J Comput Aided Mol Des
; 34(10): 1027-1044, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32737667
5.
Molecular modelling guided design, synthesis and QSAR analysis of new small molecule non-lipid autotaxin inhibitors.
Bioorg Chem
; 103: 104188, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32890995
6.
A benchmark study of loop modeling methods applied to G protein-coupled receptors.
J Comput Aided Mol Des
; 33(6): 573-595, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31123958
7.
Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid.
Mol Cell
; 39(3): 421-32, 2010 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20705243
8.
Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition.
Bioorg Med Chem
; 24(19): 4660-4674, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27544588
9.
Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4.
J Biol Chem
; 289(51): 35314-25, 2014 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25371198
10.
Integrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactions.
Biochim Biophys Acta
; 1831(1): 2-12, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22982815
11.
The steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory ß1 subunit.
Proc Natl Acad Sci U S A
; 108(50): 20207-12, 2011 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22123969
12.
Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel ß1-subunit by a novel nonsteroidal agent.
Mol Pharmacol
; 83(5): 1030-44, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23455312
13.
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Mol Pharmacol
; 84(3): 415-24, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23793291
14.
Multiple cholesterol recognition/interaction amino acid consensus (CRAC) motifs in cytosolic C tail of Slo1 subunit determine cholesterol sensitivity of Ca2+- and voltage-gated K+ (BK) channels.
J Biol Chem
; 287(24): 20509-21, 2012 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22474334
15.
Gold nanorods carrying paclitaxel for photothermal-chemotherapy of cancer.
Bioconjug Chem
; 24(3): 376-86, 2013 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23360450
16.
Autotaxin inhibition: development and application of computational tools to identify site-selective lead compounds.
Bioorg Med Chem
; 21(17): 5548-60, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23816044
17.
Structural Characterization of an LPA1 Second Extracellular Loop Mimetic with a Self-Assembling Coiled-Coil Folding Constraint.
Int J Mol Sci
; 14(2): 2788-807, 2013 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23434648
18.
Application of computational methods for class A GPCR Ligand discovery.
J Mol Graph Model
; 121: 108434, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36841204
19.
Structure-based pharmacophore modeling 1. Automated random pharmacophore model generation.
J Mol Graph Model
; 121: 108429, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36804368
20.
Structure-based pharmacophore modeling 2. Developing a novel framework for structure-based pharmacophore model generation and selection.
J Mol Graph Model
; 122: 108488, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37121167