Detalhe da pesquisa
1.
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.
Proc Natl Acad Sci U S A
; 120(16): e2217864120, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37043533
2.
Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK.
J Neurochem
; 158(5): 1058-1073, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34077555
3.
Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.
Bioorg Med Chem Lett
; 26(4): 1265-1271, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26804233
4.
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Angew Chem Int Ed Engl
; 55(33): 9601-5, 2016 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27355874
5.
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
Sci Rep
; 14(1): 9064, 2024 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38643236
6.
Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.
Bioorg Med Chem Lett
; 22(5): 2015-9, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22335895
7.
Structure and functional characterization of the atypical human kinase haspin.
Proc Natl Acad Sci U S A
; 106(48): 20198-203, 2009 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19918057
8.
Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins.
J Med Chem
; 64(19): 14745-14756, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34549949
9.
Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration.
ACS Chem Neurosci
; 12(2): 271-284, 2021 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33417763
10.
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.
Sci Rep
; 11(1): 17029, 2021 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34426604
11.
Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors.
Bioorg Med Chem Lett
; 20(12): 3491-4, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20836251
12.
Structure-based screening of chemical libraries to identify small molecules that are likely to bind with the SET and RING-associated (SRA) domain of Ubiquitin-like, PHD and Ring Finger-containing 1 (UHRF1).
BMC Res Notes
; 13(1): 254, 2020 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32448288
13.
Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins.
Nucl Med Biol
; 84-85: 96-101, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32320910
14.
Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3ß) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein.
ACS Chem Neurosci
; 11(24): 4128-4138, 2020 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33253521
15.
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.
Nat Commun
; 11(1): 2484, 2020 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32424276
16.
Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion.
Transl Psychiatry
; 10(1): 76, 2020 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32094324
17.
Automethylation of G9a and its implication in wider substrate specificity and HP1 binding.
Nucleic Acids Res
; 35(21): 7313-23, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17962312
18.
Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.
Chem Commun (Camb)
; 55(86): 12932-12935, 2019 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31599282
19.
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.
Elife
; 82019 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30907729
20.
Structural Basis for Achieving GSK-3ß Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.
J Med Chem
; 62(21): 9600-9617, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31535859