Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung.

Gagne, Matthew; Corbett, Kizzmekia S; Flynn, Barbara J; Foulds, Kathryn E; Wagner, Danielle A; Andrew, Shayne F; Todd, John-Paul M; Honeycutt, Christopher Cole; McCormick, Lauren; Nurmukhambetova, Saule T; Davis-Gardner, Meredith E; Pessaint, Laurent; Bock, Kevin W; Nagata, Bianca M; Minai, Mahnaz; Werner, Anne P; Moliva, Juan I; Tucker, Courtney; Lorang, Cynthia G; Zhao, Bingchun; McCarthy, Elizabeth; Cook, Anthony; Dodson, Alan; Teng, I-Ting; Mudvari, Prakriti; Roberts-Torres, Jesmine; Laboune, Farida; Wang, Lingshu; Goode, Adrienne; Kar, Swagata; Boyoglu-Barnum, Seyhan; Yang, Eun Sung; Shi, Wei; Ploquin, Aurélie; Doria-Rose, Nicole; Carfi, Andrea; Mascola, John R; Boritz, Eli A; Edwards, Darin K; Andersen, Hanne; Lewis, Mark G; Suthar, Mehul S; Graham, Barney S; Roederer, Mario; Moore, Ian N; Nason, Martha C; Sullivan, Nancy J; Douek, Daniel C; Seder, Robert A.

Cell ; 185(1): 113-130.e15, 2022 01 06.

Artigo em Inglês | MEDLINE | ID: mdl-34921774

2.

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron.

Gagne, Matthew; Moliva, Juan I; Foulds, Kathryn E; Andrew, Shayne F; Flynn, Barbara J; Werner, Anne P; Wagner, Danielle A; Teng, I-Ting; Lin, Bob C; Moore, Christopher; Jean-Baptiste, Nazaire; Carroll, Robin; Foster, Stephanie L; Patel, Mit; Ellis, Madison; Edara, Venkata-Viswanadh; Maldonado, Nahara Vargas; Minai, Mahnaz; McCormick, Lauren; Honeycutt, Christopher Cole; Nagata, Bianca M; Bock, Kevin W; Dulan, Caitlyn N M; Cordon, Jamilet; Flebbe, Dillon R; Todd, John-Paul M; McCarthy, Elizabeth; Pessaint, Laurent; Van Ry, Alex; Narvaez, Brandon; Valentin, Daniel; Cook, Anthony; Dodson, Alan; Steingrebe, Katelyn; Nurmukhambetova, Saule T; Godbole, Sucheta; Henry, Amy R; Laboune, Farida; Roberts-Torres, Jesmine; Lorang, Cynthia G; Amin, Shivani; Trost, Jessica; Naisan, Mursal; Basappa, Manjula; Willis, Jacquelyn; Wang, Lingshu; Shi, Wei; Doria-Rose, Nicole A; Zhang, Yi; Yang, Eun Sung.

Cell ; 185(9): 1556-1571.e18, 2022 04 28.

Artigo em Inglês | MEDLINE | ID: mdl-35447072

3.

Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination at oriP and viral episome maintenance.

Dheekollu, Jayaraju; Wiedmer, Andreas; Ayyanathan, Kasirajan; Deakyne, Julianna S; Messick, Troy E; Lieberman, Paul M.

Cell ; 184(3): 643-654.e13, 2021 02 04.

Artigo em Inglês | MEDLINE | ID: mdl-33482082

4.

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.

Gangoso, Ester; Southgate, Benjamin; Bradley, Leanne; Rus, Stefanie; Galvez-Cancino, Felipe; McGivern, Niamh; Güç, Esra; Kapourani, Chantriolnt-Andreas; Byron, Adam; Ferguson, Kirsty M; Alfazema, Neza; Morrison, Gillian; Grant, Vivien; Blin, Carla; Sou, IengFong; Marques-Torrejon, Maria Angeles; Conde, Lucia; Parrinello, Simona; Herrero, Javier; Beck, Stephan; Brandner, Sebastian; Brennan, Paul M; Bertone, Paul; Pollard, Jeffrey W; Quezada, Sergio A; Sproul, Duncan; Frame, Margaret C; Serrels, Alan; Pollard, Steven M.

Cell ; 184(9): 2454-2470.e26, 2021 04 29.

Artigo em Inglês | MEDLINE | ID: mdl-33857425

5.

Autism-related dietary preferences mediate autism-gut microbiome associations.

Yap, Chloe X; Henders, Anjali K; Alvares, Gail A; Wood, David L A; Krause, Lutz; Tyson, Gene W; Restuadi, Restuadi; Wallace, Leanne; McLaren, Tiana; Hansell, Narelle K; Cleary, Dominique; Grove, Rachel; Hafekost, Claire; Harun, Alexis; Holdsworth, Helen; Jellett, Rachel; Khan, Feroza; Lawson, Lauren P; Leslie, Jodie; Frenk, Mira Levis; Masi, Anne; Mathew, Nisha E; Muniandy, Melanie; Nothard, Michaela; Miller, Jessica L; Nunn, Lorelle; Holtmann, Gerald; Strike, Lachlan T; de Zubicaray, Greig I; Thompson, Paul M; McMahon, Katie L; Wright, Margaret J; Visscher, Peter M; Dawson, Paul A; Dissanayake, Cheryl; Eapen, Valsamma; Heussler, Helen S; McRae, Allan F; Whitehouse, Andrew J O; Wray, Naomi R; Gratten, Jacob.

Cell ; 184(24): 5916-5931.e17, 2021 11 24.

Artigo em Inglês | MEDLINE | ID: mdl-34767757

6.

Zona Pellucida Proteins, Fibrils, and Matrix.

Litscher, Eveline S; Wassarman, Paul M.

Annu Rev Biochem ; 89: 695-715, 2020 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-32569527

7.

Charting the Complexity of the Marine Microbiome through Single-Cell Genomics.

Pachiadaki, Maria G; Brown, Julia M; Brown, Joseph; Bezuidt, Oliver; Berube, Paul M; Biller, Steven J; Poulton, Nicole J; Burkart, Michael D; La Clair, James J; Chisholm, Sallie W; Stepanauskas, Ramunas.

Cell ; 179(7): 1623-1635.e11, 2019 12 12.

Artigo em Inglês | MEDLINE | ID: mdl-31835036

8.

Autism-related dietary preferences mediate autism-gut microbiome associations.

Yap, Chloe X; Henders, Anjali K; Alvares, Gail A; Wood, David L A; Krause, Lutz; Tyson, Gene W; Restuadi, Restuadi; Wallace, Leanne; McLaren, Tiana; Hansell, Narelle K; Cleary, Dominique; Grove, Rachel; Hafekost, Claire; Harun, Alexis; Holdsworth, Helen; Jellett, Rachel; Khan, Feroza; Lawson, Lauren P; Leslie, Jodie; Frenk, Mira Levis; Masi, Anne; Mathew, Nisha E; Muniandy, Melanie; Nothard, Michaela; Miller, Jessica L; Nunn, Lorelle; Holtmann, Gerald; Strike, Lachlan T; de Zubicaray, Greig I; Thompson, Paul M; McMahon, Katie L; Wright, Margaret J; Visscher, Peter M; Dawson, Paul A; Dissanayake, Cheryl; Eapen, Valsamma; Heussler, Helen S; McRae, Allan F; Whitehouse, Andrew J O; Wray, Naomi R; Gratten, Jacob.

Cell ; 187(2): 495-510, 2024 Jan 18.

Artigo em Inglês | MEDLINE | ID: mdl-38242089

9.

Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation.

Tyler, Paul M; Bucklin, Molly L; Zhao, Mengting; Maher, Timothy J; Rice, Andrew J; Ji, Weizhen; Warner, Neil; Pan, Jie; Morotti, Raffaella; McCarthy, Paul; Griffiths, Anne; van Rossum, Annemarie M C; Hollink, Iris H I M; Dalm, Virgil A S H; Catanzaro, Jason; Lakhani, Saquib A; Muise, Aleixo M; Lucas, Carrie L.

Nat Immunol ; 22(9): 1118-1126, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34326534

10.

mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates.

Corbett, Kizzmekia S; Werner, Anne P; Connell, Sarah O'; Gagne, Matthew; Lai, Lilin; Moliva, Juan I; Flynn, Barbara; Choi, Angela; Koch, Matthew; Foulds, Kathryn E; Andrew, Shayne F; Flebbe, Dillon R; Lamb, Evan; Nurmukhambetova, Saule T; Provost, Samantha J; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Ry, Alex Van; Flinchbaugh, Zackery; Johnston, Timothy S; Mokhtari, Elham Bayat; Mudvari, Prakriti; Henry, Amy R; Laboune, Farida; Chang, Becky; Porto, Maciel; Wear, Jaclyn; Alvarado, Gabriela S; Boyoglu-Barnum, Seyhan; Todd, John-Paul M; Bart, Bridget; Cook, Anthony; Dodson, Alan; Pessaint, Laurent; Steingrebe, Katelyn; Elbashir, Sayda; Sriparna, Manjari; Pekosz, Andrew; Andersen, Hanne; Wu, Kai; Edwards, Darin K; Kar, Swagata; Lewis, Mark G; Boritz, Eli; Moore, Ian N; Carfi, Andrea; Suthar, Mehul S; McDermott, Adrian; Roederer, Mario.

Nat Immunol ; 22(10): 1306-1315, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34417590

11.

CD4⁺ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy.

Franken, Amelie; Bila, Michel; Mechels, Aurelie; Kint, Sam; Van Dessel, Jeroen; Pomella, Valentina; Vanuytven, Sebastiaan; Philips, Gino; Bricard, Orian; Xiong, Jieyi; Boeckx, Bram; Hatse, Sigrid; Van Brussel, Thomas; Schepers, Rogier; Van Aerde, Cedric; Geurs, Sarah; Vandecaveye, Vincent; Hauben, Esther; Vander Poorten, Vincent; Verbandt, Sara; Vandereyken, Katy; Qian, Junbin; Tejpar, Sabine; Voet, Thierry; Clement, Paul M; Lambrechts, Diether.

Immunity ; 57(3): 541-558.e7, 2024 Mar 12.

Artigo em Inglês | MEDLINE | ID: mdl-38442708

12.

Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions.

Bartleson, Juliet M; Viehmann Milam, Ashley A; Donermeyer, David L; Horvath, Stephen; Xia, Yu; Egawa, Takeshi; Allen, Paul M.

Nat Immunol ; 21(11): 1384-1396, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32989327

13.

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.

Roe, Jae-Seok; Hwang, Chang-Il; Somerville, Tim D D; Milazzo, Joseph P; Lee, Eun Jung; Da Silva, Brandon; Maiorino, Laura; Tiriac, Hervé; Young, C Megan; Miyabayashi, Koji; Filippini, Dea; Creighton, Brianna; Burkhart, Richard A; Buscaglia, Jonathan M; Kim, Edward J; Grem, Jean L; Lazenby, Audrey J; Grunkemeyer, James A; Hollingsworth, Michael A; Grandgenett, Paul M; Egeblad, Mikala; Park, Youngkyu; Tuveson, David A; Vakoc, Christopher R.

Cell ; 170(5): 875-888.e20, 2017 Aug 24.

Artigo em Inglês | MEDLINE | ID: mdl-28757253

14.

EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR.

Kaplan, Mohammed; Narasimhan, Siddarth; de Heus, Cecilia; Mance, Deni; van Doorn, Sander; Houben, Klaartje; Popov-Celeketic, Dusan; Damman, Reinier; Katrukha, Eugene A; Jain, Purvi; Geerts, Willie J C; Heck, Albert J R; Folkers, Gert E; Kapitein, Lukas C; Lemeer, Simone; van Bergen En Henegouwen, Paul M P; Baldus, Marc.

Cell ; 167(5): 1241-1251.e11, 2016 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-27839865

15.

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

Tsai, Jonathan M; Aguirre, Jacob D; Li, Yen-Der; Brown, Jared; Focht, Vivian; Kater, Lukas; Kempf, Georg; Sandoval, Brittany; Schmitt, Stefan; Rutter, Justine C; Galli, Pius; Sandate, Colby R; Cutler, Jevon A; Zou, Charles; Donovan, Katherine A; Lumpkin, Ryan J; Cavadini, Simone; Park, Paul M C; Sievers, Quinlan; Hatton, Charlie; Ener, Elizabeth; Regalado, Brandon D; Sperling, Micah T; Slabicki, Mikolaj; Kim, Jeonghyeon; Zon, Rebecca; Zhang, Zinan; Miller, Peter G; Belizaire, Roger; Sperling, Adam S; Fischer, Eric S; Irizarry, Rafael; Armstrong, Scott A; Thomä, Nicolas H; Ebert, Benjamin L.

Mol Cell ; 83(15): 2753-2767.e10, 2023 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-37478846

16.

Ubiquitous L1 mosaicism in hippocampal neurons.

Upton, Kyle R; Gerhardt, Daniel J; Jesuadian, J Samuel; Richardson, Sandra R; Sánchez-Luque, Francisco J; Bodea, Gabriela O; Ewing, Adam D; Salvador-Palomeque, Carmen; van der Knaap, Marjo S; Brennan, Paul M; Vanderver, Adeline; Faulkner, Geoffrey J.

Cell ; 161(2): 228-39, 2015 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-25860606

17.

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Perry, Rachel J; Camporez, João-Paulo G; Kursawe, Romy; Titchenell, Paul M; Zhang, Dongyan; Perry, Curtis J; Jurczak, Michael J; Abudukadier, Abulizi; Han, Myoung Sook; Zhang, Xian-Man; Ruan, Hai-Bin; Yang, Xiaoyong; Caprio, Sonia; Kaech, Susan M; Sul, Hei Sook; Birnbaum, Morris J; Davis, Roger J; Cline, Gary W; Petersen, Kitt Falk; Shulman, Gerald I.

Cell ; 160(4): 745-758, 2015 Feb 12.

Artigo em Inglês | MEDLINE | ID: mdl-25662011

18.

Transforming a head direction signal into a goal-oriented steering command.

Westeinde, Elena A; Kellogg, Emily; Dawson, Paul M; Lu, Jenny; Hamburg, Lydia; Midler, Benjamin; Druckmann, Shaul; Wilson, Rachel I.

Nature ; 626(8000): 819-826, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38326621

19.

De novo design of high-affinity binders of bioactive helical peptides.

Vázquez Torres, Susana; Leung, Philip J Y; Venkatesh, Preetham; Lutz, Isaac D; Hink, Fabian; Huynh, Huu-Hien; Becker, Jessica; Yeh, Andy Hsien-Wei; Juergens, David; Bennett, Nathaniel R; Hoofnagle, Andrew N; Huang, Eric; MacCoss, Michael J; Expòsit, Marc; Lee, Gyu Rie; Bera, Asim K; Kang, Alex; De La Cruz, Joshmyn; Levine, Paul M; Li, Xinting; Lamb, Mila; Gerben, Stacey R; Murray, Analisa; Heine, Piper; Korkmaz, Elif Nihal; Nivala, Jeff; Stewart, Lance; Watson, Joseph L; Rogers, Joseph M; Baker, David.

Nature ; 626(7998): 435-442, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38109936

20.

Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.

He, Dan; Feng, Huijin; Sundberg, Belen; Yang, Jiaxing; Powers, Justin; Christian, Alec H; Wilkinson, John E; Monnin, Cian; Avizonis, Daina; Thomas, Craig J; Friedman, Richard A; Kluger, Michael D; Hollingsworth, Michael A; Grandgenett, Paul M; Klute, Kelsey A; Toste, F Dean; Chang, Christopher J; Chio, Iok In Christine.

Mol Cell ; 82(16): 3045-3060.e11, 2022 08 18.

Artigo em Inglês | MEDLINE | ID: mdl-35752173

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Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung.

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron.

Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination at oriP and viral episome maintenance.

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.

Autism-related dietary preferences mediate autism-gut microbiome associations.

Zona Pellucida Proteins, Fibrils, and Matrix.

Charting the Complexity of the Marine Microbiome through Single-Cell Genomics.

Autism-related dietary preferences mediate autism-gut microbiome associations.

Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation.

mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates.

CD4⁺ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy.

Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions.

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.

EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR.

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

Ubiquitous L1 mosaicism in hippocampal neurons.

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Transforming a head direction signal into a goal-oriented steering command.

De novo design of high-affinity binders of bioactive helical peptides.

Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.