Detalhe da pesquisa
1.
DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation.
Nucleic Acids Res
; 50(D1): D480-D487, 2022 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34850135
2.
The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains.
J Biol Chem
; 298(5): 101902, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35390347
3.
Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation.
Int J Mol Sci
; 23(23)2022 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36499173
4.
Design, synthesis and structure-activity evaluation of novel 2-pyridone-based inhibitors of α-synuclein aggregation with potentially improved BBB permeability.
Bioorg Chem
; 117: 105472, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34775206
5.
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.
Proc Natl Acad Sci U S A
; 115(41): 10481-10486, 2018 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249646
6.
Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease.
J Enzyme Inhib Med Chem
; 35(1): 1727-1735, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32924648
7.
High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors.
Int J Mol Sci
; 18(3)2017 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28257086
8.
Functional Amyloids: The Biomaterials of Tomorrow?
Adv Mater
; 36(18): e2312823, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38308110
9.
Development of Small Molecules Targeting α-Synuclein Aggregation: A Promising Strategy to Treat Parkinson's Disease.
Pharmaceutics
; 15(3)2023 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36986700
10.
One ring is sufficient to inhibit α-synuclein aggregation.
Neural Regen Res
; 17(3): 508-511, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-34380879
11.
Discovery of Neuroprotective Agents Based on a 5-(4-Pyridinyl)-1,2,4-triazole Scaffold.
ACS Chem Neurosci
; 13(5): 581-586, 2022 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35179861
12.
α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity.
Nat Commun
; 12(1): 3752, 2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34145261
13.
Chemical Chaperones as Novel Drugs for Parkinson's Disease.
Trends Mol Med
; 26(4): 408-421, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32277934
14.
Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm.
Front Bioeng Biotechnol
; 8: 588947, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33178678
15.
ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization.
Front Mol Neurosci
; 12: 306, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31920537
16.
AGGRESCAN3D: Toward the Prediction of the Aggregation Propensities of Protein Structures.
Methods Mol Biol
; 1762: 427-443, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29594784
17.
Small molecules to prevent the neurodegeneration caused by α-synuclein aggregation.
Neural Regen Res
; 15(12): 2260-2261, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32594046