Detalhe da pesquisa
1.
Selections and screenings of DNA-encoded chemical libraries against enzyme and cellular targets.
Bioorg Med Chem Lett
; 39: 127851, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33631371
2.
Palladium-mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected aminomethyltrifluoroborate with DNA-Conjugated aryl bromides for DNA-Encoded chemical library synthesis.
Biochem Biophys Res Commun
; 533(2): 209-214, 2020 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32376009
3.
DNA-Compatible Copper-Catalyzed Oxidative Amidation of Aldehydes with Non-Nucleophilic Arylamines.
Bioconjug Chem
; 31(9): 2092-2097, 2020 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32804494
4.
Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71.
Biochim Biophys Acta
; 1860(6): 1299-307, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26987809
5.
Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice.
Bioorg Med Chem Lett
; 27(10): 2087-2093, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28389149
6.
Design, synthesis, and biological evaluation of anti-EV71 agents.
Bioorg Med Chem Lett
; 26(14): 3346-3350, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27234148
7.
Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6).
Bioorg Med Chem Lett
; 25(17): 3636-43, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26141771
8.
Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4).
Bioorg Med Chem Lett
; 25(11): 2409-15, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25911300
9.
Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).
Bioorg Med Chem Lett
; 25(12): 2473-8, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25978963
10.
Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
Bioorg Med Chem Lett
; 25(9): 1831-5, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25851938
11.
Conformational plasticity of the 2A proteinase from enterovirus 71.
J Virol
; 87(13): 7348-56, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23616646
12.
Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 5): 866-71, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23633597
13.
Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile.
ACS Med Chem Lett
; 12(6): 1038-1049, 2021 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141090
14.
Synthesis of 1,2-Amino Alcohols by Photoredox-Mediated Decarboxylative Coupling of α-Amino Acids and DNA-Conjugated Carbonyls.
Org Lett
; 22(24): 9484-9489, 2020 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33170713
15.
DNA Compatible Intermolecular Wittig Olefination for the Construction of α, ß-Unsaturated Carbonyl Compounds.
Org Lett
; 22(10): 3931-3935, 2020 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32364391
16.
Copper-Mediated DNA-Compatible One-Pot Click Reactions of Alkynes with Aryl Borates and TMS-N3.
Org Lett
; 22(11): 4146-4150, 2020 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32383596
17.
Solution-Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering.
iScience
; 23(6): 101142, 2020 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32446221
18.
A Strategy for the Synthesis of Sulfonamides on DNA.
Org Lett
; 21(24): 9909-9913, 2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31789038
19.
Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876.
ChemMedChem
; 12(17): 1436-1448, 2017 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28741898