Detalhe da pesquisa
1.
First-in-human study of alpibectir (BVL-GSK098), a novel potent anti-TB drug.
J Antimicrob Chemother
; 79(6): 1353-1361, 2024 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38656557
2.
Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity.
Biochem Soc Trans
; 48(3): 787-797, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32453388
3.
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
Toxicol Appl Pharmacol
; 403: 115163, 2020 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32730777
4.
Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury.
Chem Res Toxicol
; 33(12): 2939-2943, 2020 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33169987
5.
A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial.
Nat Med
; 30(3): 896-904, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38365949
6.
Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models.
Toxicol In Vitro
; 72: 105096, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33460737
8.
Safety perspectives on presently considered drugs for the treatment of COVID-19.
Br J Pharmacol
; 177(19): 4353-4374, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32681537
9.
Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells.
Toxicol In Vitro
; 61: 104595, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31288073