1.
Brain Res
; 360(1-2): 374-8, 1985 Dec 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4075178
RESUMO
Electrical stimulation of medial brainstem sites produces potent analgesia in rats that is either opioid- or non-opioid-mediated depending on the specific brain region stimulated. Footshock stress also causes opioid and non-opioid forms of analgesia in rats depending on the exact parameters of footshock administered. We now report that opioid, but not non-opioid, stress analgesia demonstrates cross-tolerance with opioid, but not non-opioid, stimulation-produced analgesia. This finding suggests that opioid forms of stimulation-produced and stress-induced analgesia share a common substrate.