Detalhe da pesquisa
1.
Evaluation of In Vitro Models for Assessment of Human Intestinal Metabolism in Drug Discovery.
Drug Metab Dispos
; 48(11): 1169-1182, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32862146
2.
Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn's Disease: A Phase 2a Study.
Gastroenterology
; 153(1): 77-86.e6, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28390867
3.
Structural and functional characterization of a specific antidote for ticagrelor.
Blood
; 125(22): 3484-90, 2015 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25788700
4.
A randomised, placebo-controlled trial of anti-interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease.
Respir Res
; 18(1): 153, 2017 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28793896
5.
At the bench: the key role of PK-PD modelling in enabling the early discovery of biologic therapies.
Br J Clin Pharmacol
; 77(5): 740-5, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23962236
6.
BiSim Tool: a binding simulation tool to aid and simplify ligand-binding assay design and development.
Bioanalysis
; 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38629337
7.
Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-Cλ interface.
MAbs
; 15(1): 2273449, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37930310
8.
Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.
Sci Rep
; 13(1): 9825, 2023 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37330528
9.
"Hot-spotting" to improve vaccine allocation by harnessing digital contact tracing technology: An application of percolation theory.
PLoS One
; 16(9): e0256889, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34551000
10.
Recombinant sclerostin inhibits bone formation in vitro and in a mouse model of sclerosteosis.
J Orthop Translat
; 29: 134-142, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34249611
11.
Applications of Quantitative Systems Pharmacology in Model-Informed Drug Discovery: Perspective on Impact and Opportunities.
CPT Pharmacometrics Syst Pharmacol
; 8(11): 777-791, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31535440
12.
Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network.
CPT Pharmacometrics Syst Pharmacol
; 8(5): 259-272, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30667172
13.
Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
CPT Pharmacometrics Syst Pharmacol
; 7(3): 135-146, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29349875
14.
Evaluation of molecular markers in low-grade diffuse astrocytomas: loss of p16 and retinoblastoma protein expression is associated with short survival.
Am J Surg Pathol
; 26(4): 472-8, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11914625
15.
Prevalence of lymphoreticular prion protein accumulation in UK tissue samples.
J Pathol
; 203(3): 733-9, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15221931
16.
Accumulation of prion protein in tonsil and appendix: review of tissue samples.
BMJ
; 325(7365): 633-4, 2002 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12242174