Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology.

Settembre, Carmine; Perera, Rushika M.

Nat Rev Mol Cell Biol ; 25(3): 223-245, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38001393

2.

The Lysosome as a Regulatory Hub.

Perera, Rushika M; Zoncu, Roberto.

Annu Rev Cell Dev Biol ; 32: 223-253, 2016 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-27501449

3.

Autophagy in cancer cell remodeling and quality control.

Hernandez, Grace A; Perera, Rushika M.

Mol Cell ; 82(8): 1514-1527, 2022 04 21.

Artigo em Inglês | MEDLINE | ID: mdl-35452618

4.

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.

Yamamoto, Keisuke; Venida, Anthony; Yano, Julian; Biancur, Douglas E; Kakiuchi, Miwako; Gupta, Suprit; Sohn, Albert S W; Mukhopadhyay, Subhadip; Lin, Elaine Y; Parker, Seth J; Banh, Robert S; Paulo, Joao A; Wen, Kwun Wah; Debnath, Jayanta; Kim, Grace E; Mancias, Joseph D; Fearon, Douglas T; Perera, Rushika M; Kimmelman, Alec C.

Nature ; 581(7806): 100-105, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32376951

5.

Autophagy in major human diseases.

Klionsky, Daniel J; Petroni, Giulia; Amaravadi, Ravi K; Baehrecke, Eric H; Ballabio, Andrea; Boya, Patricia; Bravo-San Pedro, José Manuel; Cadwell, Ken; Cecconi, Francesco; Choi, Augustine M K; Choi, Mary E; Chu, Charleen T; Codogno, Patrice; Colombo, Maria Isabel; Cuervo, Ana Maria; Deretic, Vojo; Dikic, Ivan; Elazar, Zvulun; Eskelinen, Eeva-Liisa; Fimia, Gian Maria; Gewirtz, David A; Green, Douglas R; Hansen, Malene; Jäättelä, Marja; Johansen, Terje; Juhász, Gábor; Karantza, Vassiliki; Kraft, Claudine; Kroemer, Guido; Ktistakis, Nicholas T; Kumar, Sharad; Lopez-Otin, Carlos; Macleod, Kay F; Madeo, Frank; Martinez, Jennifer; Meléndez, Alicia; Mizushima, Noboru; Münz, Christian; Penninger, Josef M; Perera, Rushika M; Piacentini, Mauro; Reggiori, Fulvio; Rubinsztein, David C; Ryan, Kevin M; Sadoshima, Junichi; Santambrogio, Laura; Scorrano, Luca; Simon, Hans-Uwe; Simon, Anna Katharina; Simonsen, Anne.

EMBO J ; 40(19): e108863, 2021 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-34459017

6.

A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes.

Zoncu, Roberto; Perera, Rushika M; Balkin, Daniel M; Pirruccello, Michelle; Toomre, Derek; De Camilli, Pietro.

Cell ; 136(6): 1110-21, 2009 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-19303853

7.

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.

Perera, Rushika M; Stoykova, Svetlana; Nicolay, Brandon N; Ross, Kenneth N; Fitamant, Julien; Boukhali, Myriam; Lengrand, Justine; Deshpande, Vikram; Selig, Martin K; Ferrone, Cristina R; Settleman, Jeff; Stephanopoulos, Gregory; Dyson, Nicholas J; Zoncu, Roberto; Ramaswamy, Sridhar; Haas, Wilhelm; Bardeesy, Nabeel.

Nature ; 524(7565): 361-5, 2015 Aug 20.

Artigo em Inglês | MEDLINE | ID: mdl-26168401

8.

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Son, Jaekyoung; Lyssiotis, Costas A; Ying, Haoqiang; Wang, Xiaoxu; Hua, Sujun; Ligorio, Matteo; Perera, Rushika M; Ferrone, Cristina R; Mullarky, Edouard; Shyh-Chang, Ng; Kang, Ya'an; Fleming, Jason B; Bardeesy, Nabeel; Asara, John M; Haigis, Marcia C; DePinho, Ronald A; Cantley, Lewis C; Kimmelman, Alec C.

Nature ; 496(7443): 101-5, 2013 Apr 04.

Artigo em Inglês | MEDLINE | ID: mdl-23535601

9.

Stromal response to Hedgehog signaling restrains pancreatic cancer progression.

Lee, John J; Perera, Rushika M; Wang, Huaijun; Wu, Dai-Chen; Liu, X Shawn; Han, Shiwei; Fitamant, Julien; Jones, Phillip D; Ghanta, Krishna S; Kawano, Sally; Nagle, Julia M; Deshpande, Vikram; Boucher, Yves; Kato, Tomoyo; Chen, James K; Willmann, Jürgen K; Bardeesy, Nabeel; Beachy, Philip A.

Proc Natl Acad Sci U S A ; 111(30): E3091-100, 2014 Jul 29.

Artigo em Inglês | MEDLINE | ID: mdl-25024225

10.

Functional outcomes and quality of life after proximal gastrectomy with esophagogastrostomy using a narrow gastric conduit.

Ronellenfitsch, Ulrich; Najmeh, Sara; Andalib, Amin; Perera, Rushika M; Rousseau, Mathieu C; Mulder, David S; Ferri, Lorenzo E.

Ann Surg Oncol ; 22(3): 772-9, 2015 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-25212836

11.

Emerging roles of the MiT/TFE factors in cancer.

Zoncu, Roberto; Perera, Rushika M.

Trends Cancer ; 9(10): 817-827, 2023 10.

Artigo em Inglês | MEDLINE | ID: mdl-37400313

12.

Functional characterization of Alzheimer's disease genetic variants in microglia.

Yang, Xiaoyu; Wen, Jia; Yang, Han; Jones, Ian R; Zhu, Xiaodong; Liu, Weifang; Li, Bingkun; Clelland, Claire D; Luo, Wenjie; Wong, Man Ying; Ren, Xingjie; Cui, Xiekui; Song, Michael; Liu, Hongjiang; Chen, Cady; Eng, Nicolas; Ravichandran, Mirunalini; Sun, Yang; Lee, David; Van Buren, Eric; Jiang, Min-Zhi; Chan, Candace S Y; Ye, Chun Jimmie; Perera, Rushika M; Gan, Li; Li, Yun; Shen, Yin.

Nat Genet ; 55(10): 1735-1744, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37735198

13.

Cancer: when antioxidants are bad.

Perera, Rushika M; Bardeesy, Nabeel.

Nature ; 475(7354): 43-4, 2011 Jul 06.

Artigo em Inglês | MEDLINE | ID: mdl-21734699

14.

Built to last: lysosome remodeling and repair in health and disease.

Zoncu, Roberto; Perera, Rushika M.

Trends Cell Biol ; 32(7): 597-610, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35123838

15.

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.

Shin, Hijai R; Citron, Y Rose; Wang, Lei; Tribouillard, Laura; Goul, Claire S; Stipp, Robin; Sugasawa, Yusuke; Jain, Aakriti; Samson, Nolwenn; Lim, Chun-Yan; Davis, Oliver B; Castaneda-Carpio, David; Qian, Mingxing; Nomura, Daniel K; Perera, Rushika M; Park, Eunyong; Covey, Douglas F; Laplante, Mathieu; Evers, Alex S; Zoncu, Roberto.

Science ; 377(6612): 1290-1298, 2022 09 16.

Artigo em Inglês | MEDLINE | ID: mdl-36007018

16.

Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer.

Ravichandran, Mirunalini; Hu, Jingjie; Cai, Charles; Ward, Nathan P; Venida, Anthony; Foakes, Callum; Kuljanin, Miljan; Yang, Annan; Hennessey, Connor J; Yang, Yang; Desousa, Brandon R; Rademaker, Gilles; Staes, Annelot A L; Cakir, Zeynep; Jain, Isha H; Aguirre, Andrew J; Mancias, Joseph D; Shen, Yin; DeNicola, Gina M; Perera, Rushika M.

Cancer Discov ; 12(9): 2198-2219, 2022 09 02.

Artigo em Inglês | MEDLINE | ID: mdl-35771494

17.

Zooming in on the cell biology of disease.

Perera, Rushika M.

Mol Biol Cell ; 32(22): ae4, 2021 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-34747628

18.

Oncogene-regulated release of extracellular vesicles.

Kilinc, Seda; Paisner, Rebekka; Camarda, Roman; Gupta, Suprit; Momcilovic, Olga; Kohnz, Rebecca A; Avsaroglu, Baris; L'Etoile, Noelle D; Perera, Rushika M; Nomura, Daniel K; Goga, Andrei.

Dev Cell ; 56(13): 1989-2006.e6, 2021 07 12.

Artigo em Inglês | MEDLINE | ID: mdl-34118203

19.

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth.

Gupta, Suprit; Yano, Julian; Mercier, Vincent; Htwe, Htet Htwe; Shin, Hijai R; Rademaker, Gilles; Cakir, Zeynep; Ituarte, Thomas; Wen, Kwun W; Kim, Grace E; Zoncu, Roberto; Roux, Aurélien; Dawson, David W; Perera, Rushika M.

Nat Cell Biol ; 23(3): 232-242, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33686253

20.

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.

Davis, Oliver B; Shin, Hijai R; Lim, Chun-Yan; Wu, Emma Y; Kukurugya, Matthew; Maher, Claire F; Perera, Rushika M; Ordonez, M Paulina; Zoncu, Roberto.

Dev Cell ; 56(3): 260-276.e7, 2021 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-33308480

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