Role of the Autonomic Nervous System and Vascular Endothelial Factors in the Development of Primary Arterial Hypotension in Paediatric Patients.

BACKGROUND: There is a dearth and inconsistency of data on the role of the autonomic nervous system (ANS) in the development of arterial hypotension. Also, little is known about the involvement of endothelial factors in the development of this disease. The aim of the study was to investigate the role of the ANS and endothelial factors or vasoregulators in the development of primary arterial hypotension (PAH) in children. METHODS: The cardiointervalography and clino-orthostatic test results of 113 children with PAH were compared with 88 healthy children of comparable age (7-11 years). Serum endothelial factors (nitric oxide and endothelins) of all children were measured. RESULTS: The findings revealed that children with PAH had higher activity of the sympathetic (p<0.001) and parasympathetic (p<0.001) divisions of the ANS at the initial (resting) position of clino-orthostatic test. The activity of these divisions of the autonomic nervous system correlated with the activity of a cardiac pacemaker. The change of position from horizontal into vertical was accompanied by a rise only in sympathetic activity (p<0.001). However, there was a decline in the sympathetic nervous system (p<0.001) compared to the indices of the initial (resting) position registered in the tenth minute of the vertical position. The parasympathetic division of the ANS based on heart rate variability showed high activity in all positions of the clino-orthostatic test in the patients with PAH compared with healthy children. The activity of the parasympathetic nervous system was associated with increased synthesis of endothelial factors (nitric oxide and endothelins) in blood. CONCLUSIONS: The inadequate response of the autonomic nervous system to the clino-orthostatic test in children with PAH is associated with disorders of both divisions of the autonomic nervous system as well as vascular endothelial factors.

Do reactive oxygen species damage or protect the heart in ischemia and reperfusion? Analysis on experimental and clinical data.

The role of reactive oxygen species (ROS) in ischemic and reperfusion (I/R) injury of the heart has been discussed for more than 40 years. It has been demonstrated that reperfusion triggers a multiple increase in free radical generation in the isolated heart. Antioxidants were found to have the ability to mitigate I/R injury of the heart. However, it is unclear whether their cardioprotective effect truly depends on the decrease of ROS levels in myocardial tissues. Since high doses and high concentrations of antioxidants were experimentally used, it is highly likely that the cardioprotective effect of antioxidants depends on their interaction not only with free radicals but also with other molecules. It has been demonstrated that the antioxidant N-2-mercaptopropionyl glycine or NDPH oxidase knockout abolished the cardioprotective effect of ischemic preconditioning. Consequently, there is evidence that ROS protect the heart against the I/R injury.

Prevalence of alcohol-related problems among the Slavs and Arabs in Belarus: a university survey.

BACKGROUND: Alcohol abuse is a major problem among students in Belarus. Alcohol-related problems might vary among students of different cultural backgrounds. OBJECTIVES: To examine the different patterns in alcohol use and related problems among students of different cultural groups--the Slavs and Arabs, in major Belarusian universities. METHODS: 1465 university students (1345 Slavs and 120 Arabs) from three major universities in Minsk, Belarus, were administered the Alcohol Use Disorders Identification Test, the Cut, Annoyed, Guilty and Eye questionnaire, and the Michigan Alcohol Screening Test, including other alcohol-related questions. RESULTS: Overall, 91.08% (n = 1225) Slavs and 60.83% (n = 73) Arabs were alcohol users. A total of 16.28% (n = 219) Slavs and 32.50% (n = 39) Arabs were identified as problem drinkers. Different patterns of alcohol use and related problems were characterized for the Slavs and Arabs. The level of alcohol-related problems was higher among the Arabs, compared to the Slavs. CONCLUSION: Significant differences in the pattern of alcohol use and related problems exist among the students of various cultural groups--the Slavs and Arabs in Minsk, Belarus. SCIENTIFIC SIGNIFICANCE: This is the first empirical study to investigate the prevalence of alcohol use and related problems among the Arab and Slav students in Belarus.

The effect of foot reflexotherapy on the dynamics of cortical oscillatory waves in healthy humans: An EEG study.

BACKGROUND: Foot reflexotherapy is a noninvasive complementary therapy that has gained considerable application in several fields of human endeavor. The therapy is used to relieve the symptoms of several ailments. For instance, foot reflexotherapy when applied to the cortical areas of the left or right foot relieves pain and stress. However, the electrophysiological mechanisms of the effect of foot reflexotherapy on cortical activity are not completely understood. While it has been shown that foot reflexotherapy exert positive effects on brain functions, little is known about the effects of this therapy on cortical activities as recorded with electroencephalogram (EEG) in healthy humans. Cortical activity is widely investigated with EEG, a noninvasive recording that is used to study brain activity in different functional states and conditions. AIM: The aim of this study was to investigate the effect of foot reflexotherapy on EEG rhythms in healthy humans. MATERIAL AND METHODS: EEG recording before and after reflexological therapy was carried out in seven healthy right-handed males who volunteered for the study. RESULTS: Analysis of EEG data revealed activation offrontal cortex that resulted to significant increase in beta and gamma spectral powers after foot reflexotherapy (p ˂ 0.05). CONCLUSION: Foot reflexotherapy is associated with increase in spectral powers in beta and gamma frequency bands. Therefore cortical beta and gamma waves of the EEG could be used as measures of functional activation of the brain, related to foot reflexotherapy.

Are there different mechanisms of synchronization in the course of spike-wave discharges (SWDs) burst development in WAG/Rij rats?

In WAG/Rij rats the pair linear correlation r was calculated for bipolar recordings in fronto-temporal, fronto-occipital and occipito-temporal zones of both hemispheres as well as in paleocerebellar cortex (culmen). It was shown that development of SWD bursts resulted in interhemispheric decreases of correlation between the right occipito-temporal cortical region on one side, and left fronto-temporal on the contralateral side. Towards the end of SWD, we found an increased interhemispheric correlation between left fronto-temporal and right fronto-occipital cortical zones, as well as, between both fronto-temporal zones. Paleocerebellum correlates at a weak to moderate level during different periods of SWD burst generation.

Sweet taste receptor signaling network: possible implication for cognitive functioning.

Sweet taste receptors are transmembrane protein network specialized in the transmission of information from special "sweet" molecules into the intracellular domain. These receptors can sense the taste of a range of molecules and transmit the information downstream to several acceptors, modulate cell specific functions and metabolism, and mediate cell-to-cell coupling through paracrine mechanism. Recent reports indicate that sweet taste receptors are widely distributed in the body and serves specific function relative to their localization. Due to their pleiotropic signaling properties and multisubstrate ligand affinity, sweet taste receptors are able to cooperatively bind multiple substances and mediate signaling by other receptors. Based on increasing evidence about the role of these receptors in the initiation and control of absorption and metabolism, and the pivotal role of metabolic (glucose) regulation in the central nervous system functioning, we propose a possible implication of sweet taste receptor signaling in modulating cognitive functioning.

Cognitive functions and neuropsychological status of medical students with different attitudes to alcohol use: a study conducted at the Belarusian State Medical University, Minsk, Belarus.

This article presents findings on the effects of alcohol use on cognitive performance, functional (well-being, activity, mood) and neuropsychological status and anxiety levels of medical students. A total of 265 medical students (107 males and 158 females) from the Belarusian State Medical University, Minsk (Belarus) were administered questionnaire, containing the AUDIT, CAGE, MAST, and PAS, and other alcohol related questions. Academic Performance questionnaire was administered together with other tests. For analysis of cognitive functions, a "correction probe" test was used. The number of students who reported consumption of alcohol was 74 males and 142 females. Medical students who reported alcohol consumption had lower cognitive performance and academic success, poor self-assessment of their functional and neuropsychological states, compared to the non-alcohol users. The results of this study suggest an inverse dose-dependent relationship between alcohol consumption, and cognitive functions, academic performance and neuropsychological status of medical students.