Detalhe da pesquisa
1.
Discovery of harmiprims, harmine-primaquine hybrids, as potent and selective anticancer and antimalarial compounds.
Bioorg Med Chem
; 105: 117734, 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38677112
2.
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application.
Angew Chem Int Ed Engl
; 63(19): e202319765, 2024 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38502093
3.
Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action.
Molecules
; 26(8)2021 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33921170
4.
Essential and nonessential metal effects on extracellular Leishmania amazonensis in vitro.
Exp Parasitol
; 209: 107826, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31881207
5.
Novel Harmicines with Improved Potency against Plasmodium.
Molecules
; 25(19)2020 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32977642
6.
The problem of antimalarial resistance and its implications for drug discovery.
Expert Opin Drug Discov
; 19(2): 209-224, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38108082
7.
Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR).
ACS Infect Dis
; 10(5): 1739-1752, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38647213
8.
Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.
EBioMedicine
; 97: 104814, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37839134
9.
Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents.
Eur J Med Chem
; 238: 114408, 2022 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35551033
10.
Further investigation of harmicines as novel antiplasmodial agents: Synthesis, structure-activity relationship and insight into the mechanism of action.
Eur J Med Chem
; 224: 113687, 2021 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34274829
11.
3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum.
J Med Chem
; 64(6): 3035-3047, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33666415
12.
Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits.
Eur J Med Chem
; 187: 111927, 2020 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31812035
13.
Intracellular development of Trypanosoma cruzi in the presence of metals.
J Parasit Dis
; 42(3): 372-381, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-30166784